Ceramide: A stress signal and mediator of growth suppression and apoptosis

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Inositol phosphates and cell signalling

1989 • 4,058 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

p53 function and dysfunction

1992 • 1,918 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

The sphingomyelin cycle and the second messenger function of ceramide.

1994 • 1,255 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.

1994 • 890 citations

c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines.

1994 • 747 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

Ceramide activates heterotrimeric protein phosphatase 2A

1993 • 657 citations

Sphingomyelin turnover induced by vitamin D3 in HL-60 cells

1989 • 629 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

Apoptosis: a different type of cell death

1992 • 523 citations

Apoptosis-the molecular basis of cell death

1992 • 517 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Ceramide stimulates a cytosolic protein phosphatase.

1992 • 406 citations

Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha.

1991 • 376 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells

1991 • 330 citations

Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.

1993 • 305 citations

Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.

1994 • 288 citations

Inhibition of DNA Fragmentation in Thymocytes and Isolated Thymocyte Nuclei by Agents That Stimulate Protein Kinase C

1989 • 276 citations

Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide.

1992 • 272 citations

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

1990 • 265 citations

Arachidonic acid-selective cytosolic phospholipase A2 is crucial in the cytotoxic action of tumor necrosis factor

1993 • 253 citations

Crosstalk among multiple signal-activated phospholipases

1992 • 241 citations

Signal Transduction Pathways in Apoptosis

1996 • 224 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.

1993 • 217 citations

Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase.

1994 • 205 citations

Human 55-kDa receptor for tumor necrosis factor coupled to signal transduction cascades.

1992 • 197 citations

Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.

1994 • 188 citations

1-beta-D-Arabinofuranosylcytosine stimulates ceramide and diglyceride formation in HL-60 cells.

1994 • 166 citations

Role of protein kinase C and the Na+/H+ antiporter in suppression of apoptosis by granulocyte macrophage colony-stimulating factor and interleukin-3.

1992 • 158 citations

Activation of the Abelson tyrosine kinase activity is associated with suppression of apoptosis in hemopoietic cells.

1993 • 157 citations

Ceramide Mediates the Apoptotic Response of WEHI 231 Cells to Anti-immunoglobulin, Corticosteroids and Irradiation

1994 • 129 citations

A dominant negative protein kinase C zeta subspecies blocks NF-kappa B activation.

1993 • 128 citations

Involvement of phospholipase A2 activation in tumour cell killing by tumour necrosis factor.

1988 • 124 citations

Programmed cell death (apoptosis) is induced rapidly and with positive cooperativity by activation of cyclic adenosine monophosphate‐kinase I in a myeloid leukemia cell line

1991 • 120 citations

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence

1994 • 117 citations

Changes in bioactive lipids, alkylacylglycerol and ceramide, occur in HIV-infected cells

1992 • 106 citations

Mitogenic and cytotoxic actions of tumor necrosis factor in BALB/c 3T3 cells

1989 • 98 citations

Tyrosine kinase(s) regulate apoptosis and bcl-2 expression in a growth factor-dependent cell line.

1993 • 98 citations

Ceramide-activated protein phosphatase: partial purification and relationship to protein phosphatase 2A.

1993 • 93 citations

Ceramide regulates oxidant release in adherent human neutrophils

1994 • 77 citations

Cellular signaling in thymocyte apoptosis.

1992 • 75 citations

Microinjected Catalytic Subunit of cAMP-Dependent Protein Kinase Induces Apoptosis in Myeloid Leukemia (IPC-81) Cells

1993 • 69 citations

Differential Expression and Subcellular Localization of Protein Kinase C α, β, γ, δ, and ɛ Isoforms in SH‐SY5Y Neuroblastoma Cells: Modifications During Differentiation

1993 • 68 citations

Dissociation of endogenous cellular ceramide from NF-kappa B activation.

1994 • 67 citations

Tumor necrosis factor α stimulates sphingomyelinase through the 55 kDa receptor in HL‐60 cells

1992 • 61 citations

Role of Protein Kinase-C in Thymocyte Apoptosis Induced by Irradiation

1992 • 52 citations

Calyculin A, a Potent Inhibitor of Phosphatase-1 and -2A, Prevents Apoptosis

1993 • 52 citations

Brefeldin A promotes hydrolysis of sphingomyelin.

1992 • 36 citations

Protection against Apoptosis in Chicken Bursa Cells by Phorbol Ester in Vitro

1993 • 32 citations

Intracellular Ca²⁺and Cytotoxicity

1989 • 20 citations