Regulation of Androgen Action

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The nuclear receptor superfamily: The second decade

1995 • 6,929 citations

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

MOLECULAR MECHANISMS OF ACTION OF STEROID/THYROID RECEPTOR SUPERFAMILY MEMBERS

1994 • 2,875 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

ERβ: Identification and characterization of a novel human estrogen receptor

1996 • 2,262 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Male development of chromosomally female mice transgenic for Sry

1991 • 2,157 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

The CBP co-activator is a histone acetyltransferase

1996 • 1,773 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Nuclear Receptor Coactivator ACTR Is a Novel Histone Acetyltransferase and Forms a Multimeric Activation Complex with P/CAF and CBP/p300

1997 • 1,472 citations

Androgen Receptor Defects: Historical, Clinical, and Molecular Perspectives*

1995 • 1,432 citations

Prostate cancer in a transgenic mouse.

1995 • 1,295 citations

Steroid receptor coactivator-1 is a histone acetyltransferase

1997 • 1,245 citations

The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function

1994 • 1,167 citations

Effect of Testosterone and Estradiol in a Man with Aromatase Deficiency

1997 • 1,157 citations

Biological Actions of Androgens

1987 • 1,093 citations

STEROID 5α-REDUCTASE: TWO GENES/TWO ENZYMES

1994 • 1,075 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

The Conversion of Testosterone to 5α-Androstan-17β-ol-3-one by Rat Prostate in Vivo and in Vitro

1968 • 1,023 citations

Cloning of Human Androgen Receptor Complementary DNA and Localization to the X Chromosome

1988 • 1,007 citations

Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor.

1987 • 999 citations

Determinants of target gene specificity for steroid/thyroid hormone receptors

1989 • 954 citations

A mutation in the ligand binding domain of the androgen receptor of human INCaP cells affects steroid binding characteristics and response to anti-androgens

1990 • 948 citations

Role of CBP/P300 in nuclear receptor signalling

1996 • 935 citations

Nuclear receptor coactivators and corepressors.

1996 • 917 citations

Molecular Cloning of Human and Rat Complementary DNA Encoding Androgen Receptors

1988 • 908 citations

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

1995 • 756 citations

Activation of Programmed Cell Death in the Rat Ventral Prostate after Castration*

1988 • 730 citations

Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription.

1994 • 667 citations

Intracrinology

1991 • 654 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells.

1996 • 627 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

Transcriptional activation and nuclear targeting signals of the human androgen receptor.

1991 • 611 citations

Molecular interactions of steroid hormone receptor with its enhancer element: Evidence for receptor dimer formation

1988 • 600 citations

The Human Androgen Receptor: Complementary Deoxyribonucleic Acid Cloning, Sequence Analysis and Gene Expression in Prostate

1988 • 575 citations

Keratinocyte growth factor is required for hair development but not for wound healing.

1996 • 541 citations

Selective Retention of Dihydrotestosterone by Prostatic Nuclei

1968 • 532 citations

Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors.

1988 • 530 citations

Steroid 5α-reductase 2 deficiency

2016 • 527 citations

Long Polyglutamine Tracts in the Androgen Receptor Are Associated with ReducedTrans-Activation, Impaired Sperm Production, and Male Infertility¹

1997 • 519 citations

Domains of the Human Androgen Receptor Involved in Steroid Binding, Transcriptional Activation, and Subcellular Localization

1991 • 513 citations

Characterization and expression of a cDNA encoding the human androgen receptor.

1989 • 483 citations

Cyclic Adenosine 3′,5′-Monophosphate Response Element Binding Protein (CREB) and Related Transcription-Activating Deoxyribonucleic Acid-Binding Proteins*

1993 • 476 citations

Induction of the TRPM-2 gene in cells undergoing programmed death.

1989 • 466 citations

The Promoter of the Prostate-Specific Antigen Gene Contains a Functional Androgen Responsive Element

1991 • 452 citations

Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity.

1989 • 446 citations

Hormone-Induced Morphogenesis and Growth: Role of Mesenchymal–Epithelial Interactions

1983 • 441 citations

Androgen Abuse by Athletes

1988 • 433 citations

Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones.

1992 • 430 citations

Testosterone at High Concentrations Interacts with the Human Androgen Receptor Similarly to Dihydrotestosterone*

1990 • 428 citations

Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens.

1994 • 422 citations

Nuclear receptor coactivators and corepressors

1996 • 414 citations

Transcription Factor Loading on the MMTV Promoter: A Bimodal Mechanism for Promoter Activation

1992 • 411 citations

Molecular Endocrinology of Hydroxysteroid Dehydrogenases*

1997 • 409 citations

Ligand binding was acquired during evolution of nuclear receptors

1997 • 407 citations

Calreticulin

1992 • 402 citations

Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability.

1995 • 393 citations

Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men.

