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1990 • 1,049 citations

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Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

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1992 • 691 citations

Induction of proto-oncogene JUN/AP-1 by serum and TPA

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1986 • 680 citations

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T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

1982 • 617 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

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Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

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1992 • 542 citations

An Unidentified Virus which causes the Rapid Production of Tumours in Mice

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

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The phorbol ester receptor: a phospholipid-regulated protein kinase

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1986 • 478 citations

Expression of epidermal growth factor receptors in human brain tumors.

1984 • 478 citations

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Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

1994 • 450 citations

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1991 • 446 citations

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A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

1995 • 393 citations

Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

1993 • 393 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

Amplification and/or overexpression of platelet-derived growth factor receptors and epidermal growth factor receptor in human glial tumors.

1992 • 380 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research

1995 • 374 citations

Protein farnesyltransferase and geranylgeranyltransferase share a common α subunit

1991 • 371 citations

Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes

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Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

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1988 • 354 citations

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

1983 • 352 citations

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1994 • 342 citations

Differential regulation of rasGAP and neurofibromatosis gene product activities

1991 • 338 citations

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1994 • 333 citations

Proliferation of human malignant astrocytomas is dependent on Ras activation

1997 • 331 citations

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1992 • 323 citations

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1992 • 323 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class.

1988 • 314 citations

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1994 • 314 citations

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1991 • 312 citations

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1985 • 310 citations

Dynamic fatty acylation of p21N-ras.

1987 • 309 citations

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1993 • 306 citations

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1995 • 298 citations

EGF receptor in neoplasia and metastasis

1993 • 297 citations

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

1995 • 294 citations

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

1994 • 287 citations

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1994 • 281 citations

Efficient reversion of simian sarcoma virus-transformation and inhibition of growth factor-induced mitogenesis by suramin.

1986 • 270 citations

Chromosomal Localization of the Human Homolog (c- sis ) of the Simian Sarcoma Virus onc Gene

1982 • 262 citations

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

1993 • 257 citations

Critical role of Rho in cell transformation by oncogenic Ras.

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1994 • 255 citations

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1996 • 254 citations

Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene

1995 • 253 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas.

1993 • 246 citations

Nuclear Localization and Regulation of erk-and rsk-Encoded Protein Kinases

1992 • 246 citations

PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine

1995 • 245 citations

A Role for the Ral Guanine Nucleotide Dissociation Stimulator in Mediating Ras-induced Transformation

1996 • 245 citations

Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956.

1995 • 241 citations

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1995 • 237 citations

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1996 • 234 citations

Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta.

1994 • 221 citations

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.

1991 • 221 citations

Evidence that Farnesyltransferase Inhibitors Suppress Ras Transformation by Interfering with Rho Activity

1995 • 220 citations

Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors.

1988 • 218 citations

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.

1988 • 215 citations

Studies on a new epidermal growth factor-receptor kinase inhibitor, erbstatin, produced by MH435-hF3.

1986 • 214 citations

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1992 • 213 citations

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1994 • 194 citations

A tiger behind many doors: multiple genetic pathways to malignant glioma

1995 • 187 citations

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1994 • 182 citations

SOS Phosphorylation and Disassociation of the Grb2-SOS Complex by the ERK and JNK Signaling Pathways

1996 • 180 citations

Comparison of Biological Properties and Transforming Potential of Human PDGF-A and PDGF-B Chains

1988 • 178 citations

Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

1995 • 176 citations

Enhanced Tumorigenic Behavior of Glioblastoma Cells Expressing a Truncated Epidermal Growth Factor Receptor Is Mediated through the Ras-Shc-Grb2 Pathway

1996 • 175 citations

Identification of NF1 mutations in both alleles of a dermal neurofibroma

1996 • 172 citations

Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor

1984 • 170 citations

The 3Rs of life: Ras, Raf and growth regulation

1994 • 165 citations

Regulation of Raf-1 kinase activity by the 14-3-3 family of proteins.

1995 • 165 citations

Hierarchy of Binding Sites for Grb2 and Shc on the Epidermal Growth Factor Receptor

1994 • 159 citations

Loss of NF1 alleles in phaeochromocytomas from patients with type 1 neurofibromatosis

1992 • 157 citations

Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells.

1993 • 155 citations

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.

