Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

1989 • 1,030 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA topoisomerase II is required at the time of mitosis in yeast

1985 • 747 citations

Transcription generates positively and negatively supercoiled domains in the template

1988 • 742 citations

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

1987 • 691 citations

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

1984 • 685 citations

Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster

1986 • 587 citations

Cleavage of DNA by mammalian DNA topoisomerase II.

1983 • 539 citations

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

1985 • 472 citations

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA

1987 • 426 citations

Disassembly of the nucleus in mitotic extracts: Membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes

1987 • 349 citations

Recent studies of DNA topoisomerases

1987 • 323 citations

Roles of DNA topoisomerases in simian virus 40 DNA replication in vitro.

1987 • 293 citations

Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster.

1983 • 284 citations

Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants

1988 • 277 citations

Identification of cellular proteins required for simian virus 40 DNA replication

1989 • 238 citations

The metaphase scaffold is helically folded: Sister chromatids have predominantly opposite helical handedness

1988 • 232 citations

Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks.

1988 • 214 citations

Determination of the extent of DNA bending by an adenine-thymine tract

1990 • 213 citations

Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae

1989 • 174 citations

Altered DNA topoisomerase II activity in Chinese hamster cells resistant to topoisomerase II inhibitors.

1986 • 173 citations

Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity

1990 • 153 citations

Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

1986 • 145 citations

Interaction of DNA with nuclear scaffolds in vitro

1988 • 143 citations

In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin

1985 • 138 citations

Scaffold attachment of DNA loops in metaphase chromosomes

1988 • 137 citations

Topoisomerase Inhibitors Can Selectively Interfere with Different Stages of Simian Virus 40 DNA Replication

1986 • 135 citations

Detection, sequence patterns and function of unusual DNA structures

1986 • 119 citations

Nuclease protection by Drosophila DNA topoisomerase II

1989 • 112 citations

In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin.

1986 • 96 citations

The topoisomerase II inhibitor VM-26 induces marked changes in histone H1 kinase activity, histones H1 and H3 phosphorylation, and chromosome condensation in G2 phase and mitotic BHK cells.

1990 • 90 citations

The termination region for SV40 DNA replication directs the mode of separation for the two sibling molecules

1985 • 84 citations

Topoisomerase inhibitors can selectively interfere with different stages of simian virus 40 DNA replication.

1986 • 80 citations

Topoisomerase II cleavage in chromatin

1986 • 79 citations

Drosophila topoisomerase II-DNA interactions are affected by DNA structure

1991 • 61 citations

Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase in reconstituted Simian virus 40 chromatin

1990 • 54 citations

Role of DNA intercalation in the inhibition of purified mouse leukemia (L1210) DNA topoisomerase II by 9-aminoacridines

1987 • 50 citations

Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

1990 • 47 citations

Mammalian Topoisomerase II Activity Is Modulated by the DNA Minor Groove Binder Distamycin in Simian Virus 40 DNA

1989 • 45 citations

In vivo stimulation by antitumor drugs of the topoisomerase II induced cleavage sites in c-myc protooncogene

1986 • 43 citations

DNA topoisomerase II cleaves at specific sites in the 5′ flanking region of c-fos proto-oncogenes in vitro.

1986 • 42 citations

Teniposide, a topoisomerase II inhibitor, prevents chromosome condensation and separation but not decondensation in fertilized surf clam (Spisula solidissima) oocytes

1990 • 38 citations

Effect of phorbol ester treatment on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells.

1988 • 35 citations

Patterns of strongly protein-associated simian virus 40 DNA replication intermediates resulting from exposures to specific topoisomerase poisons

1990 • 23 citations

Topoisomerase II Inhibition by Antitumor Intercalators and Demethylepipodophyllotoxins

2019 • 7 citations