CD22: A Multifunctional Receptor That Regulates B Lymphocyte Survival and Signal Transduction

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

2000 • 2,694 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

Mice Transgenic for Baff Develop Lymphocytic Disorders along with Autoimmune Manifestations

1999 • 1,464 citations

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

2002 • 1,442 citations

TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease

2000 • 1,171 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Treatment of Rheumatoid Arthritis by Selective Inhibition of T-Cell Activation with Fusion Protein CTLA4Ig

2003 • 1,060 citations

Marginal Zone and B1 B Cells Unite in the Early Response against T-Independent Blood-Borne Particulate Antigens

2001 • 955 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Marginal-zone B cells

2002 • 850 citations

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren’s syndrome

2002 • 816 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Baff Mediates Survival of Peripheral Immature B Lymphocytes

2000 • 705 citations

A Novel Mouse with B Cells but Lacking Serum Antibody Reveals an Antibody-independent Role for B Cells in Murine Lupus

1999 • 694 citations

Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren’s syndrome

2002 • 679 citations

Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways.

1994 • 664 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

The Innate Mononuclear Phagocyte Network Depletes B Lymphocytes through Fc Receptor–dependent Mechanisms during Anti-CD20 Antibody Immunotherapy

2004 • 632 citations

TACI-Ig Neutralizes Molecules Critical for B Cell Development and Autoimmune Disease

2001 • 611 citations

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1993 • 578 citations

An open study of B lymphocyte depletion in systemic lupus erythematosus

2002 • 573 citations

Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura

2001 • 553 citations

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

1995 • 551 citations

Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule

1995 • 546 citations

Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response

2000 • 537 citations

Hyperresponsive B Cells in CD22-Deficient Mice

1996 • 530 citations

Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes

2001 • 523 citations

Efficacy of the Anti-CD22 Recombinant Immunotoxin BL22 in Chemotherapy-Resistant Hairy-Cell Leukemia

2001 • 514 citations

Systemic Lupus Erythematosus

2020 • 514 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

Polygenic control of susceptibility to murine systemic lupus erythematosus

1994 • 484 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

1996 • 437 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Estrogen alters thresholds for B cell apoptosis and activation

2002 • 431 citations

CD22 is a negative regulator of B-cell receptor signalling

1997 • 427 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily

1994 • 406 citations

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21 ^CIP1/WAF1 and cyclin D proteins

1998 • 401 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

1998 • 397 citations

CD22 regulates thymus-independent responses and the lifespan of B cells

1996 • 395 citations

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

1995 • 394 citations

B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40

1993 • 390 citations

Estrogen alters thresholds for B cell apoptosis and activation

2002 • 387 citations

B‐cell subsets and the mature ­preimmune repertoire. Marginal zone and B1 B cells as part of a “natural immune memory”

2000 • 380 citations

The CD19–CD21 Complex Regulates Signal Transduction Thresholds Governing Humoral Immunity and Autoimmunity

1997 • 379 citations

A Critical Role for Complement in Maintenance of Self-Tolerance

1998 • 373 citations

Lupus susceptibility loci in New Zealand mice.

1994 • 359 citations

The role of B cells in lpr/lpr-induced autoimmunity.

1994 • 356 citations

Immune regulation by the ST6Gal sialyltransferase

1998 • 352 citations

The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells

1991 • 348 citations

Clinical outcome in 22 patients with rheumatoid arthritis treated with B lymphocyte depletion

2002 • 345 citations

Antibody-targeted chemotherapy with CMC-544: a CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies

2003 • 336 citations

Deficiency in CD22, a B Cell–specific Inhibitory Receptor, Is Sufficient to Predispose to Development of High Affinity Autoantibodies

1999 • 321 citations

Quantitative Genetic Variation in CD19 Expression Correlates with Autoimmunity

2000 • 314 citations

CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING^*

1997 • 296 citations

Cutting Edge: Expansion and Activation of A Population of Autoreactive Marginal Zone B Cells in a Model of Estrogen-Induced Lupus

2001 • 290 citations

Phase I immunotoxin trial in patients with B-cell lymphoma.

1991 • 289 citations

The central and multiple roles of B cells in lupus pathogenesis

1999 • 286 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains.

1994 • 268 citations

CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity.

1996 • 263 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia

1985 • 259 citations

Efficacy of selective B cell blockade in the treatment of rheumatoid arthritis: Evidence for a pathogenetic role of B cells

2002 • 255 citations

Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies.