1996 • 152 citations

Clinical and Radiographic Response in a Minority of Patients with Recurrent Malignant Gliomas Treated with High-Dose Tamoxifen

1993 • 152 citations

Endocytosis and Lysosomal Targeting of Epidermal Growth Factor Receptors Are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domain

1995 • 151 citations

Gene amplification in human gliomas

1995 • 150 citations

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1992 • 148 citations

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1996 • 148 citations

Ras-GTP levels are elevated in human NF1 peripheral nerve tumors.

1996 • 144 citations

Identification of the SH3 Domain of GAP as an Essential Sequence for Ras-GAP-Mediated Signaling

1993 • 137 citations

Enhanced protein kinase C activity correlates with the growth rate of malignant gliomas in vitro

1991 • 133 citations

Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.

1995 • 133 citations

Complexities of the Protein Kinase C Pathway

1991 • 131 citations

Inhibition of cell growth by lovastatin is independent of ras function.

1991 • 130 citations

Regulatory mechanisms for ras proteins

1992 • 129 citations

Protein Kinase C Activity Correlates with the Growth Rate of Malignant Gliomas

1992 • 125 citations

Does Mitogen-Activated-Protein Kinase have a Role in Insulin Action?. The Cases for and Against

1995 • 125 citations

Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro.

1990 • 121 citations

Mechanisms of Glioma Invasion: Role of Matrix-Metalloproteinases

1997 • 120 citations

Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cyclic AMP-mediated signal transduction.

1991 • 113 citations

A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions.

1994 • 113 citations

Farnesyltransferase inhibitors block the neurofibromatosis type I (NF1) malignant phenotype.

1995 • 112 citations

Mapping of the human gene for epidermal growth factor receptor (EGFR) on the p13→q22 region of chromosome 7

1983 • 112 citations

Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors.

1996 • 112 citations

cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene

1991 • 108 citations

Does Mitogen‐Activated‐Protein Kinase have a Role in Insulin Action?

1995 • 107 citations

Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts.

1995 • 104 citations

4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.

1994 • 101 citations

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1996 • 101 citations

Ras signaling and NF1

1995 • 100 citations

Protein Kinase C Inhibitors Suppress Cell Growth in Established and Low-Passage Glioma Cell Lines. A Comparison between Staurosporine and Tamoxifen

1993 • 98 citations

The Treatment of Intracranial Malignant Gliomas Using Orally Administered Tamoxifen Therapy

1992 • 94 citations

Characterization and differential distribution of the three major human protein kinase C isozymes (PKC alpha, PKC beta, and PKC gamma) of the central nervous system in normal and Alzheimer's disease brains.

1991 • 85 citations

MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.

1995 • 85 citations

Intracellular expression of a single-chain antibody directed to the EGFR leads to growth inhibition of tumor cells.

1996 • 85 citations

Activation of the epidermal growth factor receptor tyrosine protein kinase in the absence of receptor oligomerization.

1988 • 84 citations

A negative feedback loop attenuates EGF-induced morphological changes.

1991 • 82 citations

Structural Differences in the Minimal Catalytic Domains of the GTPase-activating Proteins p120GAP and Neurofibromin

1996 • 76 citations

Loss of neurofibromin in adrenal gland tumors from patients with neurofibromatosis type I

1994 • 76 citations

Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells

1982 • 73 citations

Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct.

1992 • 72 citations

Kinetics of inhibition by tyrphostins of the tyrosine kinase activity of the epidermal growth factor receptor and analysis by a new computer program.

1994 • 70 citations

Expression pattern of alpha-protein kinase C in human astrocytomas indicates a role in malignant progression.

1992 • 70 citations

Expression of an altered epidermal growth factor receptor by human glioblastoma cells.

1988 • 68 citations

Expression of growth factor receptors in human brain tumours

1991 • 68 citations

Immunocytochemical localization of the alpha subspecies of protein kinase C in rat brain.

1990 • 67 citations

Pathways of Ras Function: Connections to the Actin Cytoskeleton

1993 • 64 citations

Dominant-negative mutants of a platelet-derived growth factor gene.

1990 • 63 citations

Antisense Expression of Protein Kinase Cα Inhibits the Growth and Tumorigenicity of Human Glioblastoma Cells

1994 • 61 citations

Molecular Localization of the Transforming and Secretory Properties of PDGF A and PDGF B

1990 • 60 citations

Response of malignant glioma cell lines to activation and inhibition of protein kinase C-mediated pathways

1990 • 59 citations

Protein Kinase C‐Activating Tumor Promoters Enhance the Differentiation of Astrocytes in Aggregating Fetal Brain Cell Cultures

1986 • 58 citations

Antisense epidermal growth factor receptor transfection impairs the proliferative ability of human rhabdomyosarcoma cells.

