ANTINUCLEAR ANTIBODY IN SYSTEMIC SCLEROSIS (SCLERODERMA)

ARTHRITIS AND ALLIED CONDITIONS

1949 • 1,599 citations

Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology

1989 • 1,543 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

RNA POLYMERASE II

1991 • 729 citations

Autoantibody to centromere (kinetochore) in scleroderma sera.

1980 • 721 citations

A human centromere antigen (CENP-B) interacts with a short specific sequence in alphoid DNA, a human centromeric satellite.

1989 • 659 citations

Clinical correlations and prognosis based on serum autoantibodies in patients with systemic sclerosis

1988 • 568 citations

Diversity of antinuclear antibodies in progressive systemic sclerosis

1980 • 520 citations

Eukaryotic RNA Polymerase

1985 • 500 citations

Fibrillarin: a new protein of the nucleolus identified by autoimmune sera

1985 • 488 citations

The U3 small nucleolar ribonucleoprotein functions in the first step of preribosomal RNA processing

1990 • 449 citations

Molecular cloning of cDNA for CENP-B, the major human centromere autoantigen

1987 • 420 citations

Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone.

1991 • 403 citations

Arthritis and Allied Conditions

1993 • 392 citations

The CREST syndrome: A distinct serologic entity with anticentromere antibodies

1980 • 369 citations

CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate

1992 • 340 citations

High Titers of Autoantibodies to Topoisomerase I (Scl-70) in Sera from Scleroderma Patients

1986 • 307 citations

Purification and partial characterization of a nucleolar scleroderma antigen (Mr = 34,000; pI, 8.5) rich in NG,NG-dimethylarginine.

1985 • 282 citations

Clinical and Prognostic Associations Based on Serum Antinuclear Antibodies in Japanese Patients with Systemic Sclerosis

1994 • 281 citations

Identification of a nuclear protein (Scl-70) as a unique target of human antinuclear antibodies in scleroderma.

1979 • 279 citations

cDNA cloning of human DNA topoisomerase I: catalytic activity of a 67.7-kDa carboxyl-terminal fragment.

1988 • 260 citations

Identification and functional analysis of two U3 binding sites on yeast pre-ribosomal RNA.

1992 • 257 citations

Monoclonal autoantibody from a (new zealand black x new zealand white)F₁ mouse and some human scleroderma sera target an MT_r 34,000 nucleolar protein of the U3 RNP particle

1987 • 252 citations

Autoantibody to RNA polymerase I in scleroderma sera.

1987 • 241 citations

CENP-B: a major human centromere protein located beneath the kinetochore.

1990 • 238 citations

B cells process and present lupus autoantigens that initiate autoimmune T cell responses.

1994 • 236 citations

Clinical and laboratory associations of anticentromere antibody in patients with progressive systemic sclerosis

1984 • 232 citations

Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II

1989 • 228 citations

Clinical associations of anticentromere antibodies and antibodies to topoisomerase i. a study of 355 patients

1988 • 223 citations

How some T cells escape tolerance induction

1989 • 216 citations

Correlates between autoantibodies to nucleolar antigens and clinical features in patients with systemic sclerosis (scleroderma)

1988 • 213 citations

Serum autoantibody to the nucleolar antigen PM‐Scl. Clinical and immunogenetic associations

1992 • 208 citations

Three human chromosomal autoantigens are recognized by sera from patients with anti-centromere antibodies.

1986 • 206 citations

Autoantibody Reactive with RNA Polymerase III in Systemic Sclerosis

1993 • 204 citations

Antinuclear antibody with distinct specificity for polymyositis.

1977 • 198 citations

Different antibody patterns and different prognoses in patients with scleroderma with various extent of skin sclerosis.

1986 • 196 citations

Structural analysis of the human U3 ribonucleoprotein particle reveal a conserved sequence available for base pairing with pre-rRNA.

1987 • 190 citations

Antibodies to a nuclear/nucleolar antigen in patients with polymyositis overlap syndromes

1984 • 184 citations

Autoantibody to U3 Nucleolar Ribonucleoprotein (Fibrillarin) In Patients with Systemic Sclerosis

1992 • 180 citations

Detection of a nucleolar 7-2 ribonucleoprotein and a cytoplasmic 8-2 ribonucleoprotein with autoantibodies from patients with scleroderma.

