Protein modules as organizers of membrane structure

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains

1997 • 1,371 citations

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

1998 • 1,331 citations

Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein

1998 • 1,147 citations

Homer: a protein that selectively binds metabotropic glutamate receptors

1997 • 1,058 citations

Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases

1995 • 994 citations

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

1991 • 902 citations

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

1997 • 866 citations

Binding of Neuroligins to PSD-95

1997 • 731 citations

Involvement of ZO-1 in Cadherin-based Cell Adhesion through Its Direct Binding to α Catenin and Actin Filaments

1997 • 659 citations

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade

1997 • 625 citations

SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family

1998 • 617 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange

1998 • 582 citations

Identification of EBP50: A PDZ-containing Phosphoprotein that Associates with Members of the Ezrin-Radixin-Moesin Family

1997 • 582 citations

MODULAR PEPTIDE RECOGNITION DOMAINS IN EUKARYOTIC SIGNALING

1997 • 558 citations

A Tripartite Protein Complex with the Potential to Couple Synaptic Vesicle Exocytosis to Cell Adhesion in Brain

1998 • 548 citations

Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1

1999 • 540 citations

Heteromultimerization and NMDA Receptor-Clustering Activity of Chapsyn-110, a Member of the PSD-95 Family of Proteins

1996 • 539 citations

CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins

1996 • 534 citations

The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

1998 • 530 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

GKAP, a Novel Synaptic Protein That Interacts with the Guanylate Kinase-like Domain of the PSD-95/SAP90 Family of Channel Clustering Molecules

1997 • 503 citations

PDZ Proteins Organize Synaptic Signaling Pathways

1998 • 474 citations

Afadin: A Novel Actin Filament–binding Protein with One PDZ Domain Localized at Cadherin-based Cell-to-Cell Adherens Junction

1997 • 473 citations

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

1999 • 469 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands

1998 • 455 citations

Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

1994 • 452 citations

cAMP-mediated inhibition of the epithelial brush border Na ⁺ /H ⁺ exchanger, NHE3, requires an associated regulatory protein

1997 • 426 citations

SAP102, a Novel Postsynaptic Protein That Interacts with NMDA Receptor Complexes In Vivo

1996 • 422 citations

Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia.

1996 • 422 citations

Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium

1988 • 419 citations

Human CASK/LIN-2 Binds Syndecan-2 and Protein 4.1 and Localizes to the Basolateral Membrane of Epithelial Cells

1998 • 376 citations

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N -methyl- <scp>d</scp> -aspartate receptor subunit NR2A

1999 • 369 citations

The LIN-2/LIN-7/LIN-10 Complex Mediates Basolateral Membrane Localization of the C. elegans EGF Receptor LET-23 in Vulval Epithelial Cells

1998 • 366 citations

Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

1994 • 365 citations

Regulation of cortical structure by the ezrin-radixin-moesin protein family

1999 • 365 citations

Neurexins: Three genes and 1001 products

1998 • 359 citations

Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger.

1995 • 344 citations

Direct Interaction of CASK/LIN-2 and Syndecan Heparan Sulfate Proteoglycan and Their Overlapping Distribution in Neuronal Synapses

1998 • 342 citations

The Ras Target AF-6 Interacts with ZO-1 and Serves as a Peripheral Component of Tight Junctions in Epithelial Cells

1997 • 315 citations

Ezrin is a cyclic AMP-dependent protein kinase anchoring protein

1997 • 309 citations

CRIPT, a Novel Postsynaptic Protein that Binds to the Third PDZ Domain of PSD-95/SAP90

1998 • 304 citations

The drosophila tumor suppressor gene dlg is required for normal synaptic bouton structure

1994 • 301 citations

Requirement for the PDZ Domain Protein, INAD, for Localization of the TRP Store-Operated Channel to a Signaling Complex

1997 • 292 citations

Peptide binding consensus of the NHE‐RF‐PDZ1 domain matches the C‐terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)

1998 • 278 citations

Molecular mechanisms of glutamate receptor clustering at excitatory synapses

1998 • 273 citations

LET-23 Receptor Localization by the Cell Junction Protein LIN-7 during C. elegans Vulval Induction

