Nucleosome positioning as a critical determinant for the DNA cleavage sites of mammalian DNA topoisomerase in reconstituted Simian virus 40 chromatin

DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

1989 • 1,799 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

1984 • 1,477 citations

Complete nucleotide sequence of SV40 DNA

1978 • 1,050 citations

Structure of the nucleosome core particle at 7 Å resolution

1984 • 1,028 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

Structure of nucleosome core particles of chromatin

1977 • 746 citations

DNA bending and its relation to nucleosome positioning

1985 • 702 citations

Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster

1986 • 587 citations

Metaphase chromosome structure

1986 • 538 citations

Localization of topoisomerase II in mitotic chromosomes.

1985 • 501 citations

In situ localization of DNA topoisomerase II, a major polypeptide component of the Drosophila nuclear matrix fraction.

1985 • 472 citations

Absence of nucleosomes in a fraction of SV40 chromatin between the origin of replication and the region coding for the late leader RNA

1980 • 372 citations

Recent studies of DNA topoisomerases

1987 • 323 citations

Interaction of specific nuclear factors with the nuclease-hypersensitive region of the chicken adult β-globin gene: Nature of the binding domain

1985 • 255 citations

A nucleosome-free region in SV40 minichromosomes

1980 • 254 citations

A consensus sequence for cleavage by vertebrate DNA topoisomerase II

1988 • 253 citations

Drosophilatopoisomerase II double-strand DNA cleavage: analysis of DNA sequence homology at the cleavage site

1985 • 239 citations

Assembly of transcriptionally active 5S RNA gene chromatin in vitro

1982 • 195 citations

Core Particle, Fiber, and Transcriptionally Active Chromatin Structure

1986 • 159 citations

Nucleosome assembly

1980 • 154 citations

Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity

1990 • 153 citations

Isolation of intercalator-dependent protein-linked DNA strand cleavage activity from cell nuclei and identification as topoisomerase II

1986 • 145 citations

In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin

1985 • 138 citations

Identification of DNA topoisomerase II as an intracellular target of antitumor epipodophyllotoxins in simian virus 40-infected monkey cells.

1985 • 136 citations

Developments of Cancer Chemotherapy

1980 • 113 citations

In vivo localization of DNA topoisomerase II cleavage sites on Drosophila heat shock chromatin.

1986 • 96 citations

Topoisomerase II cleavage in chromatin

1986 • 79 citations

Hyperacetylation of core histones does not cause unfolding of nucleosomes. Neutron scatter data accords with disc shape of the nucleosome.

1986 • 75 citations

Topological complexes between DNA and topoisomerase II and the effects of polyamines

1989 • 56 citations

Thermal Denaturation Studies of Acetylated Nucleosomes and Oligonucleosmes

1982 • 55 citations

Identification within the simian virus 40 genome of a chromosomal loop attachment site that contains topoisomerase II cleavage sites

1990 • 47 citations

Effects of DNA supercoiling on the topological properties of nucleosomes.

1987 • 46 citations

Mammalian Topoisomerase II Activity Is Modulated by the DNA Minor Groove Binder Distamycin in Simian Virus 40 DNA

1989 • 45 citations

In vivo stimulation by antitumor drugs of the topoisomerase II induced cleavage sites in c-myc protooncogene

1986 • 43 citations

Formation of a nucleosome-free region in SV40 minichromosomes is dependent upon a restricted segment of DNA

1982 • 36 citations

Competition for formation of nucleosomes on fragmented SV40 DNA: a hyperstable nucleosome forms on the termination region

1987 • 30 citations

In Vivo Localization of DNA Topoisomerase II Cleavage Sites on Drosophila Heat Shock Chromatin

1986 • 26 citations

Unique positioning of reconstituted nucleosomes occurs in one region of simian virus 40 DNA.

1987 • 21 citations

High resolution psoralen mapping reveals an altered DNA helical structure in the SV40 regulatory region

1988 • 18 citations

Characterization of the topoisomerase II-induced cleavage sites in the c-myc proto-oncogene

1986 • 16 citations

Pattern of recognition of DNA by mammalian DNA topoisomerase II

1988 • 9 citations