Virus-induced autoimmunity: Epitope spreading to myelin autoepitopes in theiler's virus infection of the central nervous system

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Amino Acid Homology Between the Encephalitogenic Site of Myelin Basic Protein and Virus: Mechanism for Autoimmunity

1985 • 941 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

A genetic basis for familial aggregation in multiple sclerosis

1995 • 626 citations

Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination

1975 • 615 citations

Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.

1995 • 611 citations

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

1997 • 558 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

Epidemiologic evidence for multiple sclerosis as an infection

1993 • 467 citations

T Cells Responsive to Myelin Basic Protein in Patients with Multiple Sclerosis

1990 • 447 citations

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

1996 • 389 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

SPONTANEOUS ENCEPHALOMYELITIS OF MICE, A NEW VIRUS DISEASE

1937 • 301 citations

Primary demyelination in Theiler's virus infection. An ultrastructural study.

1975 • 273 citations

Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls

1991 • 258 citations

Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis

1983 • 243 citations

Theiler's Virus-Induced Demyelination: Prevention by Immunosuppression

1976 • 242 citations

Superantigens: Bacterial and Viral Proteins that Manipulate the Immune System

1993 • 236 citations

Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis

2000 • 212 citations

Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity.

1985 • 207 citations

Characterization of Theiler's murine encephalomyelitis virus (TMEV)-specific delayed-type hypersensitivity responses in TMEV-induced demyelinating disease: correlation with clinical signs.

1986 • 206 citations

Differential Expression of Inflammatory Cytokines Parallels Progression of Central Nervous System Pathology in Two Clinically Distinct Models of Multiple Sclerosis

1998 • 200 citations

Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV)

1990 • 179 citations

The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

1994 • 165 citations

Diversity and plasticity of self recognition during the development of multiple sclerosis.

1997 • 164 citations

The functional significance of epitope spreading and its regulation by co‐stimulatory molecules

1998 • 162 citations

Evolution of the T‐Cell Repertoire during the Course of Experimental Immune‐Mediated Demyelinating Diseases

1995 • 158 citations

A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens

1997 • 158 citations

Demyelination induced by Theiler's virus: influence of the H-2 haplotype.

1985 • 157 citations

The Effect of L3T4 T Cell Depletion on the Pathogenesis of Theiler's Murine Encephalomyelitis Virus Infection in CBA Mice

1987 • 155 citations

Theiler's virus persists in glial cells during demyelinating disease

1981 • 153 citations

Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice.

1984 • 148 citations

Inhibition of murine relapsing experimental autoimmune encephalomyelitis by immune tolerance to proteolipid protein and its encephalitogenic peptides.

1990 • 140 citations

Ultrastructural immunohistochemical localization of virus in acute and chronic demyelinating Theiler's virus infection.

1982 • 139 citations

Demyelinative myelopathy in mice induced by the DA virus

1976 • 139 citations

Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler’s virus–infected mice

1999 • 134 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.

1994 • 128 citations

Variations in genetic control of susceptibility to Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Differences between susceptible SJL/J and resistant BALB/c strains map near the T cell beta-chain constant gene on chromosome 6.

1987 • 127 citations

Persistent Theiler's Murine Encephalomyelitis Virus Infection in Mice depends on Plaque Size

1980 • 121 citations

Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis

1990 • 115 citations

Temporal Development of Autoreactive Th1 Responses and Endogenous Presentation of Self Myelin Epitopes by Central Nervous System-Resident APCs in Theiler’s Virus-Infected Mice

2000 • 113 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease

1990 • 113 citations

Split tolerance of T_hl and T_h2 cells in tolerance to Theiler's murine encephalomyelitis virus

1993 • 107 citations

The Pathogenesis of Postinfectious Myocarditis

1996 • 105 citations

The role of CD8+T cells in the acute and chronic phases of Theiler's murine encephalomyelitis virus-induced disease in mice

1992 • 104 citations

Purification of Theiler's Murine Encephalomyelitis Virus and Analysis of the Structural Virion Polypeptides: Correlation of the Polypeptide Profile with Virulence

1980 • 101 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. V. Mapping of a dominant immunopathologic VP2 T cell epitope in susceptible SJL/J mice.

