NMDA receptors - their role in long-term potentiation

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Magnesium gates glutamate-activated channels in mouse central neurones

1984 • 3,999 citations

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

Excitatory Amino Acid Transmitters

1981 • 2,488 citations

Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.

1983 • 2,376 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

1973 • 1,140 citations

Intracellular injections of EGTA block induction of hippocampal long-term potentiation

1983 • 1,106 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Anticonvulsant Action of Excitatory Amino Acid Antagonists

1982 • 692 citations

Glutamate activates multiple single channel conductances in hippocampal neurons

1987 • 691 citations

Synaptic enhancement in fascia dentata: Cooperativity among coactive afferents

1978 • 665 citations

Potentiation of synaptic transmission in the hippocampus by phorbol esters

1986 • 647 citations

Synapses as associative memory elements in the hippocampal formation

1979 • 573 citations

Long-term potentiation of guinea pig mossy fiber responses is not blocked by N-methyl d-aspartate antagonists

1986 • 545 citations

Translocation of Protein Kinase C Activity May Mediate Hippocampal Long-Term Potentiation

1986 • 532 citations

Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus

1986 • 444 citations

Excitatory amino acid transmission

1987 • 430 citations

Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism

1986 • 416 citations

NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling

1987 • 401 citations

Long-term potentiation of the perforant path in vivo is associated with increased glutamate release

1982 • 387 citations

Involvement of N‐methyl‐D‐aspartate receptors in epileptiform bursting in the rat hippocampal slice.

1986 • 365 citations

Postsynaptic hyperpolarization during conditioning reversibly blocks induction of long-term potentiation

1986 • 324 citations

Correlation between long‐term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats.

1986 • 289 citations

Hippocampal long‐term potentiation is induced by pairing single afferent volleys with intracellular^ injected depolarizing current pulses

1986 • 284 citations

N‐methyl aspartate activates voltage‐dependent calcium conductance in rat hippocampal pyramidal cells.

1983 • 281 citations

Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by d(−)aminophosphonovalerate

1987 • 269 citations

Ketamine and phencyclidine cause a voltage-dependent block of responses to l-aspartic acid

1985 • 261 citations

The relationship between extracellular calcium concentrations and the induction of hippocampal long-term potentiation

1979 • 234 citations

Facilitation of hippocampal long‐lasting potentiation by GABA antagonists

1985 • 224 citations

Magnesium ions block an N-methyl-d-aspartate receptor-mediated component of synaptic transmission in rat hippocampus

1985 • 222 citations

Associative Induction of Posttetanic and Long-Term Potentiation in CA1 Neurons of Rat Hippocampus

1986 • 216 citations

A selective N-methyl-d-aspartate antagonist depresses epileptiform activity in rat hippocampal slices

1985 • 205 citations

Direct relation of long-term synaptic potentiation to phosphorylation of membrane protein F1, a substrate for membrane protein kinase C

1986 • 201 citations

The kindled amygdala model of epilepsy: anticonvulsant action of amino acid antagonists

1983 • 180 citations

Suicide Transport: Destruction of Neurons by Retrograde Transport of Ricin, Abrin, and Modeccin

1982 • 178 citations

Long term potentiation in the hippocampus: mechanisms of initiation and modulation by neurotransmitters

1985 • 174 citations

Effects of phencyclidine, SKF 10,047 and related psychotomimetic agents on N‐methyl‐<scp>d</scp>‐aspartate receptor mediated synaptic responses in rat hippocampal slices

1987 • 170 citations

Calcium-induced long-term potentiation in the hippocampus

1982 • 170 citations

Excitatory amino acids inhibit stimulation of phosphatidylinositol metabolism by aminergic agonists in hippocampus

1986 • 162 citations

On long‐lasting potentiation in the hippocampus. a proposed mechanism for its dependence on coincident pre‐ and postsynaptic activity

1985 • 136 citations

Intracellular demonstration of an N-methyl-d-aspartate receptor mediated component of synaptic transmission in the rat hippocampus

1985 • 135 citations

Increased resting and evoked release of transmitter following repetitive electrical tetanization in hippocampus: a biochemical correlate to long-lasting synaptic potentiation

1981 • 125 citations

Long-Term Potentiation in the Hippocampal Slice: Evidence for Stimulated Secretion of Newly Synthesized Proteins

1981 • 118 citations

Kindling-like stimulus patterns induce epileptiform discharges in the guinea pig in vitro hippocampus

1985 • 95 citations

Phorbol ester promotes growth of synaptic plasticity

1986 • 82 citations

Blockade of long-term potentiation by phencyclidine and σ opiates in the hippocampus in vivo and in vitro

1983 • 81 citations

Cytoplasmic calcium elevation in hippocampal granule cell induced by perforant path stimulation andl-glutamate application

1987 • 75 citations

Tetanic stimulation affects the metabolism of phosphoinositides in hippocampal slices

1984 • 45 citations

The role of inhibitory mechanisms in hippocampal long-term potentiation

1984 • 34 citations

Increased Ca-uptake of presynaptic terminals during long-term potentiation in hippocampal slices

1986 • 27 citations

Kinetics of rat brain NADPH-diaphorase

1987 • 8 citations

N-Methyl-<scp>d</scp>-aspartate increases rat brain synaptosomal free calcium

1987 • 7 citations