Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene

Antibodies, a laboratory manual

1989 • 12,929 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

The Genome of Drosophila Melanogaster

1992 • 3,126 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1992 • 1,632 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

Classical conditioning and retention in normal and mutantDrosophila melanogaster

1985 • 1,170 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTION

1967 • 666 citations

A simple method for site-directed mutagenesis using the polymerase chain reaction

1989 • 607 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

The Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase

1992 • 513 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid β-protein precursor

1989 • 437 citations

Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene

1987 • 406 citations

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain

1988 • 386 citations

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

1989 • 355 citations

Genetic analysis of a drosophila neural cell adhesion molecule: Interaction of fasciclin I and abelson tyrosine kinase mutations

1990 • 340 citations

Genetic Dissection of Behavior

1973 • 327 citations

Platelet Coagulation Factor XI _a -Inhibitor, a Form of Alzheimer Amyloid Precursor Protein

1990 • 299 citations

Protease Nexin-II(amyloid β-protein Precursor): a Platelet α-Granule Protein

1990 • 299 citations

The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid.

1989 • 251 citations

Drosophila abl tyrosine kinase in embryonic CNS axons: A role in axonogenesis is revealed through dosage-sensitive interactions with disabled

1989 • 240 citations

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.

1989 • 212 citations

A Novel mRNA of the A4 Amyloid Precursor Gene Coding for a Possibly Secreted Protein

1989 • 209 citations

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 202 citations

Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate.

1989 • 196 citations

Vision in Drosophila: Genetics of Microbehavior

2011 • 178 citations

Characterization of amalgam: A member of the immunoglobulin superfamily from Drosophila

1988 • 164 citations

Acetylcholinesterase mutants in drosophila and their effects on the structure and function of the cental nervous system

1980 • 164 citations

Analysis of mutants in chaoptin, a photoreceptor cell-specific glycoprotein in Drosophila, reveals its role in cellular morphogenesis

1988 • 161 citations

Most of the yeast genomic sequences are not essential for cell growth and division

1986 • 154 citations

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor

1987 • 146 citations

Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor

1990 • 141 citations

latheo, a new gene involved in associative learning and memory in Drosophila melanogaster, identified from P element mutagenesis.

1992 • 136 citations

Vectors—A survey of molecular cloning vectors and their uses

1988 • 133 citations

NONESSENTIAL SEQUENCES, GENES, AND THE POLYTENE CHROMOSOME BANDS OF DROSOPHILA MELANOGASTER

1978 • 101 citations

The spatial and temporal expression pattern of sevenless is exclusively controlled by gene-internal elements.

1989 • 99 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and neuritic plaque amyloid peptides

1988 • 87 citations

Mutations in a steroid hormone-regulated gene disrupt the metamorphosis of the central nervous system in Drosophila

1991 • 85 citations

The Drosophila transcript encoded by the β-amyloid protein precursor-like gene is restricted to the nervous system

1990 • 73 citations

Genetic activity along 315 kb of the Drosophila chromosome

1984 • 66 citations

The dissonance mutation at the no-on-transient-A locus of D. melanogaster: genetic control of courtship song and visual behaviors by a protein with putative RNA-binding motifs

1992 • 65 citations

Expression of the Drosophila white gene under the control of the hsp70 heat shock promoter

1985 • 63 citations

Reassessment of the effect of biological rhythm mutations on learning in Drosophila melanogaster

1991 • 56 citations

Alzheimer's amyloid precursor protein produced by recombinant baculovirus expression. Proteolytic processing and protease inhibitory properties.

1991 • 54 citations

The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression

1991 • 54 citations

An inducible promoter fused to the period gene in Drosophila conditionally rescues adult per-mutant arrhythmicity

1988 • 51 citations

Physical and functional definition of the Drosophila Notch locus by P element transformation.

1989 • 49 citations

Genetic analysis of a Drosophila microtubule-associated protein.

1992 • 40 citations

GENETIC ANALYSIS OF CHROMOMERE 3D4 IN DROSOPHILA MELANOGASTER: THE DUNCE AND SPERM-AMOTILE GENES

1982 • 37 citations

Locomotor activity in theTyr-1 mutant ofDrosophila melanogaster

1987 • 34 citations