Megakaryocytes express functional Aurora-B kinase in endomitosis

Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

1999 • 1,684 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

2003 • 1,144 citations

Centromeres and Kinetochores

2003 • 967 citations

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • 847 citations

Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5

2000 • 704 citations

Cyclin E Ablation in the Mouse

2003 • 640 citations

Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases

2002 • 636 citations

Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis

2001 • 616 citations

Chromosomal passengers and the (aurora) ABCs of mitosis

2001 • 535 citations

Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

2000 • 534 citations

Exploring the Functional Interactions between Aurora B, INCENP, and Survivin in Mitosis

2003 • 495 citations

Essential Roles of Drosophila Inner Centromere Protein (Incenp) and Aurora B in Histone H3 Phosphorylation, Metaphase Chromosome Alignment, Kinetochore Disjunction, and Chromosome Segregation

2001 • 457 citations

Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity

2004 • 443 citations

The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis.

1987 • 407 citations

The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

1999 • 404 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.

1998 • 324 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

Aurora B Kinase Exists in a Complex with Survivin and INCENP and Its Kinase Activity Is Stimulated by Survivin Binding and Phosphorylation

2002 • 318 citations

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

2001 • 317 citations

Inhibition of Aurora B Kinase Blocks Chromosome Segregation, Overrides the Spindle Checkpoint, and Perturbs Microtubule Dynamics in Mitosis

2002 • 307 citations

INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow

2000 • 307 citations

Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis

2000 • 301 citations

INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis

2001 • 261 citations

Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis

1999 • 222 citations

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

1995 • 218 citations

Chromosomal passengers: Toward an integrated view of mitosis

1991 • 198 citations

Probing the Dynamics and Functions of Aurora B Kinase in Living Cells during Mitosis and Cytokinesis

2002 • 195 citations

Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division

1999 • 194 citations

The Kinase Activity of Aurora B Is Required for Kinetochore-Microtubule Interactions during Mitosis

2002 • 188 citations

BUBR1 deficiency results in abnormal megakaryopoiesis

2003 • 182 citations

Endomitosis of Human Megakaryocytes Are Due to Abortive Mitosis

1998 • 178 citations

Analysis of the distribution of the INCENPs throughout mitosis reveals the existence of a pathway of structural changes in the chromosomes during metaphase and early events in cleavage furrow formation

1991 • 176 citations

Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain

1997 • 158 citations

A Dominant Mutant of Inner Centromere Protein (INCENP), a Chromosomal Protein, Disrupts Prometaphase Congression and Cytokinesis

1998 • 151 citations

A Novel Mammalian, Mitotic Spindle–associated Kinase Is Related to Yeast and Fly Chromosome Segregation Regulators

1997 • 138 citations

Aurora-B Phosphorylation in Vitro Identifies a Residue of Survivin That Is Essential for Its Localization and Binding to Inner Centromere Protein (INCENP) in Vivo

2004 • 130 citations

A Role for Cyclin D3 in the Endomitotic Cell Cycle

1997 • 121 citations

Cyclin D3 is essential for megakaryocytopoiesis

1995 • 120 citations

Two-color flow cytometric measurement of DNA distributions of rat megakaryocytes in unfixed, unfractionated marrow cell suspensions

1984 • 118 citations

The Cell Cycle in Polyploid Megakaryocytes Is Associated with Reduced Activity of Cyclin B1-dependent Cdc2 Kinase

1996 • 113 citations

Maturation of the head of bacteriophage T4

1974 • 110 citations

Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase Cα

2001 • 88 citations

Defective chromosome segregation, microtubule bundling and nuclear bridging in inner centromere protein gene (Incenp)-disrupted mice

1999 • 86 citations

Cleavage Furrows Formed between Centrosomes Lacking an Intervening Spindle and Chromosomes Contain Microtubule Bundles, INCENP, and CHO1 but Not CENP-E

1999 • 78 citations

Advances in Cytokinesis Research. Role of Chromosomal Passenger Complex in Chromosome Segregation and Cytokinesis.

2001 • 77 citations

Role of p21Cip1/Waf1 in cell-cycle exit of endomitotic megakaryocytes

2001 • 71 citations

Myosin II Regulatory Light Chain as a Novel Substrate for AIM-1, an Aurora/Ipl1p-related Kinase from Rat

2000 • 70 citations

Do Centrosome Abnormalities Lead to Cancer?

2001 • 70 citations

Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1–deregulated expression

2004 • 68 citations

Genomic Organization, Expression, and Chromosome Localization of a Third Aurora-Related Kinase Gene,Aie1

2000 • 68 citations

pEg2 Aurora-A Kinase, Histone H3 Phosphorylation, and Chromosome Assembly in Xenopus Egg Extract

2001 • 58 citations

Downregulation of an Aim-1 Kinase Couples with Megakaryocytic Polyploidization of Human Hematopoietic Cells

2001 • 58 citations

Hypothesis: The telophase disc: Its possible role in mammalian cell cleavage

1993 • 51 citations

Asymmetrical segregation of chromosomes with a normal metaphase/anaphase checkpoint in polyploid megakaryocytes

2001 • 50 citations

Overexpression of cyclin D1 moderately increases ploidy in megakaryocytes.

2001 • 43 citations

Increased D-type Cyclin Expression Together with Decreased cdc2 Activity Confers Megakaryocytic Differentiation of a Human Thrombopoietin-dependent Hematopoietic Cell Line

2000 • 37 citations

Kinetics of endomitosis in primary murine megakaryocytes

2001 • 31 citations

Human AIM-1: cDNA cloning and reduced expression during endomitosis in megakaryocyte-lineage cells

1998 • 22 citations

Repression of AIM-1 Kinase mRNA as Part of a Program of Genes Regulated by Mpl Ligand

2001 • 11 citations

Cyclins and cell division kinases in megakaryocytic endomitosis.

1995 • 7 citations