Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Type 1 Neurofibromatosis Gene: Identification of a Large Transcript Disrupted in Three NF1 Patients

1990 • 1,471 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

DNA typing and genetic mapping with trimeric and tetrameric tandem repeats.

1991 • 1,170 citations

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

1990 • 1,107 citations

Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus

1990 • 1,085 citations

The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21

1990 • 984 citations

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1990 • 834 citations

Neurofibromatosis, Phenotype, Natural History, and Pathogenesis

1992 • 789 citations

The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae

1990 • 684 citations

A novel, rapid method for the isolation of terminal sequences from yeast artificial chromosome (YAC) clones

1990 • 650 citations

Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients

1992 • 648 citations

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

1992 • 583 citations

GENETICS OF HUMAN CANCER

1986 • 565 citations

Survey of human and rat microsatellites

1992 • 559 citations

Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis.

1990 • 407 citations

Somatic mutations in the neurofibromatosis 1 gene in human tumors

1992 • 399 citations

cDNA cloning of the type 1 neurofibromatosis gene: Complete sequence of the NF1 gene product

1991 • 391 citations

Paternal origin of new mutations in Von Recklinghausen neurofibromatosis

1990 • 204 citations

Loss of NF1 alleles in phaeochromocytomas from patients with type 1 neurofibromatosis

1992 • 157 citations

Molecular and cytogenetic analysis of tumors in von recklinghausen neurofibromatosis

1991 • 150 citations

Neurofibromatosis—phenotype, natural history and pathogenesis

1987 • 143 citations

Preferential mutation of the neurofibromatosis type 1 gene in paternally derived chromosomes

1992 • 129 citations

Molecular genetic analysis of tumors in von recklinghausen neurofibromatosis: Loss of heterozygosity for chromosome 17

1989 • 126 citations

The Gene Encoding the Oligodendrocyte-Myelin Glycoprotein Is Embedded within the Neurofibromatosis Type 1 Gene

1991 • 114 citations

cDNA sequence and genomic structure of EVI2B, a gene lying within an intron of the neurofibromatosis type 1 gene

1991 • 108 citations

The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene.

1991 • 91 citations

The human homolog of murine Evi-2 lies between two von Recklinghausen neurofibromatosis translocations

1990 • 75 citations

A yeast artificial chromosome contig encompassing the type 1 neurofibromatosis gene

1992 • 43 citations

NF1-related locus on chromosome 15

1992 • 43 citations

Characterization of a large deletion associated with a polymorphic block of repeated dinucleotides in the type III procollagen gene (COL3A1) of a patient with Ehlers-Danlos syndrome type IV.

1991 • 40 citations

Sequencing and analysis of genomic fragments from theNF1locus

1992 • 14 citations