Recent Progress in the Cellular and Molecular Biology of Prostaglandin Synthesis

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Prostaglandin synthase 2

1996 • 1,212 citations

PRIMARY RESPONSE GENES INDUCED BY GROWTH FACTORS AND TUMOR PROMOTERS

1991 • 1,078 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions.

1995 • 694 citations

Transcriptional Roles of Nuclear Factor κB and Nuclear Factor-Interleukin-6 in the Tumor Necrosis Factor α-Dependent Induction of Cyclooxygenase-2 in MC3T3-E1 Cells

1995 • 657 citations

Prostaglandin endoperoxide synthase: structure and catalysis

1991 • 607 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

1991 • 571 citations

Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase.

1992 • 498 citations

Transcriptional Regulation of Human Prostaglandin-endoperoxide Synthase-2 Gene by Lipopolysaccharide and Phorbol Ester in Vascular Endothelial Cells

1995 • 487 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene.

1992 • 412 citations

Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.

1994 • 366 citations

Cloning of tetradecanoyl phorbol ester-induced 'primary response' sequences and their expression in density-arrested Swiss 3T3 cells and a TPA non-proliferative variant.

1987 • 360 citations

v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor

1995 • 295 citations

Transcriptional Regulation of Prostaglandin Synthase 2 Gene Expression by Platelet-derived Growth Factor and Serum

1996 • 244 citations

Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages.

1994 • 243 citations

Primary structure of sheep prostaglandin endoperoxide synthase deduced from cDNA sequence

1988 • 217 citations

v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element.

1994 • 207 citations

Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells.

1992 • 191 citations

Aspirin-Triggered Lipoxins (15-epi-LX) Are Generated by the Human Lung Adenocarcinoma Cell Line (A549)–Neutrophil Interactions and Are Potent Inhibitors of Cell Proliferation

1996 • 189 citations

Prostaglandin Synthase-1 and Prostaglandin Synthase-2 Are Coupled to Distinct Phospholipases for the Generation of Prostaglandin D2 in Activated Mast Cells

1997 • 175 citations

CYCLOOXYGENASE-2 INHIBITORS

1996 • 165 citations

Analysis of the Secretory Phospholipase A2 That Mediates Prostaglandin Production in Mast Cells

1997 • 164 citations

Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells

1994 • 148 citations

Evidence that secretory phospholipase A2 plays a role in arachidonic acid release and eicosanoid biosynthesis by mast cells.

1994 • 132 citations

Transcellular Prostaglandin Production following Mast Cell Activation Is Mediated by Proximal Secretory Phospholipase A2 and Distal Prostaglandin Synthase 1

1996 • 113 citations

Differential Regulation of Cyclo-Oxygenase-1 and Cyclo-Oxygenase-2 Gene Expression by Lipopolysaccharide Treatment in vivo in the Rat

1996 • 101 citations

A Heparin-sensitive Phospholipase A2 and Prostaglandin Endoperoxide Synthase-2 Are Functionally Linked in the Delayed Phase of Prostaglandin D2 Generation in Mouse Bone Marrow-derived Mast Cells

1996 • 96 citations

Mutation of serine‐516 in human prostaglandin G/H synthase‐2 to methionine or aspirin acetylation of this residue stimulates 15‐R‐HETE synthesis

1994 • 94 citations

IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2.

1995 • 87 citations

Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity.

1992 • 85 citations

Prostaglandin synthase 1 and prostaglandin synthase 2 both participate in activation-induced prostaglandin D2 production in mast cells.

1995 • 70 citations

Closing In on a Stomach-Sparing Aspirin Substitute

1996 • 11 citations