Immunophenotypic and Immunogenotypic Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia

Avoiding false positives with PCR

1989 • 3,564 citations

Bone marrow transplant

1989 • 3,423 citations

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Protides of the Biological Fluids

1969 • 1,623 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all

1990 • 726 citations

Protides of Biological Fluids

1971 • 471 citations

Detection of Minimal Residual Cells Carrying the t(14;18) by DNA Sequence Amplification

1987 • 426 citations

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

1987 • 405 citations

Differentiation-Linked Leukemogenesis in Lymphocytes

1986 • 359 citations

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1990 • 354 citations

Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.

1990 • 350 citations

The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein.

1990 • 347 citations

Thermostable DNA polymerase chain amplification of t(14;18) chromosome breakpoints and detection of minimal residual disease.

1988 • 341 citations

Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults

1984 • 303 citations

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1990 • 290 citations

Detection of minimal disease in hematopoietic malignancies of the B-cell lineage by using third-complementarity-determining region (CDR-III)-specific probes.

1989 • 283 citations

Distribution of t lymphocyte subsets in the human bone marrow and thymus: an analysis with monoclonal antibodies.

1981 • 275 citations

Specific DNA amplification

1988 • 262 citations

Detection of chimeric BCR-ABL genes in acute lymphoblastic leukaemia by the polymerase chain reaction

1991 • 247 citations

The human t(1;19) translocation in pre-B ALL produces multiple nuclear E2A-Pbx1 fusion proteins with differing transforming potentials.

1991 • 237 citations

Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners.

1987 • 236 citations

Analysis of immunoglobulin and T cell receptor genes. Part II: Possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders

1991 • 218 citations

The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias

1991 • 218 citations

Analysis of immunoglobulin and T cell receptor genes. Part I: Basic and technical aspects

1991 • 214 citations

Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.

1990 • 212 citations

Minimal Residual Disease in Childhood B-Lineage Lymphoblastic Leukemia

1990 • 211 citations

Use of polymerase chain reactions to monitor minimal residual disease in acute lymphoblastic leukemia patients

1991 • 210 citations

Detection of minimal residual disease in acute lymphoblastic leukemia by in vitro amplification of rearranged T-cell receptor delta chain sequences

1989 • 200 citations

The Polymerase Chain Reaction

1995 • 200 citations

Results and Significance of Six Randomized Trials in Four Consecutive ALL-BFM Studies

1990 • 188 citations

Human B cell development. I. Phenotypic differences of B lymphocytes in the bone marrow and peripheral lymphoid tissue.

1985 • 188 citations

Prognostic value of S-phase white blood cell count in B-cell chronic lymphocytic leukemia.

1992 • 186 citations

The immunologic detection of minimal residual disease in acute leukemia [published erratum appears in Blood 1990 Nov 1;76(7):1901]

1990 • 186 citations

The cytoplasmic expression of CD3 antigens in normal and malignant cells of the T lymphoid lineage.

1987 • 181 citations

Cellular phenotypes of normal and leukemic hemopoietic cells determined by analysis with selected antibody combinations

1980 • 167 citations

Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia.

1988 • 160 citations

Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias

1990 • 158 citations

Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus.

1988 • 153 citations

POLYMERASE CHAIN REACTION FOR DETECTION OF RESIDUAL LEUKAEMIA

1989 • 152 citations

Review of the incidence and clinical relevance of myeloid antigen-positive acute lymphoblastic leukemia.

1991 • 151 citations

In vitro amplification of T cell gamma gene rearrangements: a new tool for the assessment of minimal residual disease in acute lymphoblastic leukemias.

1989 • 150 citations

Cytoplasmic expression of the CD3 antigen as a diagnostic marker for immature T-cell malignancies

1988 • 147 citations

Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin.

1991 • 140 citations

Diversity and structure of human T cell receptor delta chain genes in peripheral blood gamma/delta-bearing T lymphocytes.

1989 • 137 citations

Human T-cell-receptor delta chain: genomic organization, diversity, and expression in populations of cells.

1988 • 136 citations

Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.