1983 • 177 citations

Serological markers in progressive systemic sclerosis: clinical correlations.

1983 • 176 citations

Breaking T cell tolerance with foreign and self co-immunogens. A study of autoimmune B and T cell epitopes of cytochrome c.

1992 • 175 citations

Autoantibodies to fibrillarin in systemic sclerosis (scleroderma). An immunogenetic, serologic, and clinical analysis

1996 • 167 citations

cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera.

1991 • 167 citations

Anticentromere antibody as a predictor of digital ischemic loss in patients with systemic sclerosis

1992 • 161 citations

The Clinical and Immunogenetic Features of Patients with Autoantibodies to the Nucleolar Antigen PM-Scl

1992 • 157 citations

Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast.

1991 • 157 citations

An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs.

1991 • 157 citations

Prognostic significance of anticentromere antibodies and anti–topoisomerase i antibodies in Raynaud's disease. A prospective study

1991 • 155 citations

Autoantibody reactive with three classes of RNA polymerases in sera from patients with systemic sclerosis.

1993 • 154 citations

The RNA Processing Enzyme RNase MRP Is Identical to the Th RNP and Related to RNase P

1989 • 152 citations

Distribution of kinetochore (centromere) antigen in mammalian cell nuclei.

1981 • 147 citations

The purification and characterization of DNA topoisomerases I and II of the yeast Saccharomyces cerevisiae.

1984 • 146 citations

Immunogenetic associations of scleroderma‐related antinuclear antibodies

1990 • 145 citations

Association of amino acid sequences in the HLA-DQB1 first domain with antitopoisomerase I autoantibody response in scleroderma (progressive systemic sclerosis).

1992 • 135 citations

Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I

1986 • 133 citations

Determination of an epitope of the diffuse systemic sclerosis marker antigen DNA topoisomerase I: sequence similarity with retroviral p30gag protein suggests a possible cause for autoimmunity in systemic sclerosis.

1989 • 132 citations

Immunogenetic prediction of pulmonary fibrosis in systemic sclerosis

1991 • 132 citations

Anticentromere antibody in primary biliary cirrhosis.

1982 • 128 citations

Molecular cloning of Xenopus fibrillarin, a conserved U3 small nuclear ribonucleoprotein recognized by antisera from humans with autoimmune disease.

1990 • 127 citations

The centromere specific histone CENP-A is selectively retained in discrete foci in mammalian sperm nuclei

1990 • 126 citations

Racial differences in the distribution of systemic sclerosis–related serum antinuclear antibodies

1994 • 124 citations

Immunolocalization and partial characterization of a nucleolar autoantigen (PM-Scl) associated with polymyositis/scleroderma overlap syndromes.

1986 • 124 citations

Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles.

1982 • 122 citations

Molecular characterization of an autoantigen of PM-Scl in the polymyositis/scleroderma overlap syndrome: a unique and complete human cDNA encoding an apparent 75-kD acidic protein of the nucleolar complex.

1991 • 119 citations

Sequential association of nucleolar 7-2 RNA with two different autoantigens.

1983 • 117 citations

Initiation of autoimmunity to the p53 tumor suppressor protein by complexes of p53 and SV40 large T antigen.

1994 • 116 citations

Mercuric chloride induces autoantibodies against U3 small nuclear ribonucleoprotein in susceptible mice.

1989 • 114 citations

Immunolocalization of 7-2-ribonucleoprotein in the granular component of the nucleolus

1988 • 111 citations

Antinuclear antibodies in patients with Raynaud's phenomenon: clinical significance of anticentromere antibodies.

1982 • 110 citations

Autoantibody to th ribonucleoprotein (nucleolar 7–2 rna protein particle) in patients with systemic sclerosis

1990 • 109 citations

Topoisomerase I identified by scleroderma 70 antisera: enrichment of topoisomerase I at the centromere in mouse mitotic cells before anaphase.

