Views on Vav

Proteins regulating Ras and its relatives

1993 • 1,930 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

Cooperative interaction of S. pombe proteins required for mating and morphogenesis

1994 • 303 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

A Functional T-Cell Receptor Signaling Pathway Is Required for p95^vav Activity

1995 • 173 citations

Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon Activation of mature T lymphocytes

1995 • 162 citations

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

1996 • 152 citations

Does Vav bind to F‐actin through a CH domain?

1995 • 145 citations

Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL.

1995 • 145 citations

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.

1996 • 143 citations

The protein tyrosine kinase ZAP-70 can associate with the SH2 domain of proto-Vav.

1994 • 140 citations

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.

1994 • 134 citations

Interaction of Vav with ENX-1, a Putative Transcriptional Regulator of Homeobox Gene Expression

1996 • 129 citations

The Tyrosine Phosphatase PTP1C Associates with Vav, Grb2, and mSos1 in Hematopoietic Cells

1996 • 124 citations

Vav Is Necessary for Prolactin-stimulated Proliferation and Is Translocated into the Nucleus of a T-cell Line

1995 • 111 citations

The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

1995 • 111 citations

The T-cell antigen receptor utilizes Lck, Raf-1, and MEK-1 for activating mitogen-activated protein kinase. Evidence for the existence of a second protein kinase C-dependent pathway in an Lck-negative Jurkat cell mutant.

1994 • 109 citations

Novel signaling pathway suggested by SH3 domain-mediated p95vav/heterogeneous ribonucleoprotein K interaction.

1994 • 94 citations

Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor.

1994 • 90 citations

Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.

1995 • 90 citations

SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin.

1996 • 80 citations

Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1

1995 • 80 citations

p95^vavAssociates with the Nuclear Protein Ku-70

1996 • 79 citations

Activation of Ras in vitro and in intact fibroblasts by the Vav guanine nucleotide exchange protein.

1994 • 78 citations

Thrombin Receptor Activation and Integrin Engagement Stimulate Tyrosine Phosphorylation of the Proto-oncogene Product, p95vav, in Platelets

1996 • 74 citations

Interactions between the Protein-tyrosine Kinase ZAP-70, the Proto-oncoprotein Vav, and Tubulin in Jurkat T Cells

1995 • 71 citations

Vav binds to several SH2/SH3 containing proteins in activated lymphocytes.

1994 • 65 citations

Inhibition of hematopoietic development from embryonic stem cells by antisense vav RNA.

1993 • 60 citations

The proline-rich region of Vav binds to Grb2 and Grb3-3.

1995 • 49 citations

Single point mutations in the SH2 domain impair the transforming potential of vav and fail to activate proto-vav.

1993 • 42 citations

Vav: Function and Regulation in Hematopoietic Cell Signaling

1996 • 36 citations

A functional analysis of protooncogene Vav's role in adult human hematopoiesis

1996 • 26 citations

Deleted Work

1955 • 0 citations