1993 • 134 citations

Two site-specific deletions and t(1;14) translocation restricted to human T-cell acute leukemias disrupt the 5' part of the tal-1 gene.

1991 • 133 citations

Use of oligonucleotide probes directed against T cell antigen receptor gamma delta variable-(diversity)-joining junctional sequences as a general method for detecting minimal residual disease in acute lymphoblastic leukemias.

1990 • 130 citations

RAR-alpha gene rearrangements as a genetic marker for diagnosis and monitoring in acute promyelocytic leukemia

1991 • 115 citations

Gene rearrangements as markers of clonal variation and minimal residual disease in acute lymphoblastic leukemia.

1987 • 111 citations

The effects of postinduction intensification treatment with cytarabine and daunorubicin in adult acute lymphocytic leukemia: a prospective randomized clinical trial by Cancer and Leukemia Group B.

1991 • 110 citations

The (6;9) chromosome translocation, associated with a specific subtype of acute nonlymphocytic leukemia, leads to aberrant transcription of a target gene on 9q34.

1990 • 107 citations

Detection of minimal residual disease in T-cell acute lymphoblastic leukemia using polymerase chain reaction predicts impending relapse

1991 • 106 citations

DETECTION OF RESIDUAL bcr/abl TRANSLOCATION BY POLYMERASE CHAIN REACTION IN CHRONIC MYELOID LEUKAEMIA PATIENTS AFTER BONE-MARROW TRANSPLANTATION

1989 • 106 citations

Improved results of treatment of adult acute lymphoblastic leukemia

1987 • 97 citations

Biologic and prognostic significance of the presence of more than two mu heavy-chain genes in childhood acute lymphoblastic leukemia of B precursor cell origin

1986 • 95 citations

Characterization of immunoglobulin and T-cell receptor gene patterns in B-cell precursor acute lymphoblastic leukemia of childhood.

1990 • 94 citations

Human bone marrow cells positive for terminal deoxynucleotidyl transferase (TdT), HLA-DR, and a T cell marker may represent prothymocytes.

1985 • 92 citations

Circulating Monoclonal B Lymphocytes in Non-Hodgkin's Lymphoma

1984 • 91 citations

Detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin hypervariable region specific oligonucleotide probes

1990 • 89 citations

Shifts in blast cell phenotype and karyotype at relapse of childhood lymphoblastic leukemia [published erratum appears in Blood 1987 Mar;69(3):996]

1986 • 88 citations

Direct sequence analysis of the 14q+ and 18q- chromosome junctions in follicular lymphoma

1990 • 85 citations

Minimal Residual Disease in Acute Leukemia

1984 • 81 citations

High prevalence of T-cell receptor V delta 2-(D)-D delta 3 or D delta 1/2-D delta 3 rearrangements in B-precursor acute lymphoblastic leukemias

1990 • 68 citations

Antibody recognition of the tumor-specific bcr-abl joining region in chronic myeloid leukemia.

1989 • 68 citations

The detection of residual acute lymphoblastic leukemia cells with immunologic methods and polymerase chain reaction: a comparative study.

1990 • 66 citations

High prevalence of T-cell receptor V delta 2-(D)-D delta 3 or D delta 1/2-D delta 3 rearrangements in B-precursor acute lymphoblastic leukemias

1990 • 66 citations

Clinical evaluation of a DNA probe assay for the Philadelphia (Ph1) translocation in chronic myelogenous leukemia.

1988 • 64 citations

The use of DNA probes to monitor minimal residual disease in childhood acute lymphoblastic leukaemia

1989 • 61 citations

Immunophenotyping of leukaemias and non-Hodgkin's lymphomas. Immunological markers and their CD codes.

1988 • 60 citations

Bone marrow transplantation for acute lymphocytic leukemia utilizing total body irradiation followed by high doses of cytosine arabinoside: lack of superiority over cyclophosphamide-containing conditioning regimens.

1990 • 59 citations

Rearrangements of the T cell receptor delta gene in T acute lymphoblastic leukemia cells are distinct from those occurring in B lineage acute lymphoblastic leukemia and preferentially involve one V delta gene segment.