1996 • 57 citations

Reversal of transformed phenotypes by herbimycin A in src oncogene expressed rat fibroblasts.

1988 • 56 citations

Identification of the sites of interaction between c-Raf-1 and Ras-GTP.

1995 • 55 citations

The identification of four protein kinase C isoforms in human glioblastoma cell lines: PKC alpha, gamma, epsilon, and zeta

1994 • 55 citations

Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins

1992 • 54 citations

Altered subcellular location of an activated and tumour-associated epidermal growth factor receptor.

1995 • 53 citations

Amplification of the Structurally and Functionally Altered Epidermal Growth Factor Receptor Gene (c-erbB) in Human Brain Tumors

1988 • 53 citations

Role of protein kinase C in glial cell proliferation

1989 • 51 citations

Reconstitution of the Raf-1-MEK-ERK Signal Transduction Pathway In Vitro

1993 • 51 citations

Two types of RAS mutants that dominantly interfere with activators of RAS.

1994 • 49 citations

Expression of neu/c-erbB-2 in human brain tumors

1994 • 49 citations

Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: oligomerization of kinase domains.

1996 • 47 citations

Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors.

1996 • 47 citations

CaLB: a 43 amino acid calcium-dependent membrane/phospholipid binding domain in p120 Ras GTPase-activating protein.

1995 • 46 citations

Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated

1993 • 46 citations

Constitutive phosphorylation of the epidermal growth factor receptor blocks mitogenic signal transduction.

1991 • 40 citations

Accelerated degradation of 160 kDa epidermal growth factor (EGF) receptor precursor by the tyrosine kinase inhibitor herbimycin A in the endoplasmic reticulum of A431 human epidermoid carcinoma cells

1994 • 39 citations

Dominant-Negative Mutants of Platelet-Derived Growth Factor Revert the Transformed Phenotype of Human Astrocytoma Cells

1993 • 39 citations

p120 Ras GTPase-activating Protein Interacts with Ras-GTP through Specific Conserved Residues

1996 • 37 citations

Acute presentation of a neurogenic sarcoma in a patient with neurofibromatosis type 1: a pathological and molecular explanation

1996 • 37 citations

Unfarnesylated transforming Ras mutant inhibits the Ras‐signaling pathway by forming a stable Ras·Raf complex in the cytosol

1996 • 35 citations

Inhibition of tyrosine kinase and epidermal growth factor receptor internalization by lavendustin A methyl ester in cultured A431 cells.

1990 • 34 citations

Protein kinase C isoforms in human glioblastoma cells

1992 • 34 citations

Platelet-Derived Growth Factor: A General Review with Emphasis on Astrocytomas

1991 • 23 citations

Expression of c-sis and Platelet-Derived Growth Factor in in Vitro-Transformed Glioma Cells from Rat Brain Tissue Transplacentally Treated with Ethylnitrosourea

1986 • 23 citations

A Novel Mammalian Ras GTPase-Activating Protein Which Has Phospholipid-Binding and Btk Homology Regions

1994 • 21 citations

Effect of tyrphostin on cell growth and tyrosine kinase activity of epidermal growth factor receptor in human gliomas

1994 • 20 citations

In vitro characterization of a novel series of platelet-derived growth factor receptor tyrosine kinase inhibitors

1996 • 19 citations

Regulation of pp90^rsk Phosphorylation and S6 Phosphotransferase Activity in Swiss 3T3 Cells by Growth Factor-, Phorbol Ester-, and Cyclic AMP-Mediated Signal Transduction

1991 • 17 citations

Reduced Expression of Neurofibromin in the Soft Tissue Tumours Obtained from Patients with Neurofibromatosis Type 1

1995 • 16 citations

Two Types of RAS Mutants That Dominantly Interfere with Activators of RAS

1994 • 13 citations

Cell density—dependent regulation of PLCγ1 tyrosine phosphorylation and catalytic activity in an intestinal cell line (IEC‐6)

1995 • 12 citations

Protein-tyrosine kinases, oncogenes, and cancer.

1993 • 12 citations

Lovastatin Selectively Inhibits ras Activation of the 12-O-Tetradecanoylphorbol-13-Acetate Response Element in Mammalian Cells

1991 • 10 citations

Epidermal growth factor increases protein and messenger RNA expression levels of Ras GTPase activating protein.

1994 • 4 citations