Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

1995 • 551 citations

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

1996 • 437 citations

CD22 is a negative regulator of B-cell receptor signalling

1997 • 427 citations

CD22 regulates thymus-independent responses and the lifespan of B cells

1996 • 395 citations

Immune regulation by the ST6Gal sialyltransferase

1998 • 352 citations

The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells

1991 • 348 citations

Deficiency in CD22, a B Cell–specific Inhibitory Receptor, Is Sufficient to Predispose to Development of High Affinity Autoantibodies

1999 • 321 citations

Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell–cell interactions and signalling

2002 • 309 citations

Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains.

1994 • 268 citations

Sweet 'n' sour: the impact of differential glycosylation on T cell responses

2002 • 258 citations

Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes

1998 • 249 citations

Siglecs in the immune system

2001 • 247 citations

Differential expression of five sialyltransferase genes in human tissues.

1994 • 246 citations

Identification and Characterization of a Novel Siglec, Siglec-7, Expressed by Human Natural Killer Cells and Monocytes

1999 • 239 citations

Sialoside Specificity of the Siglec Family Assessed Using Novel Multivalent Probes

2003 • 232 citations

Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition.

1993 • 222 citations

Tuning Antigen Receptor Signaling by CD22: Integrating Cues from Antigens and the Microenvironment

1997 • 195 citations

The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion

1990 • 192 citations

A Small Region of the Natural Killer Cell Receptor, Siglec-7, Is Responsible for Its Preferred Binding to α2,8-Disialyl and Branched α2,6-Sialyl Residues

2002 • 186 citations

The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound

2002 • 180 citations

The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.

1993 • 173 citations

Loss of N-Glycolylneuraminic Acid in Human Evolution

2000 • 160 citations

Functional groups of sialic acids involved in binding to siglecs (sialoadhesins) deduced from interactions with synthetic analogues

1998 • 156 citations

Binding of Human Plasma Sialoglycoproteins by the B Cell-specific Lectin CD22

1995 • 136 citations

Inhibition of T Cell Receptor-Coreceptor Interactions by Antagonist Ligands Visualized by Live FRET Imaging of the T-Hybridoma Immunological Synapse

2002 • 132 citations

Characterization of Sialyloligosaccharide Binding by Recombinant Soluble and Native Cell-associated CD22

1995 • 119 citations

Identification of CD22 Ligands on Bone Marrow Sinusoidal Endothelium Implicated in CD22-dependent Homing of Recirculating B Cells

1999 • 115 citations

Interaction of CD22 with α2,6-linked sialoglycoconjugates: innate recognition of self to dampen B cell autoreactivity?

2002 • 111 citations

I-type lectins

2002 • 110 citations

The measurement of lymphocyte volume: importance of reference particle deformability and counting solution tonicity

1981 • 101 citations

Tissue-specific alternative splicing of the beta-galactoside alpha 2,6-sialyltransferase gene.

1992 • 100 citations

Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation

1999 • 99 citations

Sialic Acid Binding Domains of CD22 Are Required For Negative Regulation of B Cell Receptor Signaling

2002 • 99 citations

Regulation of CD45 engagement by the B-cell receptor CD22.

1995 • 91 citations

CD22-mediated stimulation of T cells regulates T-cell receptor/CD3-induced signaling.

1992 • 90 citations

Ig domains 1 and 2 of murine CD22 constitute the ligand-binding domain and bind multiple sialylated ligands expressed on B and T cells.

1995 • 87 citations

A Second Uniquely Human Mutation Affecting Sialic Acid Biology

2001 • 86 citations

Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation

1996 • 83 citations

Tissue-specific Expression of β-Galactoside α-2,6-Sialyltransferase

1989 • 79 citations

Constitutively unmasked CD22 on B cells of ST6Gal I knockout mice: novel sialoside probe for murine CD22

2002 • 64 citations

Comparison of CD22 binding to native CD45 and synthetic oligosaccharide

2002 • 59 citations

A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: implications for B‐cell homing to the bone marrow

2000 • 51 citations

The B Cell Coreceptor CD22 Associates with AP50, a Clathrin-Coated Pit Adapter Protein, Via Tyrosine-Dependent Interaction

2003 • 50 citations

Chemically Defined Sialoside Scaffolds for Investigation of Multivalent Interactions with Sialic Acid Binding Proteins^†

2003 • 48 citations

Transitional and marginal zone B cells have a high proportion of unmasked CD22: implications for BCR signaling

2003 • 47 citations

Sialylation of the Sialic Acid Binding Lectin Sialoadhesin Regulates Its Ability to Mediate Cell Adhesion

1999 • 40 citations

Signal Transduction via the B-cell Antigen Receptor: The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases

2000 • 39 citations

Lymph node macrophages, but not spleen macrophages, express high levels of unmasked sialoadhesin: implication for the adhesive properties of macrophages in vivo

2002 • 39 citations

Receptor Modulators of B-Cell Receptor Signalling — CD19/CD22

2000 • 31 citations

Transcription of the -galactoside 2,6-sialyltransferase gene (SIAT1) in B-lymphocytes: cell type-specific expression correlates with presence of the divergent 5'-untranslated sequence

1999 • 24 citations

A CD45 minigene restores regulated isoform expression and immune function in CD45-deficient mice: therapeutic implications for human CD45-null severe combined immunodeficiency

2003 • 16 citations

Expression of receptors for Fc portion of IgM (Fc.MU.R) and surface neuraminic acid on the human peripheral lymphocytes.

1985 • 4 citations

Sialylation of the Sialic Acid Binding Lectin Sialoadhesin Regulates Its Ability to Mediate Cell Adhesion

1999 • 4 citations