Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum?

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression

2002 • 1,963 citations

Gastrointestinal Toxicity of Nonsteroidal Antiinflammatory Drugs

1999 • 1,942 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1996 • 1,773 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

1999 • 1,488 citations

Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

2001 • 1,271 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis

1996 • 829 citations

Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol)

1972 • 773 citations

Cyclooxygenase-2: A Therapeutic Target

2002 • 656 citations

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

1996 • 618 citations

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

1992 • 498 citations

Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.

2001 • 450 citations

Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor

1997 • 326 citations

Cyclo‐oxygenase‐2: pharmacology, physiology, biochemistry and relevance to NSAID therapy

1999 • 318 citations

Antipyretics: mechanisms of action and clinical use in fever suppression

2001 • 314 citations

Endothelial cells of the rat brain vasculature express cyclooxygenase-2 mRNA in response to systemic interleukin-1β: a possible site of prostaglandin synthesis responsible for fever

1996 • 309 citations

The Spinal Phospholipase-Cyclooxygenase-Prostanoid Cascade in Nociceptive Processing

2002 • 302 citations

The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2−/−, but not in cyclooxygenase-1−/− mice

1999 • 269 citations

Efficacy of celecoxib, a cyclooxygenase 2-specific inhibitor, in the treatment of ankylosing spondylitis: A six-week controlled study with comparison against placebo and against a conventional nonsteroidal antiinflammatory drug

2001 • 247 citations

Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H ₂ synthases

2002 • 216 citations

Paracetamol

2000 • 201 citations

Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs

1999 • 149 citations

Valdecoxib, a COX-2???Specific Inhibitor, Is an Efficacious, Opioid-Sparing Analgesic in Patients Undergoing Hip Arthroplasty

2002 • 143 citations

Cardiovascular pharmacology of nonselective nonsteroidal anti-inflammatory drugs and coxibs: clinical considerations

2002 • 130 citations

From studies of biochemical mechanism to novel biological mediators: Prostaglandin endoperoxides, thromboxanes, and leukotriences

1983 • 126 citations

Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: Replicate clinical trials in a tissue injury model*

2002 • 114 citations

The fight against rheumatism: from willow bark to COX-1 sparing drugs.

2000 • 111 citations

Pronounced reduction of in vivo prostacyclin synthesis in humans by acetaminophen (paracetamol)

1989 • 106 citations

The fight against rheumatism: from willow bark to COX-1 sparing drugs.

2000 • 101 citations

Up‐regulation of COX‐2 by inhibition of COX‐1 in the rat: a key to NSAID‐induced gastric injury

2002 • 91 citations

Aspirin: new cardiovascular uses for an old drug

2001 • 86 citations

Pharmacology of cyclooxygenase-2 inhibition in the kidney

2002 • 80 citations

Comparison of the analgesic efficacy of rofecoxib and enteric-coated diclofenac sodium in the treatment of postoperative dental pain: A randomized, placebo-controlled clinical trial

2002 • 80 citations

Paracetamol-inhibitable COX-2.

2000 • 32 citations