Apoptosis and the cell cycle

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

1994 • 2,025 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1994 • 1,669 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Genetic Control of the Cell Division Cycle in Yeast

1974 • 1,588 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

1984 • 1,463 citations

Shrinkage necrosis: A distinct mode of cellular death

1971 • 1,448 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

A Restriction Point for Control of Normal Animal Cell Proliferation

1974 • 1,389 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY

1951 • 1,194 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Death in Embryonic Systems

1966 • 943 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

1991 • 884 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Induction of WAF1/CIP1 by a p53-independent pathway.

1994 • 773 citations

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

1970 • 759 citations

Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA

1993 • 758 citations

Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell Hybridomas

1992 • 705 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15.

1992 • 638 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Premature p34 ^cdc2 Activation Required for Apoptosis

1994 • 568 citations

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

1994 • 564 citations

Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro

1994 • 559 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Apoptosis-the molecular basis of cell death

1992 • 517 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin.

1991 • 468 citations

Nuclear events of apoptosis in vitro in cell-free mitotic extracts: a model system for analysis of the active phase of apoptosis.

1993 • 452 citations

Cdc25A is a novel phosphatase functioning early in the cell cycle.

1994 • 442 citations

Wild-type p53 suppresses growth of human prostate cancer cells containing mutant p53 alleles.

1991 • 440 citations

Extreme sensitivity of some intestinal crypt cells to X and γ irradiation

1977 • 417 citations

The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents.

1993 • 403 citations

Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

1992 • 401 citations

Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication

1993 • 389 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Cascade Induction of c-fos, c-myc, and Heat Shock 70K Transcripts during Regression of the Rat Ventral Prostate Gland

1988 • 355 citations

The 19-Kilodalton Adenovirus E1B Transforming Protein Inhibits Programmed Cell Death and Prevents Cytolysis by Tumor Necrosis Factor α

1992 • 354 citations

Activation of cyclin A-dependent protein kinases during apoptosis.

1994 • 352 citations

Cell death by apoptosis during involution of the lactating breast in mice and rats

1989 • 341 citations

Induction of c-fos during myelomonocytic differentiation and macrophage proliferation

1985 • 340 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

Perspectives on mammalian cell death

1988 • 334 citations

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1992 • 331 citations

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

1993 • 329 citations

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

1993 • 325 citations

Differential modulation of cyclin gene expression by MYC.

1993 • 321 citations

Sequential protooncogene expression during rat liver regeneration.

1986 • 302 citations

Cell cycle-specific effects of lovastatin.

1991 • 301 citations

Deletion of cells by apoptosis during castration-induced involution of the rat prostate

1973 • 285 citations

Cyclin A is required in S phase in normal epithelial cells

1992 • 273 citations

p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation.

1994 • 264 citations

Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact.

1986 • 254 citations

Anti‐immunoglobulin antibodies induce apoptosis in immature B cell lymphomas

1990 • 253 citations

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle

1993 • 252 citations

Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.

1993 • 247 citations

Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus.

1994 • 247 citations

Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle.

1992 • 245 citations

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

1992 • 242 citations

Anti‐immunoglobulins induce death by apoptosis in WEHI‐231 B lymphoma cells

1990 • 239 citations

Activation-induced apoptosis in lymphocytes

1994 • 238 citations

Apoptosis Biochemical events and relevance to cancer chemotherapy

1992 • 238 citations

Cell growth cycle block of T cell hybridomas upon activation with antigen.

1987 • 235 citations

CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle.

1992 • 230 citations

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

1990 • 222 citations

The transactivator proteins VP16 and GAL4 bind replication factor A

1993 • 216 citations

Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.

1990 • 209 citations

Participation of cyclin A in Myc-induced apoptosis.

1994 • 207 citations

Cell cycle-specific effects of tumor necrosis factor.

1984 • 204 citations

The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells.

1993 • 203 citations

Dexamethasone induces irreversible G₁ arrest and death of a human lymphoid cell line

1979 • 201 citations

Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions.

1992 • 200 citations

The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.

1992 • 199 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA

1984 • 195 citations

Cyclic bcl-2 gene expression in human uterine endometrium during menstrual cycle

1994 • 185 citations

Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells.

1994 • 180 citations

Adrenocortical cell deletion: The role of ACTH

1973 • 180 citations

Occurrence of cell death (apoptosis) during the involution of liver hyperplasia.

1985 • 174 citations

Cell death in spermatogenesis

1987 • 174 citations

Preparations of lymphotoxin induce resistance to their own cytotoxic effect.

1984 • 168 citations

Death by suicide: one way to go in mammalian cellular development?

1991 • 167 citations

Bcl-2 protein expression during murine development.

1994 • 164 citations

c-myc protein expression in untransformed fibroblasts.

1991 • 163 citations

The regulation of growth and differentiation of a murine B cell lymphoma. II. The inhibition of WEHI 231 by anti-immunoglobulin antibodies.

1981 • 158 citations

Mutations in the gene encoding the adenovirus early region 1B 19,000-molecular-weight tumor antigen cause the degradation of chromosomal DNA

1984 • 156 citations

Hormonal control of apoptosis in hamster uterine luminal epithelium

1979 • 156 citations

Biochemistry and Cell Biology of Amphibian Metamorphosis with a Special Emphasis on the Mechanism of Removal of Larval Organs

1990 • 155 citations

Drawings of British Plants, Being Illustrations of the Species of Flowering Plants Growing Naturally in the British Isles. Parts I-III: Ranunculaceae to Cruciferae.Stella Ross-Craig

1951 • 154 citations

Induction of apoptosis during normal and neoplastic B-cell development in the bursa of Fabricius.

