AuroraA overexpression overrides the mitotic spindle checkpoint triggered by nocodazole, a microtubule destabilizer

Genetic instabilities in human cancers

1998 • 4,165 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

1995 • 1,407 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

2001 • 877 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

2003 • 615 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

Chromosomal passengers and the (aurora) ABCs of mitosis

2001 • 535 citations

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1997 • 483 citations

Mad2-Independent Inhibition of APCCdc20 by the Mitotic Checkpoint Protein BubR1

2001 • 416 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

Human Bubr1 Is a Mitotic Checkpoint Kinase That Monitors Cenp-E Functions at Kinetochores and Binds the Cyclosome/APC

1999 • 379 citations

Checkpoint Protein BubR1 Acts Synergistically with Mad2 to Inhibit Anaphase-promoting Complex

2002 • 332 citations

Inhibition of Aurora B Kinase Blocks Chromosome Segregation, Overrides the Spindle Checkpoint, and Perturbs Microtubule Dynamics in Mitosis

2002 • 307 citations

Amplification/Overexpression of a Mitotic Kinase Gene in Human Bladder Cancer

2002 • 303 citations

Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

1993 • 301 citations

Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit

2002 • 295 citations

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

2000 • 281 citations

Characterization of the Kinetochore Binding Domain of CENP-E Reveals Interactions with the Kinetochore Proteins CENP-F and hBUBR1

1998 • 280 citations

Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

2001 • 211 citations

Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells

2002 • 208 citations

Probing the Dynamics and Functions of Aurora B Kinase in Living Cells during Mitosis and Cytokinesis

2002 • 195 citations

Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers

1999 • 124 citations

The spindle checkpoint

1998 • 113 citations

Mutational Inactivation of Mitotic Checkpoint Genes, hsMAD2 and hBUB1, Is Rare in Sporadic Digestive Tract Cancers

1999 • 99 citations

Molecular analyses of the mitotic checkpoint componentshsMAD2, hBUB1 andhBUB3 in human cancer

2001 • 92 citations

Identification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation

2001 • 92 citations

Cloning of STK13, a Third Human Protein Kinase Related toDrosophilaAurora and Budding Yeast Ipl1 That Maps on Chromosome 19q13.3–ter

1998 • 89 citations

Cdc20 associates with the kinase aurora2/Aik

1999 • 68 citations

The Xenopus laevis Aurora/Ip11p-Related Kinase pEg2 Participates in the Stability of the Bipolar Mitotic Spindle

2000 • 67 citations

Infrequent Mutation of the hBUB1 and hBUBR1 Genes in Human Lung Cancer

2000 • 66 citations

Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1

2002 • 65 citations

Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas

2001 • 31 citations

Japan split over US aid for spy satellites

1998 • 18 citations

The control of mitosis

2000 • 6 citations