1986 • 108 citations

Characterization of human MRP/Th RNA and its nuclear gene: full length MRP/Th RNA is an active endoribonuclease when assembled as an RNP

1990 • 107 citations

Anticentromere antibody

1983 • 104 citations

Anti-fibrillarin autoantibodies in mercury-treated mice.

1989 • 100 citations

T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors.

1995 • 99 citations

The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma).

1993 • 98 citations

Analysis of the autoantibody response to fibrillarin in human disease and murine models of autoimmunity.

1995 • 98 citations

Anticentromere antibodies in primary biliary cirrhosis

1983 • 97 citations

7-2/MRP RNAs in plant and mammalian cells: association with higher order structures in the nucleolus.

1992 • 97 citations

Antitopoisomerase I monoclonal autoantibodies from scleroderma patients and tight skin mouse interact with similar epitopes.

1992 • 96 citations

Disruption of centromere assembly during interphase inhibits kinetochore morphogenesis and function in mitosis

1991 • 96 citations

Racial differences in antinuclear antibody patterns and clinical manifestations of scleroderma

1989 • 93 citations

The analysis of antinuclear and antinucleolar autoantibodies of scleroderma by radioimmunoprecipitation assays

1990 • 91 citations

A long‐term longitudinal study of anticentromere antibodies

1984 • 90 citations

Association of polar amino acids at position 26 of the HLA-DQB1 first domain with the anticentromere autoantibody response in systemic sclerosis (scleroderma).

1992 • 88 citations

Cloning and characterization of the cDNA coding for a polymyositis-scleroderma overlap syndrome-related nucleolar 100-kD protein.

1992 • 88 citations

Scl 70 antibody—a specific marker of systemic sclerosis

1986 • 87 citations

Scl-86, a marker antigen for diffuse scleroderma.

1985 • 85 citations

Nuclear RNase MRP processes RNA at multiple discrete sites: interaction with an upstream G box is required for subsequent downstream cleavages.

1991 • 80 citations

Cloning of a complementary DNA coding for the 100-kD antigenic protein of the PM-Scl autoantigen.

1992 • 76 citations

Racial Differences in the Frequencies of Scleroderma‐Related Autoantibodies

1992 • 74 citations

Antibodies to distinct polypeptides of RNA polymerase I in sera from patients with rheumatic autoimmune disease.

1982 • 70 citations

Antibodies in human serum that precipitate ribonuclease P.

1988 • 69 citations

T and B cell collaboration is essential for the autoantibody response to DNA topoisomerase I in systemic sclerosis.

1995 • 67 citations

Autoantibodies to RNA polymerase II are common in systemic lupus erythematosus and overlap syndrome. Specific recognition of the phosphorylated (IIO) form by a subset of human sera.

1994 • 66 citations

Recognition of peptides that are immunopathogenic but cryptic. Mechanisms that allow lymphocytes sensitized against cryptic peptides to initiate pathogenic autoimmune processes.

1991 • 65 citations

Identification of protein components reactive with anti-PM/Scl autoantibodies

1990 • 65 citations

The 40-kilodalton to autoantigen associates with nucleotides 21 to 64 of human mitochondrial RNA processing/7-2 RNA in vitro.

1991 • 60 citations

Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and III.

1993 • 56 citations

Detection of anticentromere antibodies using cloned autoantigen cenp‐Bl

1987 • 56 citations

Severe systemic sclerosis with anti-topoisomerase I Antibodies is associated with an HLA-DRw11 allele

1994 • 56 citations

The heterogeneity of anticentromere antibodies in immunoblotting analysis.

1990 • 53 citations

Antifibrillarin autoantibodies present in systemic sclerosis and other connective tissue diseases interact with similar epitopes.

