Novel Pathways and Endogenous Mediators in Anti-Inflammation and Resolution

Inflammation. Basic principles and clinical correlates

1989 • 2,424 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

2002 • 1,963 citations

Resolvins

2002 • 1,575 citations

Lipid mediator class switching during acute inflammation: signals in resolution

2001 • 1,355 citations

Prostaglandin synthase 2

1996 • 1,212 citations

Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

2000 • 1,136 citations

Aspirin and the Risk of Colorectal Cancer in Women

1995 • 1,116 citations

Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.

1984 • 728 citations

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.

1995 • 694 citations

Cutting Edge: Lipoxins Rapidly Stimulate Nonphlogistic Phagocytosis of Apoptotic Neutrophils by Monocyte-Derived Macrophages

2000 • 620 citations

Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor.

1994 • 431 citations

Lipid mediator networks in cell signaling: update and impact of cytokines ¹

1996 • 401 citations

Reduced Inflammation and Tissue Damage in Transgenic Rabbits Overexpressing 15-Lipoxygenase and Endogenous Anti-inflammatory Lipid Mediators

2003 • 392 citations

Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits

2000 • 389 citations

Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A4

2002 • 356 citations

Effect of Cyclooxygenase-2 Inhibition on Renal Function in Elderly Persons Receiving a Low-Salt Diet

2000 • 332 citations

Cells, tissues, and disease : principles of general pathology

1996 • 306 citations

Atherosclerosis: The New View

2002 • 303 citations

Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.

1990 • 297 citations

Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum?

2002 • 295 citations

Prostaglandin H synthases, nonsteroidal antiinflammatory drugs, and colon cancer

1997 • 290 citations

Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: selective inactivation by dehydrogenation and reduction.

1996 • 288 citations

Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia

2002 • 287 citations

Rofecoxib, a specific inhibitor of cyclooxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: Results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip

2000 • 282 citations

Lipoxin biosynthesis and its impact in inflammatory and vascular events

1994 • 275 citations

Lipoxin A4 Stable Analogs Are Potent Mimetics That Stimulate Human Monocytes and THP-1 Cells via a G-protein-linked Lipoxin A4 Receptor

1997 • 266 citations

Activation of Lipoxin a4 Receptors by Aspirin-Triggered Lipoxins and Select Peptides Evokes Ligand-Specific Responses in Inflammation

2000 • 262 citations

Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity

2001 • 260 citations

Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis

2002 • 257 citations

Pharmacology of montelukast sodium (Singulair™), a potent and selective leukotriene D₄receptor antagonist

1995 • 252 citations

Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): A jungle of cell-cell interactions or a therapeutic opportunity?

1997 • 243 citations

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.

1996 • 234 citations

Neutrophil-mediated changes in vascular permeability are inhibited by topical application of aspirin-triggered 15-epi-lipoxin A4 and novel lipoxin B4 stable analogues.

1998 • 231 citations

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

1994 • 231 citations

The discovery of aspirin: a reappraisal

2000 • 230 citations

Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion

1999 • 219 citations

Lipoxin A4 Inhibits IL-1β-Induced IL-6, IL-8, and Matrix Metalloproteinase-3 Production in Human Synovial Fibroblasts and Enhances Synthesis of Tissue Inhibitors of Metalloproteinases

2000 • 216 citations

Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis

2000 • 213 citations

Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitmentin vivo

1999 • 209 citations

Lipoxin A₄Analogues Inhibit Leukocyte Recruitment toPorphyromonas gingivalis: A Role for Cyclooxygenase-2 and Lipoxins in Periodontal Disease

2000 • 201 citations

Lipoxin (LX)A4 and Aspirin-triggered 15-epi-LXA4 Inhibit Tumor Necrosis Factor 1α–initiated Neutrophil Responses and Trafficking: Regulators of a Cytokine–Chemokine Axis

1999 • 198 citations

Human alveolar macrophages have 15-lipoxygenase and generate 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid and lipoxins.

1993 • 196 citations

Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy.

1992 • 194 citations

Aspirin-Triggered Lipoxins (15-epi-LX) Are Generated by the Human Lung Adenocarcinoma Cell Line (A549)–Neutrophil Interactions and Are Potent Inhibitors of Cell Proliferation

1996 • 189 citations

Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils.

