Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis

A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP

1995 • 551 citations

Hyperresponsive B Cells in CD22-Deficient Mice

1996 • 530 citations

CD22 Is Both a Positive and Negative Regulator of B Lymphocyte Antigen Receptor Signal Transduction: Altered Signaling in CD22-Deficient Mice

1996 • 437 citations

CD22 is a negative regulator of B-cell receptor signalling

1997 • 427 citations

Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily

1994 • 406 citations

CD22 regulates thymus-independent responses and the lifespan of B cells

1996 • 395 citations

Siglecs, sialic acids and innate immunity

2001 • 383 citations

Immune regulation by the ST6Gal sialyltransferase

1998 • 352 citations

The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells

1991 • 348 citations

CD22, A B LYMPHOCYTE–SPECIFIC ADHESION MOLECULE THAT REGULATES ANTIGEN RECEPTOR SIGNALING^*

1997 • 296 citations

Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies.

1989 • 255 citations

Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes

1998 • 249 citations

CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.

1993 • 243 citations

Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition.

1993 • 222 citations

Tuning Antigen Receptor Signaling by CD22: Integrating Cues from Antigens and the Microenvironment

1997 • 195 citations

CD22 associates with the human surface IgM-B-cell antigen receptor complex.

1993 • 185 citations

The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound

2002 • 180 citations

The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.

1993 • 173 citations

Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact

2004 • 170 citations

Association of CD22 with the B cell antigen receptor

1993 • 157 citations

The oligosaccharide binding specificities of CD22 beta, a sialic acid-specific lectin of B cells.

1994 • 153 citations

cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions.

1991 • 152 citations

Localization of the Putative Sialic Acid-binding Site on the Immunoglobulin Superfamily Cell-surface Molecule CD22

1996 • 143 citations

Tyrosine Phosphorylation of CD22 During B Cell Activation

1992 • 139 citations

Binding of Human Plasma Sialoglycoproteins by the B Cell-specific Lectin CD22

1995 • 136 citations

A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma.

2000 • 119 citations

Characterization of Sialyloligosaccharide Binding by Recombinant Soluble and Native Cell-associated CD22

1995 • 119 citations

Constitutive endocytosis and degradation of CD22 by human B cells.

1995 • 116 citations

Recombinant RFB4 Immunotoxins Exhibit Potent Cytotoxic Activity for CD22-Bearing Cells and Tumors

1997 • 115 citations

Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand.

1995 • 112 citations

B cell antigen receptor-mediated apoptosis. Importance of accessory molecules CD19 and CD22, and of surface IgM cross-linking.

1995 • 100 citations

Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation

1999 • 99 citations

Sialic Acid Binding Domains of CD22 Are Required For Negative Regulation of B Cell Receptor Signaling

2002 • 99 citations

Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule.

1992 • 99 citations

CD22-mediated Cell Adhesion to Cytokine-activated Human Endothelial Cells

1995 • 90 citations

Sialylation of the B lymphocyte molecule CD22 by alpha 2,6-sialyltransferase is implicated in the regulation of CD22-mediated adhesion.

1994 • 79 citations

Regulation of lymphocyte activation by the cell-surface molecule CD22

1994 • 71 citations

Evaluation of four CD22 antibodies as ricin a chain‐containing immunotoxins for the in vivo therapy of human B‐cell leukemias and lymphomas

1988 • 71 citations

Immunotoxins against CD19 and CD22 are effective in killing precursor-B acute lymphoblastic leukemia cells in vitro

2000 • 64 citations

Constitutively unmasked CD22 on B cells of ST6Gal I knockout mice: novel sialoside probe for murine CD22

2002 • 64 citations

The B Cell Coreceptor CD22 Associates with AP50, a Clathrin-Coated Pit Adapter Protein, Via Tyrosine-Dependent Interaction

2003 • 50 citations

Treatment of SCID/human B cell precursor ALL with anti-CD19 and anti-CD22 immunotoxins

2003 • 49 citations

Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of90Y-DOTA-peptide-Lym-1 in lymphoma xenografts

2003 • 46 citations

The use of radioimmunoconjugates in stem cell transplantation

2002 • 41 citations

Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins

2001 • 41 citations

Internalization of the Lymphocytic Surface Protein CD22 Is Controlled by a Novel Membrane Proximal Cytoplasmic Motif

1998 • 19 citations

Differential response of malignant human B-cells to anti-IgM immunoglobulin (anti-mu) and B-cell growth factor: unique direct cytotoxicity of anti-mu on prolymphocytic leukemia cells

1990 • 15 citations

Differential response of malignant human B-cells to anti-IgM immunoglobulin (anti-mu) and B-cell growth factor: unique direct cytotoxicity of anti-mu on prolymphocytic leukemia cells

1990 • 2 citations