1995 • 51 citations

Autoantibodies to topoisomerase I (Scl-70): Analysis by gel diffusion, immunoblot, and enzyme-linked immunosorbent assay

1990 • 51 citations

Use of molecular cloning methods to map the distribution of epitopes on topoisomerase I (Scl‐70) recognized by sera of scleroderma patients

1990 • 47 citations

Anti-centromere antibodies (ACA) in systemic sclerosis patients and their relatives: a serological and HLA study

1994 • 46 citations

Autoantigenic epitopes on dna topoisomerase i

1993 • 45 citations

Characterization and immunolocalization of a nucleolar antigen with anti-NOR serum in HELA cells

1992 • 45 citations

Anti-Scl-70 antibodies detected by immunoblotting in progressive systemic sclerosis: specificity and clinical correlations.

1989 • 43 citations

Systemic sclerosis (scleroderma): clinical, genetic, and serologic subsets.

1987 • 41 citations

HLA class II genes associated with anticentromere antibody in Japanese patients with systemic sclerosis (scleroderma).

1995 • 41 citations

Association of autoantibodies to topoisomerase I and the phosphorylated (IIO) form of RNA polymerase II in Japanese scleroderma patients.

1994 • 41 citations

A molecular and serologic analysis of the major histocompatibility complex and complement component c4 in systemic sclerosis

1993 • 39 citations

Specificity of antinuclear antibodies in primary biliary cirrhosis.

1995 • 37 citations

Identification and characterization of mitochondria autoantigens in progressive systemic sclerosis: identity with the 72,000 dalton autoantigen in primary biliary cirrhosis.

1986 • 36 citations

Frequency and clinical significance of anticentromere and anti Scl-70 antibodies in an English connective tissue disease population

1983 • 35 citations

Anticentromere antibody: an immunological marker of a subset of systemic sclerosis

1985 • 34 citations

HLA and ethnic associations among systemic sclerosis patients with anticentromere antibodies

1995 • 33 citations

Human RNaseP RNA and nucleolar 7-2 RNA share conserved ?To? antigen-binding domains

1994 • 32 citations

Analysis of the specificity of anti‐pm‐scl autoantibodies

1994 • 32 citations

Anticentromere Autoantibodies

1994 • 31 citations

Detection of Anti-DNA Topoisomerase I Antibody by an Enzyme-Linked Immunosorbent Assay Using Overlapping Recombinant Polypeptides

1995 • 30 citations

Antinuclear antibodies in progressive systemic sclerosis.

1985 • 29 citations

DNA-DR typing shows HLA-DRw11 RFLPs are increased in frequency in both progressive systemic sclerosis and CREST variants of scleroderma

1989 • 27 citations

Scl-95/100: doublet of endothelial marker autoantigens in progressive systemic sclerosis.

1986 • 23 citations

B cell epitopes on nuclear autoantigens

1994 • 23 citations

A recombinant topoisomerase I ELISA: screening for IgG, IgM and IgA anti-topo I autoantibodies in human sera

1992 • 20 citations

[Antinuclear antibodies in progressive systemic sclerosis].

1986 • 19 citations

IDENTIFICATION OF A UNIVERSAL B CELL EPITOPE ON DNA TOPOISOMERASE I, AN AUTOANTIGEN ASSOCIATED WITH SCLERODERMA

1993 • 18 citations

Serological Profiles as Prognostic Clues for Progressive Systemic Scleroderma: The Italian Experience

1991 • 18 citations

HLA-DQB1 Associations with Anti-topoisomerase-1 Antibodies in Patients with Systemic Sclerosis and their First Degree Relatives

1994 • 16 citations

FREQUENCY OF AUTOANTIBODIES TO A MAJOR EPITOPE ON THE CARBOXYL TERMINAL FRAGMENT OF CENP-B IN PATIENTS WITH AUTOIMMUNE DISEASE

1995 • 15 citations

Autoantibodies against topoisomerase I detected with the natural enzyme and overlapping recombinant peptides

1993 • 15 citations

Autoantibodies against RNA polymerase I in scleroderma and Sjögren's syndrome scera

1987 • 14 citations

Scl-70 antigen stability and its effect on antibody detection in scleroderma.

1988 • 13 citations

Detection of anti-topoisomerase I antibodies using a full length human topoisomerase I recombinant protein purified from a baculovirus expression system

1995 • 12 citations

Genetic and immunological differences between Japanese patients with diffuse scleroderma and limited scleroderma.

1994 • 11 citations