1989 • 255 citations

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement.

1994 • 250 citations

Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes

1998 • 249 citations

CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation.

1994 • 245 citations

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice.

1993 • 243 citations

CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.

1993 • 243 citations

Down-regulation of p27 by Two Mechanisms, Ubiquitin-mediated Degradation and Proteolytic Processing

1999 • 231 citations

Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2

1996 • 223 citations

Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition.

1993 • 222 citations

A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy

1993 • 221 citations

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

2002 • 220 citations

Cr2, a Candidate Gene in the Murine Sle1c Lupus Susceptibility Locus, Encodes a Dysfunctional Protein

2001 • 213 citations

The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling

1998 • 212 citations

CD19 Regulates Src Family Protein Tyrosine Kinase Activation in B Lymphocytes through Processive Amplification

2000 • 211 citations

The Peritoneal Cavity Provides a Protective Niche for B1 and Conventional B Lymphocytes during Anti-CD20 Immunotherapy in Mice

2005 • 209 citations

A Double-Edged Kinase Lyn: A Positive and Negative Regulator for Antigen Receptor–mediated Signals

1998 • 206 citations

The monoclonal antibodies alpha S-HCL 1 (alpha Leu-14) and alpha S-HCL 3 (alpha Leu-M5) allow the diagnosis of hairy cell leukemia

1985 • 203 citations

CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation.

1996 • 200 citations

CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

2002 • 195 citations

Tyrosine Phosphorylation of the vav Proto-Oncogene Product in Activated B Cells

1992 • 195 citations

Tuning Antigen Receptor Signaling by CD22: Integrating Cues from Antigens and the Microenvironment

1997 • 195 citations

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

2000 • 194 citations

CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes

1997 • 193 citations

Phosphatidylinositol 3-kinase-γ activates Bruton’s tyrosine kinase in concert with Src family kinases

1997 • 192 citations

The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion

1990 • 192 citations

CD22 associates with the human surface IgM-B-cell antigen receptor complex.

1993 • 185 citations

A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy

1993 • 185 citations

Positive and negative regulation of Src-family membrane kinases by CD45

1999 • 184 citations

The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound

2002 • 180 citations

Epratuzumab, a humanized monoclonal antibody targeting CD22: characterization of in vitro properties.

2003 • 179 citations

The BAFF/APRIL System: An Important Player in Systemic Rheumatic Diseases

2004 • 178 citations

Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes

1998 • 175 citations

The Emerging Field of Receptor-Mediated Inhibitory Signaling: SHP or SHIP?

1996 • 174 citations

The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.

1993 • 173 citations

Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP.

1996 • 173 citations

HD39 (B3), a B lineage-restricted antigen whose cell surface expression is limited to resting and activated human B lymphocytes.

1986 • 173 citations

Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3-Kinase Activation, Inositol-1,4,5-Trisphosphate Production and Ca2+ Mobilization

1997 • 172 citations

A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor

2002 • 171 citations

Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact

2004 • 170 citations

Cutting Edge: A Role for CD1 in the Pathogenesis of Lupus in NZB/NZW Mice

2000 • 169 citations

B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein.

1994 • 169 citations

Evidence for selection of a population of multi-reactive B cells into the splenic marginal zone

1997 • 167 citations

Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E

1999 • 165 citations

Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study

1995 • 165 citations

Retention of B-cell-specific monoclonal antibodies by human lymphoma cells

1994 • 163 citations

The effect of anti‐CD40 ligand antibody on B cells in human systemic lupus erythematosus

2002 • 161 citations

CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms

2004 • 160 citations

Association of CD22 with the B cell antigen receptor

1993 • 157 citations

The oligosaccharide binding specificities of CD22 beta, a sialic acid-specific lectin of B cells.

1994 • 153 citations

Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells.

1988 • 152 citations

cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions.

1991 • 152 citations

CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.

1997 • 148 citations

Complement Receptors CD21/35 Link Innate and Protective Immunity during Streptococcus pneumoniae Infection by Regulating IgG3 Antibody Responses

2002 • 148 citations

Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors.

1994 • 147 citations

Phase I clinical trial of a monoclonal antibody against CD40-ligand (IDEC-131) in patients with systemic lupus erythematosus.

