Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.

Beyond Cholesterol

1989 • 6,533 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Low density lipoprotein undergoes oxidative modification in vivo.

1989 • 1,537 citations

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

1992 • 1,332 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia.

1987 • 885 citations

Malondialdehyde-Altered Protein Occurs in Atheroma of Watanabe Heritable Hyperlipidemic Rabbits

1988 • 757 citations

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

1990 • 429 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

1992 • 382 citations

The antioxidant butylated hydroxytoluene protects against atherosclerosis.

1991 • 362 citations

Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification

1988 • 301 citations

Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice.

1990 • 289 citations

Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages

1991 • 223 citations

Molecular cloning and primary structure of human 15-lipoxygenase

1988 • 214 citations

Low density lipoprotein is protected from oxidation and the progression of atherosclerosis is slowed in cholesterol-fed rabbits by the antioxidant N,N'-diphenyl-phenylenediamine.

1992 • 207 citations

Involvement of 15-lipoxygenase in early stages of atherogenesis.

1994 • 196 citations

13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX.

1985 • 196 citations

Selected methodologic aspects of the International Atherosclerosis Project.

1968 • 172 citations

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

1994 • 132 citations

Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.

1995 • 130 citations

Enhanced Levels of Lipoperoxides in Low Density Lipoprotein Incubated with Murine Fibroblasts Expressing High Levels of Human 15-Lipoxygenase

1995 • 107 citations

Topographic study of sudanophilic lesions in cholesterol-fed minipigs by image analysis.

1985 • 90 citations

Endothelial Cells Produce a Lipoxygenase Derived Chemo-Repellent which Influences Platelet/Endothelial Cell Interactions – Effect of Aspirin and Salicylate

1985 • 79 citations

In vivo gene therapy for hyperlipidemia: phenotypic correction in Watanabe rabbits by hepatic delivery of the rabbit LDL receptor gene.

1995 • 72 citations

Lipoprotein modification

1994 • 71 citations

Mechanisms of oxidation, antioxidants, and atherosclerosis

1994 • 66 citations

Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promoter: macrophage-specific expression and variable positional specificity of the transgenic enzyme.

1995 • 57 citations

13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells

1987 • 52 citations

13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets

1987 • 48 citations

The induced lipoxygenase in atherosclerotic aorta converts linoleic acid to the platelet chemorepellant factor 13-hode

1989 • 46 citations

Binding of 13-HODE and 5-, 12- and 15-HETE to endothelial cells and subsequent platelet, neutrophil and tumor cell adhesion

1988 • 42 citations

The binding of monomeric IgG to human blood monocytes and alveolar macrophages.

1986 • 23 citations

Antioxidants and atherosclerosis progression: unresolved questions

1994 • 21 citations

Relationship of vascular 15-lipoxygenase induction to atherosclerotic plaque formation in rabbits

1990 • 11 citations