1990 • 180 citations

Oxidoreductases in Lipoxin A4 Metabolic Inactivation

2000 • 179 citations

Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics

2000 • 176 citations

Selectivity of Recombinant Human Leukotriene D4, Leukotriene B4, and Lipoxin A4 Receptors with Aspirin-Triggered 15-epi-LXA4 and Regulation of Vascular and Inflammatory Responses

2001 • 167 citations

Vitamin C prevents cigarette smoke-induced leukocyte aggregation and adhesion to endothelium in vivo.

1994 • 167 citations

Selective incorporation of (15S)-hydroxyeicosatetraenoic acid in phosphatidylinositol of human neutrophils: agonist-induced deacylation and transformation of stored hydroxyeicosanoids.

1990 • 164 citations

Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs.

1998 • 162 citations

Novel Lipid Mediator Regulators of Endothelial Cell Proliferation and Migration: Aspirin-Triggered-15R-Lipoxin A₄and Lipoxin A₄

2002 • 159 citations

Lipoxin A4 antagonizes cellular and in vivo actions of leukotriene D4 in rat glomerular mesangial cells: evidence for competition at a common receptor.

1989 • 153 citations

Transfection of rat kidney with human 15-lipoxygenase suppresses inflammation and preserves function in experimental glomerulonephritis

1999 • 149 citations

TH2 and ‘TH2-like’ cells in allergy and asthma: pharmacological perspectives

1994 • 147 citations

Time course of inflammatory and remodeling events in a murine model of asthma: effect of steroid treatment

2000 • 144 citations

15-Epi-16-(Para-Fluorophenoxy)-Lipoxin A4-Methyl Ester, a Synthetic Analogue of 15-epi-Lipoxin A4, Is Protective in Experimental Ischemic Acute Renal Failure

2002 • 142 citations

Lipoxins Are Potential Endogenous Antiinflammatory Mediators in Asthma

2002 • 139 citations

Identification of Lipoxin A₄and Its Relationship to the Sulfidopeptide Leukotrienes C₄, D₄, and E₄in the Bronchoalveolar Lavage Fluids Obtained from Patients with Selected Pulmonary Diseases

1990 • 133 citations

Cyclooxygenase-2-Derived Prostaglandin E2 and Lipoxin A4 Accelerate Resolution of Allergic Edema inAngiostrongylus costaricensis-Infected Rats: Relationship with Concurrent Eosinophilia

2000 • 129 citations

Analysis of Hydroperoxide-Induced Tyrosyl Radicals and Lipoxygenase Activity in Aspirin-Treated Human Prostaglandin H Synthase-2

1997 • 122 citations

P-selectin mediates the interaction of circulating leukocytes with platelets and microvascular endothelium in response to oxidized lipoprotein in vivo.

1994 • 122 citations

Transcellular biosynthesis of lipoxin A4 during adhesion of platelets and neutrophils in experimental immune complex glomerulonephritis

1995 • 120 citations

Diverging signal transduction pathways activated by interleukin-8 and related chemokines in human neutrophils: interleukin-8, but not NAP-2 or GRO alpha, stimulates phospholipase D activity

1995 • 112 citations

Cutting Edge: Nociceptin Stimulates Neutrophil Chemotaxis and Recruitment: Inhibition by Aspirin-Triggered-15-Epi-Lipoxin A4

2001 • 106 citations

Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA.

1998 • 103 citations

Transcellular conversion of endogenous arachidonic acid to lipoxins in mixed human platelet-granulocyte suspensions

1988 • 101 citations

Molecular and Cellular Basis of Inflammation

1999 • 101 citations

Granulocyte/macrophage colony-stimulating factor stimulates the expression of the 5-lipoxygenase-activating protein (FLAP) in human neutrophils.

1994 • 98 citations

Anti-Inflammatory Actions of Lipoxin A4 Stable Analogs Are Demonstrable in Human Whole Blood: Modulation of Leukocyte Adhesion Molecules and Inhibition of Neutrophil-Endothelial Interactions

1999 • 91 citations

Lipoxin B₄regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B₄analogs with increased biologic activity

1998 • 89 citations

Lipoxin synthase activity of human platelet 12-lipoxygenase

1993 • 86 citations

Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice

1996 • 86 citations

5(S),15(S)-dihydroxyeicosatetraenoic acid and lipoxin generation in human polymorphonuclear cells: dual specificity of 5-lipoxygenase towards endogenous and exogenous precursors.

