CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins

1999 • 689 citations

From T to B and back again: positive feedback in systemic autoimmune disease

2001 • 553 citations

Abnormal B lymphocyte delevopment, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule

1995 • 546 citations

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

1996 • 437 citations

Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection

1995 • 394 citations

The CD19–CD21 Complex Regulates Signal Transduction Thresholds Governing Humoral Immunity and Autoimmunity

1997 • 379 citations

Stimulation of Collagen and Glycosaminoglycan Production in Cultured Human Adult Dermal Fibroblasts by Recombinant Human Interleukin 6

1991 • 315 citations

Quantitative Genetic Variation in CD19 Expression Correlates with Autoimmunity

2000 • 314 citations

A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation.

1996 • 290 citations

CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity.

1996 • 263 citations

CD19 Regulates Src Family Protein Tyrosine Kinase Activation in B Lymphocytes through Processive Amplification

2000 • 211 citations

CD19-Regulated Signaling Thresholds Control Peripheral Tolerance and Autoantibody Production in B Lymphocytes

1997 • 193 citations

Endogenous IL-1α from systemic sclerosis fibroblasts induces IL-6 and PDGF-A

1999 • 178 citations

The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation.

1995 • 158 citations

Rac1 mediates STAT3 activation by autocrine IL-6

2001 • 150 citations

CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19.

1997 • 148 citations

Autoantibodies to the Extracellular Matrix Microfibrillar Protein, Fibrillin-1, in Patients with Scleroderma and Other Connective Tissue Diseases

1999 • 132 citations

CD19 Amplifies B Lymphocyte Signal Transduction by Regulating Src-Family Protein Tyrosine Kinase Activation

1999 • 120 citations

Lack of Skin Fibrosis in Tight Skin (TSK) Mice with Targeted Mutation in the Interleukin-4Rα and Transforming Growth Factor-β Genes

2001 • 116 citations

The Tight Skin Mouse: Demonstration of Mutant Fibrillin-1 Production and Assembly into Abnormal Microfibrils

1998 • 116 citations

Disrupting the IL-4 gene rescues mice homozygous for the tight-skin mutation from embryonic death and diminishes TGF-β production by fibroblasts

2002 • 107 citations

Enhanced production of interleukin-6 (IL-6), oncostatin M and soluble IL-6 receptor by cultured peripheral blood mononuclear cells from patients with systemic sclerosis

1999 • 94 citations

New Insights into the Assembly of Extracellular Microfibrils from the Analysis of the Fibrillin 1 Mutation in the Tight skin Mouse

2000 • 92 citations

A role for CD4⁺ T cells in the pathogenesis of skin fibrosis in tight skin mice

1994 • 81 citations

Induction of Skin Fibrosis and Autoantibodies by Infusion of Immunocompetent Cells from Tight Skin Mice into C57BL/6 Pa/Pa Mice

1993 • 74 citations

Specificities and V genes encoding monoclonal autoantibodies from viable motheaten mice.

1988 • 66 citations

Spontaneous Occurrence of Anti-Fibrillin-1 Autoantibodies in Tight-Skin Mice

1998 • 62 citations

B-cell Deficiency does not Abrogate Development of Cutaneous Hyperplasia in Mice Inheriting the Defective Fibrillin-1 Gene

1997 • 50 citations

Autoantibodies in scleroderma and tightskin mice

1994 • 45 citations

The role of mast cells in the development of skin fibrosis in tight-skin mutant mice

1995 • 39 citations

Induction of Skin Fibrosis in Mice Expressing a Mutated Fibrillin-1 Gene

2000 • 35 citations

Correlation between the Concentration of Serum Anti-topoisomerase I Autoantibodies and Histological and Biochemical Alterations in the Skin of Tight Skin Mice

1996 • 35 citations

Development of the tight-skin phenotype in immune-deficient mice

2001 • 30 citations