Alternatively Spliced EDA Segment Regulates Fibronectin-dependent Cell Cycle Progression and Mitogenic Signal Transduction

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

New Perspectives in Cell Adhesion: RGD and Integrins

1987 • 4,835 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Focal adhesion protein-tyrosine kinase phosphorylated in response to cell attachment to fibronectin.

1992 • 811 citations

Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin.

1989 • 807 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

Three different fibronectin mRNAs arise by alternative splicing within the coding region

1983 • 713 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region

1996 • 621 citations

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α4β1

1990 • 616 citations

Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.

1991 • 578 citations

Adhesive recognition sequences

1991 • 571 citations

Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.

1989 • 489 citations

Integrin signaling: specificity and control of cell survival and cell cycle progression

1997 • 474 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

Fibronectin-Stimulated Signaling from a Focal Adhesion Kinase–c-Src Complex: Involvement of the Grb2, p130^cas, and Nck Adaptor Proteins

1997 • 432 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.

1995 • 415 citations

Characterization of the cell surface heterodimer VLA-4 and related peptides.

1987 • 340 citations

Integrin-mediated Cell Adhesion Promotes Tyrosine Phosphorylation of p130Cas, a Src Homology 3-containing Molecule Having Multiple Src Homology 2-binding Motifs

1995 • 340 citations

A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors.

1989 • 339 citations

Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon.

1987 • 334 citations

The fibronectin isoform containing the ed‐b oncofetal domain: A marker of angiogenesis

1994 • 306 citations

Multiple sites of alternative splicing of the rat fibronectin gene transcript.

1987 • 299 citations

Tyrosine Phosphorylation of p130Cas and Cortactin Accompanies Integrin-mediated Cell Adhesion to Extracellular Matrix

1995 • 289 citations

Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44erk-1 and p42erk-2

1995 • 274 citations

Differential expression of the ed sequence-containing form of cellular fibronectin in embryonic and adult human tissues

1987 • 251 citations

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

1990 • 244 citations

Integrin-mediated Activation of MAP Kinase Is Independent of FAK: Evidence for Dual Integrin Signaling Pathways in Fibroblasts

1997 • 243 citations

VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin.

1990 • 224 citations

Adhesion-induced tyrosine phosphorylation of the p130 SRC substrate

1995 • 223 citations

Human fibronectin: cell specific alternative mRNA splicing generates polypeptide chains dfffering in the number of internal repeats

1984 • 221 citations

Alternative splicing of fibronectin is temporally and spatially regulated in the chicken embryo

1989 • 219 citations

Alternative Splicing of Fibronectin—Many Different Proteins but Few Different Functions

1995 • 206 citations

Macrophages and fibroblasts express embryonic fibronectins during cutaneous wound healing.

1993 • 191 citations

Modulation of Cell-adhesive Activity of Fibronectin by the Alternatively Spliced EDA Segment

1997 • 189 citations

Integrins and inside-out signal transduction: converging signals from PKC and PIP3

1997 • 139 citations

Protein tyrosine phosphatase 1B negatively regulates integrin signaling

1998 • 136 citations

Adhesive properties of the beta 3 integrins: comparison of GP IIb-IIIa and the vitronectin receptor individually expressed in human melanoma cells.

1991 • 115 citations

Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin.

1995 • 104 citations

Activation-dependent alpha5beta1 integrin-mediated adhesion to fibronectin decreases proliferation of chronic myelogenous leukemia progenitors and K562 cells

1996 • 81 citations

Patterns of alternative splicing of fibronectin pre-mRNA in human adult and fetal tissues

1989 • 80 citations

A UV-Responsive G₂ Checkpoint in Rodent Cells

1995 • 79 citations

Regulation of Integrin α5β1 Affinity during Myogenic Differentiation

1995 • 69 citations

Coordinate oncodevelopmental modulation of alternative splicing of fibronectin pre-messenger RNA at ED-A, ED-B, and CS1 regions in human liver tumors.

1993 • 58 citations

A novel cell adhesive protein engineered by insertion of the Arg-Gly-Asp-Ser tetrapeptide

1989 • 32 citations

Distinct Structural Requirements for Interaction of the Integrins α5β1, αvβ5, and αvβ6 with the Central Cell Binding Domain in Fibronectin

1996 • 31 citations

Loss of EDB+ fibronectin isoform is associated with differentiation of alveolar epithelial cells in human fetal lung.

1997 • 19 citations

Probing molecular polymorphism of fibronectins with antibodies directed to the alternatively spliced peptide segments

1989 • 18 citations