2001 • 147 citations

A pilot study of the anti-CD20 monoclonal antibody rituximab in patients with refractory immune thrombocytopenia.

2000 • 144 citations

Localization of the Putative Sialic Acid-binding Site on the Immunoglobulin Superfamily Cell-surface Molecule CD22

1996 • 143 citations

ANTINUCLEAR ANTIBODY IN SYSTEMIC SCLEROSIS (SCLERODERMA)

1996 • 141 citations

Reduction of marginal zone B cells in CD22-deficient mice

2002 • 140 citations

Tyrosine Phosphorylation of CD22 During B Cell Activation

1992 • 139 citations

Modulation of B Lymphocyte Antigen Receptor Signal Transduction by a CD19/CD22 Regulatory Loop

1999 • 138 citations

Binding of Human Plasma Sialoglycoproteins by the B Cell-specific Lectin CD22

1995 • 136 citations

Phosphorylation of CD19 Y484 and Y515, and Linked Activation of Phosphatidylinositol 3-Kinase, Are Required for B Cell Antigen Receptor-Mediated Activation of Bruton’s Tyrosine Kinase

1999 • 126 citations

FcγRIIB1 Inhibition of BCR-Mediated Phosphoinositide Hydrolysis and Ca2+ Mobilization Is Integrated by CD19 Dephosphorylation

1997 • 121 citations

CD22 Forms a Quaternary Complex with SHIP, Grb2, and Shc

2000 • 121 citations

CD19 Amplifies B Lymphocyte Signal Transduction by Regulating Src-Family Protein Tyrosine Kinase Activation

1999 • 120 citations

Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restriction

1990 • 120 citations

Phosphotyrosine‐dependent association between CD22 and protein tyrosine phosphatase 1C

1995 • 120 citations

Pharmacokinetics, dosimetry, and initial therapeutic results with 131I- and (111)In-/90Y-labeled humanized LL2 anti-CD22 monoclonal antibody in patients with relapsed, refractory non-Hodgkin's lymphoma.

1999 • 120 citations

Systemic Lupus Erythematosus

2005 • 117 citations

Constitutive endocytosis and degradation of CD22 by human B cells.

1995 • 116 citations

Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy.

1988 • 116 citations

Identification of CD22 Ligands on Bone Marrow Sinusoidal Endothelium Implicated in CD22-dependent Homing of Recirculating B Cells

1999 • 115 citations

Recombinant RFB4 Immunotoxins Exhibit Potent Cytotoxic Activity for CD22-Bearing Cells and Tumors

1997 • 115 citations

The HB-6, CDw75, and CD76 differentiation antigens are unique cell-surface carbohydrate determinants generated by the beta-galactoside alpha 2,6-sialyltransferase.

1992 • 112 citations

Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand.

1995 • 112 citations

Interaction of CD22 with α2,6-linked sialoglycoconjugates: innate recognition of self to dampen B cell autoreactivity?

2002 • 111 citations

CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling

1997 • 111 citations

CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor

1998 • 106 citations

Counterregulation by the Coreceptors CD19 and CD22 of MAP Kinase Activation by Membrane Immunoglobulin

1997 • 106 citations

Immunotherapy of Non-Hodgkin's Lymphomas

2001 • 105 citations

Views on Vav

1997 • 103 citations

Role of the CD22 human B cell antigen in B cell triggering by anti-immunoglobulin.

1988 • 102 citations

CD19 regulates B lymphocyte responses to transmembrane signals

1998 • 100 citations

B cell antigen receptor-mediated apoptosis. Importance of accessory molecules CD19 and CD22, and of surface IgM cross-linking.

1995 • 100 citations

Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule.

1992 • 99 citations

Sialic Acid Binding Domains of CD22 Are Required For Negative Regulation of B Cell Receptor Signaling

2002 • 99 citations

The antitumor activity of an anti-CD22 immunotoxin in SCID mice with disseminated Daudi lymphoma is enhanced by either an anti-CD19 antibody or an anti-CD19 immunotoxin

1992 • 98 citations

Amplification of human B cell activation by a monoclonal antibody to the B cell-specific antigen CD22, Bp 130/140.

