Proteasomes are regulated by interferon gamma: implications for antigen processing.

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Association of class I major histocompatibility heavy and light chains induced by viral peptides

1989 • 995 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

1990 • 717 citations

Cytotoxic T cells recognize fragments of the influenza nucleoprotein

1985 • 669 citations

Mechanisms of Intracellular Protein Breakdown

1982 • 647 citations

A gene in the human major histocompatibility complex class II region controlling the class I antigen presentation pathway

1990 • 644 citations

Genes regulating HLA class I antigen expression in T-B lymphoblast hybrids

1985 • 580 citations

The multicatalytic proteinase complex, a major extralysosomal proteolytic system

1990 • 464 citations

Transport Protein Genes in the Murine MHC: Possible Implications for Antigen Processing

1990 • 438 citations

A proteasome-related gene between the two ABC transporter loci in the class II region of the human MHC

1991 • 427 citations

MHC class II region encoding proteins related to the muKidrug resistance family of transmembrane transporters

1990 • 426 citations

Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter

1991 • 413 citations

Second proteasome-related gene in the human MHC class II region

1991 • 348 citations

Brefeldin A Specifically Inhibits Presentation of Protein Antigens to Cytotoxic T Lymphocytes

1989 • 329 citations

A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution.

1986 • 327 citations

The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.

1990 • 327 citations

Brefeldin A implicates egress from endoplasmic reticulum in class I restricted antigen presentation

1989 • 317 citations

Structural and serological similarity of MHC-linked LMP and proteasome (multicatalytic proteinase) complexes

1991 • 310 citations

Subunit of the '20S' proteasome (multicatalytic proteinase) encoded by the major histocompatibility complex

1991 • 262 citations

Homology of proteasome subunits to a major histocompatibility complex-linked LMP gene

1991 • 256 citations

Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates.

1987 • 255 citations

Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase. Characterization as a high molecular weight cysteine proteinase.

1985 • 244 citations

The multicatalytic proteinase of mammalian cells

1989 • 242 citations

Natural substrates of the Ubiquitin proteolytic pathway

1991 • 238 citations

Regulation of Cytokine Gene Expression

1988 • 234 citations

A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation.

1988 • 161 citations

Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits.

1990 • 127 citations

Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome)

1991 • 99 citations

Molecular cloning and functional analysis of three subunits of yeast proteasome.

1991 • 97 citations

Skeletal muscle proteasome can degrade proteins in an ATP-dependent process that does not require ubiquitin.

1989 • 93 citations

Half-life of proteasomes (multiprotease complexes) in rat liver

1989 • 87 citations

Subcellular fractionation of tissue culture cells

1989 • 61 citations

Interaction of human erythrocyte multicatalytic proteinase with polycations

1990 • 38 citations

Molecular Cloning and Functional Analysis of Three Subunits of Yeast Proteasome

1991 • 28 citations

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