4-(Phenylamino)pyrrolopyrimidines: Potent and Selective, ATP Site Directed Inhibitors of the EGF-Receptor Protein Tyrosine Kinase

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Growth Factors and Cancer

1991 • 2,044 citations

Tyrosine Kinase Inhibition: An Approach to Drug Development

1995 • 1,655 citations

Induction of Ectopic Eyes by Targeted Expression of the eyeless Gene in Drosophila

1995 • 1,563 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Fc Receptors Initiate the Arthus Reaction: Redefining the Inflammatory Cascade

1994 • 329 citations

RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class.

1995 • 270 citations

Tyrosine kinase inhibitors. 5. Synthesis and structure-activity relationships for 4-[(phenylmethyl)amino]- and 4-(phenylamino)quinazolines as potent adenosine 5'-triphosphate binding site inhibitors of the tyrosine kinase domain of the epidermal growth factor receptor.

1995 • 259 citations

Isolation of a Novel Tyrosine Kinase Inhibitor, Lavendustin A, from Streptomyces griseolavendus

1989 • 249 citations

Tyrosine kinase inhibitors. 7. 7-amino-4-(phenylamino)- and 7-amino-4-[(phenylmethyl)amino]pyrido[4,3-d]pyrimidines: a new class of inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor

1995 • 138 citations

Purification of Growth Hormone-Specific Transcription Factor GHF-1 Containing Homeobox

1989 • 121 citations

4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity.

1994 • 101 citations

Modelling study of protein kinase inhibitors: Binding mode of staurosporine and origin of the selectivity of CGP 52411

1995 • 95 citations

Dianilinophthalimides: Potent and Selective, ATP-Competitive Inhibitors of the EGF-Receptor Protein Tyrosine Kinase

1994 • 88 citations

Recent advances in protein tyrosine kinase inhibitors

1995 • 42 citations

Patent Update: Oncologic, Endocrine & Metabolic Small molecule inhibitors of tyrosine kinase activity

1995 • 25 citations

Editorial Oncologic, Endocrine & Metabolic: The current status of tyrosine kinase inhibitors: Do the diarylamine inhibitors of the EGF receptor represent a new beginning?

1995 • 20 citations