1987 • 98 citations

Immunoregulatory Role of CD1d in the Hydrocarbon Oil-Induced Model of Lupus Nephritis

2003 • 98 citations

Activated B Cells Express Increased Levels of Costimulatory Molecules in Young Autoimmune NZB and (NZB × NZW)F1 Mice

2000 • 97 citations

CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity

2004 • 97 citations

Molecular interactions regulate BCR signal inhibition by CD22 and CD72

2004 • 96 citations

CD19, CD21, and CD22: Multifaceted Response Regulators of B Lymphocyte Signal Transduction

2001 • 95 citations

Positive and negative roles of the tyrosine kinase Lyn in B cell function

1998 • 94 citations

CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling.

1992 • 90 citations

Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest

1994 • 90 citations

Activation-induced Association of a 145-kDa Tyrosine-phosphorylated Protein with Shc and Syk in B Lymphocytes and Macrophages

1996 • 88 citations

Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells.

1995 • 87 citations

Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys

1999 • 87 citations

Linkage of a major quantitative trait locus toYaa gene-induced lupus-like nephritis in (NZW × C57BL/6)F1 mice

1998 • 85 citations

Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22

2004 • 85 citations

Cd22aPRE-mRNA Dysregulated Expression of theCd22Gene as a Result of a Short Interspersed Nucleotide Element Insertion inCd22aLupus-Prone Mice

2000 • 84 citations

Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation

1996 • 83 citations

Involvement of p72syk kinase, p53/561yn kinase and phosphatidyl inositol‐3 kinase in signal transduction via the human B lymphocyte antigen CD22

1996 • 82 citations

CD22 Cross-Linking Generates B-Cell Antigen Receptor-Independent Signals That Activate the JNK/SAPK Signaling Cascade

1999 • 82 citations

Internalization and intracellular processing of an anti B‐cell lymphoma monoclonal antibody, ll2

1994 • 79 citations

Definition of the Sites of Interaction between the Protein Tyrosine Phosphatase SHP-1 and CD22

1999 • 79 citations

Epitope specificity of the anti-(B cell lymphoma) monoclonal antibody, LL2

1993 • 78 citations

Immunotherapy of non-Hodgkin's lymphoma with hLL2 (epratuzumab, an anti-CD22 monoclonal antibody) and Hu1D10 (apolizumab)

2002 • 76 citations

Role of the inositol phosphatase SHIP in B cell receptor-induced Ca2+ oscillatory response.

1998 • 75 citations

Constitutive membrane association potentiates activation of Bruton tyrosine kinase

1997 • 73 citations

A selective defect in IgM antigen receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes.

1994 • 73 citations

Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis

2004 • 73 citations

Co-receptors of B lymphocytes

1997 • 73 citations

The antitumor activity of an anti-CD22 immunotoxin in SCID mice with disseminated Daudi lymphoma is enhanced by either an anti-CD19 antibody or an anti-CD19 immunotoxin

1992 • 72 citations

Differential expression of CD22 (Lyb8) on murine B cells

1996 • 72 citations

Evaluation of four CD22 antibodies as ricin a chain‐containing immunotoxins for the in vivo therapy of human B‐cell leukemias and lymphomas

1988 • 71 citations

Hematopoietic Cell Phosphatase Is Recruited to CD22 following B Cell Antigen Receptor Ligation

1995 • 69 citations

Cutting Edge: Role of the Inositol Phosphatase SHIP in B Cell Receptor-Induced Ca2+ Oscillatory Response

1998 • 66 citations

Analysis of Tyrosine Phosphorylation-dependent Interactions between Stimulatory Effector Proteins and the B Cell Co-receptor CD22

1999 • 66 citations

Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest

1994 • 65 citations

Constitutively unmasked CD22 on B cells of ST6Gal I knockout mice: novel sialoside probe for murine CD22

2002 • 64 citations

The Src Homology Domain 2-Containing Inositol Phosphatase SHIP Forms a Ternary Complex with Shc and Grb2 in Antigen Receptor-stimulated B Lymphocytes

1999 • 64 citations

Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins

2003 • 63 citations

CD19 Can Regulate B Lymphocyte Signal Transduction Independent of Complement Activation

2001 • 62 citations

Remission of inflammatory arthropathy in association with anti-CD20 therapy for non-Hodgkin's lymphoma

1999 • 59 citations

The mouse mutant "motheaten." II. Functional studies of the immune system.

1978 • 56 citations

Altered selection processes of B lymphocytes in autoimmune NZB/W mice, despite intact central tolerance against DNA

2001 • 56 citations

Genomic structure and chromosomal mapping of the human CD22 gene.