1994 • 93 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. II. Survey of host immune responses and central nervous system virus titers in inbred mouse strains

1987 • 89 citations

The effect of short-term and chronic immunosuppression on Theiler's virus demyelination

1982 • 88 citations

T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis

1991 • 85 citations

Inhibition of Theiler's virus-mediated demyelination by peripheral immune tolerance induction.

1995 • 82 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. I. Cross-specificity among TMEV substrains and related picornaviruses, but not myelin proteins.

1987 • 81 citations

Anergy in vivo: down-regulation of antigen-specific CD4⁺ T_h1 but not T_h2 cytokine responses

1994 • 79 citations

Cardiac persistence of cardioviral RNA detected by polymerase chain reaction in a murine model of dilated cardiomyopathy.

1992 • 78 citations

Central nervous system chemokine expression during Theiler's virus-induced demyelinating disease

1999 • 74 citations

A predominant viral epitope recognized by T cells from the periphery and demyelinating lesions of SJL/J mice infected with Theiler's virus is located within VP1(233-244).

1994 • 71 citations

Specific immune regulation of chronic-relapsing experimental allergic encephalomyelitis in mice.

1988 • 69 citations

Flow cytometric and functional analyses of central nervous system-infiltrating cells in SJL/J mice with Theiler's virus-induced demyelinating disease. Evidence for a CD4+ T cell-mediated pathology.

1996 • 68 citations

Contrasting effects of immunosuppression on Theiler's virus infection in mice

1977 • 64 citations

Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease

1990 • 60 citations

Immunopathogenesis of multiple sclerosis.

1991 • 58 citations

IgG subclass responses to Theiler's murine encephalomyelitis virus infection and immunization suggest a dominant role for Th1 cells in susceptible mouse strains.

1992 • 57 citations

Persistent anti-myelin basic protein IgG antibody response in multiple sclerosis cerebrospinal fluid

1990 • 56 citations

Schwann cell remyelination and recurrent demyelination in the central nervous system of mice infected with attenuated Theiler's virus.

1980 • 54 citations

Successful treatment of paralytic relapses in adoptive experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance.

1991 • 53 citations

Antigen-driven regulation of experimental autoimmune encephalomyelitis

1998 • 52 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice.

1991 • 49 citations

Immunopathological recognition of autoantigens in multiple sclerosis.

1991 • 48 citations

Characterization of and Functional Antigen Presentation by Central Nervous System Mononuclear Cells from Mice Infected with Theiler’s Murine Encephalomyelitis Virus

1998 • 48 citations

The Theiler's murine encephalomyelitis virus (TMEV) model for multiple sclerosis shows a strong influence of the murine equivalents of HLA-A, B, and C

1987 • 47 citations

BALB/c substrain differences in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease

1994 • 47 citations

Identification of a major T-cell epitope within VP3 amino acid residues 24 to 37 of Theiler's virus in demyelination-susceptible SJL/J mice

1995 • 47 citations

Kinetics and specificity of T and B cell responses in relapsing experimental allergic encephalomyelitis.

1987 • 46 citations

Recurrent demyelination in chronic central nervous system infection produced by Theiler's murine encephalomyelitis virus

1979 • 41 citations

Adoptively transferred CD8+ T lymphocytes provide protection against TMEV-induced demyelinating disease in BALB/c mice.

1996 • 40 citations

Immunologic aspects of Theiler's murine encephalomyelitis virus infection

1990 • 38 citations

Serum and cells from Theiler's virus-infected mice fail to injure myelinating cultures or to produce in vivo transfer of disease

1984 • 37 citations

Current perspectives of neuroimmunologic disease: multiple sclerosis and experimental allergic encephalomyelitis (1,2).

1981 • 36 citations

Induction of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in genetically resistant mice.

1993 • 19 citations

Effects of Irradiation on Development of Theiler's Murine Encephalomyelitis Virus (TMEV)-Induced Demyelinating Disease in Genetically Resistant Mice

1993 • 18 citations