Melphalan and Other Anticancer Modalities Up-Regulate B7-1 Gene Expression in Tumor Cells

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function.

1994 • 681 citations

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

1995 • 595 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Ionizing radiation induces expression and binding activity of the nuclear factor kappa B.

1991 • 410 citations

Induction of acute phase gene expression by brain irradiation

1995 • 338 citations

Costimulation of T cells for tumor immunity

1993 • 324 citations

Treatment of metastatic melanoma with an autologous tumor-cell vaccine: clinical and immunologic results in 64 patients.

1990 • 300 citations

Expression and functional significance of an additional ligand for CTLA-4.

1993 • 262 citations

Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide.

1986 • 255 citations

Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness

1997 • 251 citations

Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland.

1993 • 208 citations

Manipulation of costimulatory signals to enhance antitumor T-cell responses

1995 • 177 citations

A Critical Role for B7/CD28 Costimulation in Experimental Autoimmune Encephalomyelitis: A Comparative Study Using Costimulatory Molecule-Deficient Mice and Monoclonal Antibody Blockade

2000 • 160 citations

Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-kappa B.

1993 • 150 citations

Cyclophosphamide-induced immunologically mediated regression of a cyclophosphamide-resistant murine tumor: a consequence of eliminating precursor L3T4+ suppressor T-cells.

1989 • 149 citations

Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes.

1991 • 148 citations

Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?

1996 • 147 citations

A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-κB

1998 • 132 citations

E-Selectin Gene Induction by Ionizing Radiation Is Independent of Cytokine Induction

1995 • 128 citations

Tumor rejection requires a CTLA4 ligand provided by the host or expressed on the tumor: superiority of B7-1 over B7-2 for active tumor immunization.

1996 • 128 citations

B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro.

1996 • 123 citations

Cooperation between cyclophosphamide tumoricidal activity and host antitumor immunity in the cure of mice bearing large MOPC-315 tumors.

1981 • 100 citations

A cell type-specific enhancer in the human B7.1 gene regulated by NF-kappaB.

1996 • 83 citations

Immunization with haptenized, autologous tumor cells induces inflammation of human melanoma metastases.

1991 • 76 citations

Expression of cytokine mRNA in human melanoma tissues

1995 • 73 citations

Elimination of cycling CD4+ suppressor T cells with an anti-mitotic drug releases non-cycling CD8+ T cells to cause regression of an advanced lymphoma.

1990 • 71 citations

Increase in the effectiveness of melphalan therapy with progression of MOPC-315 plasmacytoma tumor growth

1983 • 60 citations

Low-dose melphalan-induced shift in the production of a Th2-type cytokine to a Th1-type cytokine in mice bearing a large MOPC-315 tumor

1994 • 55 citations

Specific immunotherapy with suppressor function inhibition for metastatic renal cell carcinoma.

1986 • 54 citations

B7-2 Expressed on EL4 Lymphoma Suppresses Antitumor Immunity by an Interleukin 4–dependent Mechanism

1999 • 52 citations

Host-mediated therapeutic effects produced by appropriately timed administration of bleomycin on a rat fibrosarcoma.

1985 • 46 citations

Transforming growth factor-?-mediated down-regulation of antitumor cytotoxicity of spleen cells from MOPC-315 tumor-bearing mice engaged in tumor eradication following low-dose melphalan therapy

1994 • 37 citations

Importance of Lyt 2+ T-cells in the curative effectiveness of a low dose of melphalan for mice bearing a large MOPC-315 tumor.

1989 • 36 citations

Importance of tumor-specific cytotoxic CD8+ T-cells in eradication of a large subcutaneous MOPC-315 tumor following low-dose melphalan therapy.

1990 • 33 citations

Enhancement of B7‐1 (CD80) expression on B‐lymphoma cells by irradiation

1999 • 32 citations

Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism.

1999 • 28 citations

Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule

1996 • 28 citations

Involvement of activator protein-1 and nuclear factor-kappaB transcription factors in the control of the DT-diaphorase expression induced by mitomycin C treatment.

1997 • 28 citations

Restoration of interleukin-2 production in tumor-bearing rats through reducing tumor-derived transforming growth factor β by treatment with bleomycin

1995 • 27 citations

Immunomodulation by various nitrosoureas and its effect on the survival of the murine host bearing a syngeneic tumor.

1989 • 27 citations

Augmentation of host antitumor immunity by low doses of cyclophosphamide and mafosfamide in two animal tumor models

1989 • 25 citations

Host B7-1 and B7-2 Costimulatory Molecules Contribute to the Eradication of B7-1-Transfected P815 Tumor Cells Via a CD8+ T Cell-Dependent Mechanism

1999 • 25 citations

Low-dose-melphalan-induced up-regulation of type-1 cytokine expression in the s.c. tumor nodule of MOPC-315 tumor bearers and the role of interferon γ in the therapeutic outcome

1995 • 22 citations

Importance of TNF production for the curative effectiveness of low dose melphalan therapy for mice bearing a large MOPC-315 tumor.

1995 • 22 citations

Importance of the B7-2 Molecule for Low Dose Melphalan-Induced Acquisition of Tumor-Eradicating Immunity by Mice Bearing a Large MOPC-315 Tumor

1998 • 22 citations

Regulation of NF-κB through the Nuclear Processing of p105 (NF-κB1) in Epstein-Barr Virus-immortalized B Cell Lines

1995 • 19 citations

Importance of B7-1-Expressing Host Antigen-Presenting Cells for the Eradication of B7-2 Transfected P815 Tumor Cells

1998 • 13 citations

Isolation and promoter mapping of the gene encoding murine co-stimulatory factor B7-1

1996 • 12 citations

Melphalan-induced enhancement of tumor cell immunostimulatory capacity as a mechanism for the appearance of potent antitumor immunity in the spleen of mice bearing a large metastatic MOPC-315 tumor

1985 • 11 citations

Potentiation of Antitumor CTL Response by GM-CSF Involves a B7-Dependent Mechanism

1997 • 10 citations

Cloning and partial characterization of the mouse B7-1 promoter

1996 • 3 citations

A Novel Stimulus, Oncogene, Induces Expression of CD80 (B7-1) Gene

1999 • 3 citations

Cloning and partial characterization of the mouseB7-1 promoter

1996 • 3 citations