1993 • 56 citations

The CD19-CD21 Signal Transduction Complex of B Lymphocytes Regulates the Balance between Health and Autoimmune Disease: Systemic Sclerosis as a Model System

2004 • 56 citations

Expression and structure of CD22 in acute leukemia

1988 • 54 citations

A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: implications for B‐cell homing to the bone marrow

2000 • 51 citations

CD40 and its ligand: Central players in B lymphocyte survival, growth, and differentiation

1995 • 51 citations

Ly-6 Superfamily Members Ly-6A/E, Ly-6C, and Ly-6I Recognize Two Potential Ligands Expressed by B Lymphocytes

2002 • 48 citations

Organization of the murine Cd22 locus. Mapping to chromosome 7 and characterization of two alleles.

1993 • 48 citations

B lymphocytes contribute to autoimmune disease pathogenesis: current trends and clinical implications

2003 • 48 citations

B cell antigen receptor-evoked calcium influx is enhanced in CD22-deficient B cell lines.

1997 • 47 citations

Epratuzumab: targeting B-cell malignancies through CD22.

2003 • 47 citations

The SH2 Domain Containing Tyrosine Phosphatase-1 Down-regulates Activation of Lyn and Lyn-induced Tyrosine Phosphorylation of the CD19 Receptor in B Cells

2001 • 47 citations

Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of90Y-DOTA-peptide-Lym-1 in lymphoma xenografts

2003 • 46 citations

Introduction: Response-regulators of B lymphocyte signaling thresholds provide a context for antigen receptor signal transduction

1998 • 46 citations

CD19 Amplification of B Lymphocyte Ca2+ Responses

2001 • 45 citations

Delivery of saporin to human B-cell lymphoma using bispecific antibody: targeting via CD22 but not CD19, CD37, or immunoglobulin results in efficient killing.

1993 • 44 citations

Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody

1982 • 43 citations

Co‐receptor and accessory regulation of B‐cell antigen receptor signal transduction

1997 • 41 citations

Evaluation of immunotoxins containing single‐chain ribosome‐inactivating proteins and an anti‐CD22 monoclonal antibody (OM124):in vitroandin vivostudies

1998 • 37 citations

Thyroid-Infiltrating B Lymphocytes in Graves' Disease are Related to Marginal Zone and Memory B Cell Compartments

2001 • 37 citations

Response of B-cell lymphoma to a combination of bispecific antibodies and saporin

1996 • 35 citations

Severely Impaired B Lymphocyte Proliferation, Survival, and Induction of the c-Myc:Cullin 1 Ubiquitin Ligase Pathway Resulting from CD22 Deficiency on the C57BL/6 Genetic Background

2004 • 35 citations

The Mouse Mutant “Motheaten”

1978 • 34 citations

Recombinant RFB4 single-chain immunotoxin that is cytotoxic towards CD22-positive cells

1997 • 33 citations

Initial experience in treating human lymphoma with a combination of bispecific antibody and saporin.

1992 • 33 citations

Selective internalization of monoclonal antibodies by B‐cell chronic lymphocytic leukaemia cells

2003 • 33 citations

Delivery of the ribosome-inactivating protein, gelonin, to lymphoma cells via CD22 and CD38 using bispecific antibodies

1995 • 33 citations

Treatment of B-cell lymphomas with combination of bispecific antibodies and saporin

1995 • 32 citations

CD22 antigen: biosynthesis, glycosyiation and surface expression of a B lymphocyte protein involved in B cell activation and adhesion

1991 • 32 citations

CD22-directed monoclonal antibody therapy for lymphoma

2003 • 31 citations

Polymorphisms in the Cd22 gene of inbred mouse strains

1999 • 28 citations

CD19 and CD22 Regulate a B Lymphocyte Signal Transduction Pathway That Contributes to Autoimmunity.

2000 • 28 citations

Structural characterization of the human B lymphocyte-restricted differentiation antigen CD22. Comparison with CD21 (complement receptor type 2/Epstein-Barr virus receptor).

1988 • 26 citations

Differential expression of the B cell-restricted molecule CD22 on neonatal B lymphocytes depending upon antigen stimulation

2000 • 22 citations

Highly potent CD22-recombinant ricin A results in complete cure of disseminated malignant B-cell xenografts in SCID mice but fails to cure solid xenografts in nude mice

1996 • 20 citations

B cells and autoantibodies in the pathogenesis of lupus nephritis

1998 • 11 citations