1989 • 57 citations

Rearrangements of the tal-1 locus as clonal markers for T cell acute lymphoblastic leukemia.

1991 • 52 citations

Analysis of junctional diversity in the preferential V delta 1-J delta 1 rearrangement of fresh T-acute lymphoblastic leukemia cells by in vitro gene amplification and direct sequencing

1989 • 50 citations

Terminal deoxynucleotidyl transferase (TdT)-positive cells in cerebrospinal fluid and development of overt CNS leukemia: a 5-year follow-up study in 113 children with a TdT-positive leukemia or non- Hodgkin's lymphoma

1989 • 50 citations

A chromosomal basis of lymphoid malignancy in man

1989 • 46 citations

T-cell receptor delta gene recombination in common acute lymphoblastic leukemia: preferential usage of V delta 2 and frequent involvement of the J alpha cluster

1991 • 45 citations

Detection of Minimal Residual Acute Lymphoblastic Leukemia by Immunological Marker Analysis: Possibilities and Limitations

1986 • 45 citations

Acute Lymphoblastic Leukemia: Current Status of Therapy in Children

1984 • 44 citations

Chromosomes and causation of human cancer and leukemia: XXVIII. Value of detailed chromosome studies on large numbers of cells in CML

1977 • 38 citations

Dutch Childhood Leukemia Study Group: Early Results of Study ALL VI (1984–1988)

1990 • 35 citations

T-cell receptor delta gene recombination in common acute lymphoblastic leukemia: preferential usage of V delta 2 and frequent involvement of the J alpha cluster

1991 • 35 citations

Terminal deoxynucleotidyl transferase positive subpopulations occur in the majority of ANLL: implications for the detection of minimal disease.

1990 • 34 citations

Phenotypic heterogeneity of TDT+ cells in the blood and bone marrow: implications for surveillance of residual leukemia [see comments]

1989 • 31 citations

Detection of Minimal Residual Disease in TdT Positive T Cell Malignancies by Double Immunofluorescence Staining

1984 • 29 citations

Growth requirements for human acute lymphoblastic leukemia cells: refinement of a clonogenic assay.

1988 • 29 citations

An improved clonal excess assay using flow cytometry and B-cell gating

1990 • 29 citations

Detection of residual disease in acute leukemia using immunological markers

1988 • 23 citations

Immunophenotypic characteristics of cerebrospinal fluid cells in children with acute lymphoblastic leukemia at diagnosis

1990 • 23 citations

Evaluation of Cerebrospinal Fluid Mononuclear Cells Obtained from Children with Acute Lymphocytic Leukemia: Advantages of Combining Cytomorphology and Terminal Deoxynucleotidyl Transferase

1983 • 23 citations

Immunologic Approaches to the Classification and Management of Lymphomas and Leukemias

1988 • 21 citations

Double Marker Analysis for Terminal Deoxynucleotidyl Transferase and Myeloid Antigens in Acute Nonlymphocytic Leukemia Patients and Healthy Subjects

1990 • 18 citations

Detection of minimal residual disease in leukemic patients with the t(10;14)(q24;q11) chromosomal translocation.

1990 • 18 citations

The human T-cell rearranging gamma (TRG) genes and the gamma T-cell receptors

1988 • 18 citations

Genetic and cytogenetic changes in acute lymphoblastic leukemia

1988 • 17 citations

A common Vδ₂—Dδ₂—Dδ₃ T cell receptor gene rearrangement in precursor B acute lymphoblastic leukaemia

1991 • 16 citations

Detection of Minimal Residual Leukemia by Polymerase Chain Reactions

1993 • 10 citations

Early diagnosis of smoldering acute lymphoblastic leukemia using immunological marker analysis.

1993 • 8 citations

Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia Patients by Polymerase Chain Reactions

1992 • 5 citations

Differences in Immunoglobulin and T-Cell Receptor Gene Rearrangement Patterns in Acute Lymphoblastic Leukemia Between Diagnosis and Relapse

1994 • 2 citations