1996 • 82 citations

Lipoxin generation by permeabilized human platelets

1992 • 82 citations

Adhesion promotes transcellular leukotriene biosynthesis during neutrophil-glomerular endothelial cell interactions: Inhibition by antibodies against CD18 and L-selectin

1992 • 79 citations

Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: Structure-function relationships

1991 • 77 citations

Lipoxin formation in human nasal polyps and bronchial tissue

1990 • 75 citations

Suppression of Leukotriene B4 Biosynthesis by Endogenous Adenosine in Ligand-activated Human Neutrophils

1997 • 74 citations

Lipoxin A4 and Aspirin-Triggered 15-Epi-Lipoxin A4 Antagonize TNF-α-Stimulated Neutrophil-Enterocyte Interactions In Vitro and Attenuate TNF-α-Induced Chemokine Release and Colonocyte Apoptosis in Human Intestinal Mucosa Ex Vivo

2001 • 73 citations

Arachidonate 15-lipoxygenase; characteristics and potential biological significance.

1991 • 72 citations

Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites

1998 • 66 citations

LXA₄, aspirin-triggered 15-epi-LXA₄, and their analogs selectively downregulate PMN azurophilic degranulation

1999 • 66 citations

COX Inhibitors and Thromboregulation

2002 • 66 citations

Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse

1996 • 65 citations

Aspirin‐triggered lipoxin A ₄ and lipoxin A ₄ up‐regulate transcriptional corepressor NAB1 in human neutrophils

2001 • 64 citations

Deficient lipoxin synthesis: a novel platelet dysfunction in myeloproliferative disorders with special reference to blastic crisis of chronic myelogenous leukemia

1991 • 60 citations

Lymphocytes stimulate expression of 5-lipoxygenase and its activating protein in monocytes in vitro via granulocyte macrophage colony-stimulating factor and interleukin 3.

1996 • 57 citations

The Benefits of Aspirin in Acute Myocardial Infarction

1994 • 54 citations

Formation and proliferative effects of lipoxins in human bone marrow

1991 • 53 citations

The Scent of a Phagocyte

2000 • 52 citations

Agonist‐induced lipoxin A₄ generation: Detection by a novel lipoxin A₄‐ELISA

1993 • 52 citations

Conversion of endogenous arachidonic acid to 5,15-diHETE and lipoxins by polymorphonuclear cells from patients with rheumatoid arthritis

1995 • 51 citations

Lipoxins A4 and B4: comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity.

1988 • 49 citations

Haemostasis in Fish – An Evolutionary Perspective

1997 • 48 citations

Lipoxin generation by human megakaryocyte-induced 12-lipoxygenase

1992 • 45 citations

IMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment

2000 • 45 citations

On the mechanism of transcellular lipoxin formation in human platelets and granulocytes

1991 • 44 citations

Regulation of Leukocyte Trafficking by Lipoxins

1999 • 36 citations

5-15-DiHETE and Lipoxins Generated by Neutrophils from Endogenous Arachidonic Acid as Asthma Biomarkers

1995 • 32 citations

Urinary Excretion of Lipoxin A4 and Related Compounds: Development of New Extraction Techniques for Lipoxins

2002 • 31 citations

Leukotrienes and lipoxins—New potential performers in the regulation of human myelopoiesis

1994 • 29 citations

Lipoxins: Bioactive Lipoxygenase Interaction Products

1991 • 26 citations

Recent Progress in the Cellular and Molecular Biology of Prostaglandin Synthesis

1998 • 21 citations

Conversion of 5,6‐dihydroxyeicosatetraenoic acids A novel pathway for lipoxin formation by human platelets

1992 • 17 citations

Human 15-lipoxygenase: a potential effector molecule for interleukin-4.

1994 • 13 citations

The Lipoxin Biosynthetic Circuit and their Actions with Human Neutrophils

1991 • 12 citations

Identification of a human enterocyte lipoxin a receptor that is regulated by IL-13 and IFN-γ and inhibits TNF-α-induced IL-8 release

1999 • 4 citations