Highly potent CD22-recombinant ricin A results in complete cure of disseminated malignant B-cell xenografts in SCID mice but fails to cure solid xenografts in nude mice

Determination of subcutaneous tumor size in athymic (nude) mice

1989 • 1,668 citations

Tables for Convenient Calculation of Median-Effective Dose (LD 50 or ED 50 ) and Instructions in Their Use

1952 • 1,061 citations

Ricin: structure, mode of action, and some current applications

1994 • 469 citations

The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA.

1988 • 380 citations

Phase I immunotoxin trial in patients with B-cell lymphoma.

1991 • 289 citations

A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy

1993 • 221 citations

New coupling agents for the synthesis of immunotoxins containing a hindered disulfide bond with improved stability in vivo.

1987 • 205 citations

A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy

1993 • 185 citations

Continuous infusion of the anti-CD22 immunotoxin IgG-RFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study

1995 • 165 citations

Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy.

1988 • 116 citations

Ricin A-Chain and Ricin A-Chain Immunotoxins Rapidly Damage Human Endothelial Cells: Implications for Vascular Leak Syndrome

1993 • 106 citations

The antitumor activity of an anti-CD22 immunotoxin in SCID mice with disseminated Daudi lymphoma is enhanced by either an anti-CD19 antibody or an anti-CD19 immunotoxin

1992 • 98 citations

Disseminated or localized growth of a human B‐cell tumor (Daudi) in scid mice

1990 • 95 citations

Antitumor activity of Fab' and IgG-anti-CD22 immunotoxins in disseminated human B lymphoma grown in mice with severe combined immunodeficiency disease: effect on tumor cells in extranodal sites.

1991 • 94 citations

Molecular mechanisms regulating CD19, CD20 and CD22 gene expression

1994 • 79 citations

Internalization and intracellular processing of an anti B‐cell lymphoma monoclonal antibody, ll2

1994 • 79 citations

The antitumor activity of an anti-CD22 immunotoxin in SCID mice with disseminated Daudi lymphoma is enhanced by either an anti-CD19 antibody or an anti-CD19 immunotoxin

1992 • 72 citations

Evaluation of four CD22 antibodies as ricin a chain‐containing immunotoxins for the in vivo therapy of human B‐cell leukemias and lymphomas

1988 • 71 citations

Pseudomonas exotoxin-based immunotoxins containing the antibody LL2 or LL2-Fab' induce regression of subcutaneous human B-cell lymphoma in mice.

1993 • 69 citations

Pharmacokinetics of tumor-reactive immunotoxins in tumor-bearing mice: effect of antibody valency and deglycosylation of the ricin A chain on clearance and tumor localization.

1988 • 65 citations

Relationship between internalization and cytotoxicity of ricin A‐chain immunotoxins

1988 • 58 citations

Recent developments in immunotoxin therapy

1994 • 48 citations

Eradication of minimal disease in severe combined immunodeficient mice with disseminated Daudi lymphoma using chemotherapy and an immunotoxin cocktail

1994 • 39 citations

Comparison of the pharmacokinetics and hepatotoxic effects of saporin and ricin A-chain immunotoxins on murine liver parenchymal cells.

1988 • 37 citations

Eradication of minimal disease in severe combined immunodeficient mice with disseminated Daudi lymphoma using chemotherapy and an immunotoxin cocktail

1994 • 29 citations

Pharmacokinetic considerations on monoclonal antibodies.

1989 • 27 citations

Cytotoxic Potency of CD22‐Ricin A Depends on Intracellular Routing Rather than on the Number of Internalized Molecules

1995 • 15 citations

Pharmacokinetic studies in mice with ICI D0490, a novel recombinant ricin A-chain immunotoxin

1993 • 9 citations

Rationale for the Clinical use of Immunotoxins: Monoclonal Antibodies Conjugated to Ribosome-Inactivating Proteins

1993 • 8 citations

A quantitative flow cytometric method for the determination of immunotoxin-induced cell kill in marrow grafts.

1994 • 1 citations