1996 • 268 citations

Binding of the Inward Rectifier K+ Channel Kir 2.3 to PSD-95 Is Regulated by Protein Kinase A Phosphorylation

1996 • 265 citations

Essential Role fordlgin Synaptic Clustering of Shaker K⁺ChannelsIn Vivo

1997 • 262 citations

SAP90 Binds and Clusters Kainate Receptors Causing Incomplete Desensitization

1998 • 261 citations

Regulation of the TRP Ca2+ Channel by INAD in Drosophila Photoreceptors

1996 • 256 citations

Cell signalling: MAGUK magic

1996 • 248 citations

The Carboxyl Terminus of B Class Ephrins Constitutes a PDZ Domain Binding Motif

1999 • 244 citations

From Src Homology domains to other signaling modules: proposal of the `protein recognition code'

1998 • 232 citations

Coordination of an Array of Signaling Proteins through Homo- and Heteromeric Interactions Between PDZ Domains and Target Proteins

1998 • 215 citations

Neurabin-II/Spinophilin

1998 • 211 citations

Synaptic Clustering of Fasciclin II and Shaker: Essential Targeting Sequences and Role of Dlg

1997 • 208 citations

Synaptic Clustering of the Cell Adhesion Molecule Fasciclin II by Discs-Large and its Role in the Regulation of Presynaptic Structure

1997 • 208 citations

Disulfide-Linked Head-to-Head Multimerization in the Mechanism of Ion Channel Clustering by PSD-95

1997 • 207 citations

The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.

1996 • 204 citations

Identification of an Evolutionarily Conserved Heterotrimeric Protein Complex Involved in Protein Targeting

1998 • 193 citations

Citron Binds to PSD-95 at Glutamatergic Synapses on Inhibitory Neurons in the Hippocampus

1999 • 186 citations

Plasma Membrane Ca2+ ATPase Isoform 4b Binds to Membrane-associated Guanylate Kinase (MAGUK) Proteins via Their PDZ (PSD-95/Dlg/ZO-1) Domains

1998 • 155 citations

Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses

1998 • 148 citations

Cortactin Associates with the Cell-Cell Junction Protein ZO-1 in both Drosophila and Mouse

1998 • 141 citations

PDZ Motifs in PTP-BL and RIL Bind to Internal Protein Segments in the LIM Domain Protein RIL

1998 • 138 citations

Subcellular targeting and cytoskeletal attachment of SAP97 to the epithelial lateral membrane

1998 • 137 citations

Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD

1999 • 126 citations

Identification and partial characterization of PDZK1: a novel protein containing PDZ interaction domains.

1998 • 125 citations

A novel protein encoded by the inad gene regulates recovery of visual transduction in drosophila

1995 • 117 citations

TRP trapped in fly signaling web

1998 • 114 citations

Tight junctions, membrane-associated guanylate kinases and cell signaling

1995 • 112 citations

Basolateral Localization of theCaenorhabditis elegansEpidermal Growth Factor Receptor in Epithelial Cells by the PDZ Protein LIN-10

1999 • 107 citations

Citron, a Rho-Target, Interacts with PSD-95/SAP-90 at Glutamatergic Synapses in the Thalamus

1999 • 98 citations

Organization of kinases, phosphatases, and receptor signaling complexes

1999 • 98 citations

BEGAIN (Brain-enriched Guanylate Kinase-associated Protein), a Novel Neuronal PSD-95/SAP90-binding Protein

1998 • 90 citations

Interaction of NE-dlg/SAP102, a Neuronal and Endocrine Tissue-specific Membrane-associated Guanylate Kinase Protein, with Calmodulin and PSD-95/SAP90

1999 • 88 citations

Requirement of N-terminal Cysteines of PSD-95 for PSD-95 Multimerization and Ternary Complex Formation, but Not for Binding to Potassium Channel Kv1.4

1999 • 83 citations

Association of INAD with NORPA is essential for controlled activation and deactivation of Drosophila phototransduction in vivo

1997 • 77 citations

Cytoplasmic signalling domains: the next generation

1997 • 56 citations