1991 • 153 citations

Quantitative histological and histochemical studies on the occurrence and stages of controlled cell death (apoptosis) during regression of rat liver hyperplasia

1986 • 144 citations

The cell cycle and cell death

1993 • 137 citations

Distinct roles of cdk2 and cdc2 in RP-A phosphorylation during the cell cycle

1993 • 136 citations

Interaction of adenoviral proteins with pRB and p53

1993 • 134 citations

Cell death in the normal neonatal rat adrenal cortex

1973 • 121 citations

Interferons and interleukin 6 suppress phosphorylation of the retinoblastoma protein in growth-sensitive hematopoietic cells.

1992 • 120 citations

Cyclin E and cyclin A as candidates for the restriction point protein.

1993 • 119 citations

Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells.

1991 • 117 citations

The effects of testosterone, 5α-dihydrotestosterone and adenosine 3′,5′-monophosphate on cell proliferation and differentiation in RAT prostate

1973 • 115 citations

The induction of apoptosis by chemotherapeutic agents occurs in all phases of the cell cycle.

1992 • 113 citations

Lymphoma models for B cell activation and tolerance. III. Cell cycle dependence for negative signalling of WEHI-231 B lymphoma cells by anti-mu.

1986 • 112 citations

Chemically induced premature mitosis: differential response in rodent and human cells and the relationship to cyclin B synthesis and p34cdc2/cyclin B complex formation.

1991 • 106 citations

Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53.

1994 • 106 citations

Ultrastructural changes in the theca interna during follicular atresia in sheep

1978 • 101 citations

Cell Cycle Arrest of Proliferating Neuronal Cells by Serum Deprivation Can Result in Either Apoptosis or Differentiation

1993 • 100 citations

ELECTRON MICROSCOPE OBSERVATIONS ON TINGIBLE BODY MACROPHAGES IN MOUSE SPLEEN

1963 • 93 citations

19-kDa tumor antigen coded by early region E1b of adenovirus 2 is required for efficient synthesis and for protection of viral DNA.

1984 • 92 citations

Induction of apoptosis by adenovirus type 5 E1A in rat cells requires a proliferation block.

1994 • 90 citations

Nuclear envelope localization of an adenovirus tumor antigen maintains the integrity of cellular DNA.

1984 • 82 citations

Terminal differentiation and apoptosis in experimental lung metastases of human osteogenic sarcoma cells by wild type p53.

1994 • 79 citations

Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.

1994 • 77 citations

Interleukin 1, interleukin 6, tumor necrosis factor, and transforming growth factor beta increase cell resistance to tumor necrosis factor cytotoxicity by growth arrest in the G1 phase of the cell cycle.

1991 • 76 citations

Apoptosis in erythroid progenitors deprived of erythropoietin occurs during the G1 and S phases of the cell cycle without growth arrest or stabilization of wild-type p53.

1994 • 73 citations

Anti-IgM antibody-induced cell death in a human B lymphoma cell line, B104, represents a novel programmed cell death.

1992 • 73 citations

Gene activity during the early phase of androgen-stimulated rat prostate regrowth.

1989 • 72 citations

Lymphoma models for B-cell activation and tolerance

1985 • 69 citations

Requirement for p34cdc2 kinase is restricted to mitosis in the mammalian cdc2 mutant FT210

1992 • 65 citations

Anti-immunoglobulin treatment of murine B-cell lymphomas induces active transforming growth factor beta but pRB hypophosphorylation is transforming growth factor beta independent.

1992 • 55 citations

Cell-mediated cytotoxic mechanisms

1994 • 53 citations

Growth inhibition and cytotoxicity of tumor necrosis factor in L929 cells is enhanced by high cell density and inhibition of mRNA synthesis.

1986 • 52 citations

Increased cyclin A and decreased cyclin D levels in adenovirus 5 E1A-transformed rodent cell lines.

1993 • 49 citations

Staurosporine overrides checkpoints for mitotic onset in BHK cells.

1992 • 43 citations

Fluctuations and ultrastructural localization of oncoproteins and cell cycle regulatory proteins during growth and apoptosis of synchronized AGF cells.

1994 • 42 citations

Regulation of programmed death in erythroid progenitor cells by erythropoietin: Effects of calcium and of protein and RNA syntheses

1992 • 39 citations

Deregulated c-myc expression abrogates the interferon- and interleukin 6-mediated G0/G1 cell cycle arrest but not other inhibitory responses in M1 myeloblastic cells.

1991 • 38 citations

Changes in phosphorylation of myc oncogene and RB antioncogene protein products during growth arrest of the murine lymphoma WEHI 231 cell line.

1991 • 34 citations

Up-regulation of c-myc induces the gene expression of the murine homologues of p34cdc2 and cyclin-dependent kinase-2 in T lymphocytes.

1994 • 32 citations

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.

1993 • 27 citations

Cell cycle specific effects of tumor necrosis factor alpha in monocyte mediated leukemic cell death and the role of beta 2-integrins.

1993 • 27 citations

Expression of Wild-Type p53 Is Not Compatible with - Continued Growth of p53-Negative Tumor Cells

1991 • 27 citations

The role of natural killer cells in the intravascular death of intravenously injected murine tumour cells

1983 • 24 citations

Granzymes and Apoptosis: Targeting the Cell Cycle

1995 • 20 citations

Caffeine potentiates the lethality of tumour necrosis factor in cancer cells

1993 • 20 citations

Inhibition of cytotoxic T lymphocyte-induced target cell DNA fragmentation, but not lysis, by inhibitors of DNA topoisomerases I and II.

1992 • 18 citations

Loss of cell cycle controls in apoptotic lymphoblasts of the bursa of Fabricius.

1994 • 15 citations