The 3Rs of life: Ras, Raf and growth regulation

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

1993 • 876 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 • 658 citations

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

1992 • 603 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

Raf functions downstream of Rasl in the Sevenless signal transduction pathway

1992 • 323 citations

C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation

1993 • 276 citations

MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.

1992 • 231 citations

byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype.

1991 • 208 citations

Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

1993 • 128 citations

Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase

1993 • 105 citations

Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.

1993 • 100 citations

The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase.

1993 • 75 citations

Release from G1 growth arrest by transforming growth factor beta 1 requires cellular ras activity.

1993 • 69 citations

Signal Transduction Pathway Initiated by Activation of the sevenless Tyrosine Kinase Receptor

1992 • 14 citations

Cell fates in C. elegans: In medias ras

1990 • 9 citations