1992 • 391 citations

Hormonal factors in the sex differentiation of the mammalian foetus

1970 • 376 citations

Inhibition of nuclear hormone receptor activity by calreticulin

1994 • 372 citations

Cloning, structure and expression of a cDNA encoding the human androgen receptor

1988 • 371 citations

Interaction between the Amino- and Carboxyl-terminal Regions of the Rat Androgen Receptor Modulates Transcriptional Activity and Is Influenced by Nuclear Receptor Coactivators

1997 • 370 citations

Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene.

1994 • 354 citations

Reduced transcriptional regulatory competence of the androgen receptor in X–linked spinal and bulbar muscular atrophy

1993 • 354 citations

Characterization of response elements for androgens, glucocorticoids and progestins in mouse mammary tumour virus

1988 • 347 citations

Androgen Receptor Antagonist versus Agonist Activities of the Fungicide Vinclozolin Relative to Hydroxyflutamide

1995 • 336 citations

The human androgen receptor: Domain structure, genomic organization and regulation of expression

1989 • 334 citations

Long Polyglutamine Tracts in the Androgen Receptor Are Associated with Reduced Trans-Activation, Impaired Sperm Production, and Male Infertility

1997 • 333 citations

Mechanisms of nuclear localization of the progesterone receptor: Evidence for interaction between monomers

1989 • 329 citations

Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene.

1993 • 319 citations

The Effects of Oral Dehydroepiandrosterone on Endocrine-Metabolic Parameters in Postmenopausal Women*

1990 • 315 citations

Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo.

1995 • 313 citations

Androgen receptor expression in human tissues: an immunohistochemical study.

1991 • 310 citations

A ligand-dependent bipartite nuclear targeting signal in the human androgen receptor. Requirement for the DNA-binding domain and modulation by NH2-terminal and carboxyl-terminal sequences.

1994 • 309 citations

The possible influence of temporal factors in androgenic responsiveness of urogenital tissue recombinants from wild‐type and androgen‐insensitive (Tfm) Mice

1978 • 304 citations

Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism.

1989 • 301 citations

Anatomy of the Steroid Receptor Zinc Finger Region

1992 • 299 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.

1992 • 287 citations

The androgen receptor gene mutations database

1996 • 277 citations

Nuclear import of the human androgen receptor

1993 • 277 citations

The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region.

1987 • 275 citations

Control of Adrenal Androgen Secretion*

1980 • 271 citations

Steroid receptor induction of gene transcription: A two-step model

1997 • 269 citations

Signal Transduction and Transcriptional Regulation by Glucocorticoid Receptor-LexA Fusion Proteins

1988 • 268 citations

A consensus DNA-binding site for the androgen receptor.

1992 • 267 citations

Steroid Structure and Androgenic Activity

1973 • 262 citations

Glucocorticoid-stimulated accumulation of mouse mammary tumor virus RNA: increased rate of synthesis of viral RNA.

1977 • 256 citations

Tissue interaction in androgen response of embryonic mammary rudiment of mouse: identification of target tissue for testosterone.

1976 • 250 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis.

1994 • 248 citations

The prostate gland : morphology and pathobiology

1988 • 246 citations

Transcriptional Regulation of Mammalian Genes in Vivo

1997 • 244 citations

The Androgen Receptor: An Overview

1994 • 224 citations

Identification of Nuclear Factors that Enhance Binding of the Thyroid Hormone Receptor to a Thyroid Hormone Response Element

1989 • 219 citations

Mutual Transcriptional Interference between RelA and Androgen Receptor

1996 • 217 citations

Steroid requirement for androgen receptor dimerization and DNA binding. Modulation by intramolecular interactions between the NH2-terminal and steroid-binding domains.

1993 • 215 citations

Functional in Vivo Interaction between the Amino-Terminal, Transactivation Domain and the Ligand Binding Domain of the Androgen Receptor

1997 • 213 citations

Molecular Endocrinology of Hydroxysteroid Dehydrogenases

1997 • 212 citations

Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men

1992 • 207 citations

Androgenic Induction of Prostate-specific Antigen Gene Is Repressed by Protein-Protein Interaction between the Androgen Receptor and AP-1/c-Jun in the Human Prostate Cancer Cell Line LNCaP

1997 • 203 citations

Steroid 5 alpha-reductase 2 deficiency

1993 • 200 citations

Androgen and Glucocorticoid Receptor Heterodimer Formation

1997 • 194 citations

Androgen increases androgen receptor protein while decreasing receptor mRNA in LNCaP cells

1991 • 192 citations

Molecular genetics and pathophysiology of 17 beta-hydroxysteroid dehydrogenase 3 deficiency

1996 • 188 citations

Inhibition of steroid 5α-reductase by specific aliphatic unsaturated fatty acids

1992 • 188 citations

AN ADRENAL-SECRETED "ANDROGEN": DEHYDROISOANDROSTERONE SULFATE. ITS METABOLISM AND A TENTATIVE GENERALIZATION ON THE METABOLISM OF OTHER STEROID CONJUGATES IN MAN.

1965 • 184 citations

Androgen induction of a human prostate-specific kallikrein, hKLK2: Characterization of an androgen response element in the 5' promoter region of the gene

1993 • 183 citations

Orchiectomy and Nilutamide or Placebo as Treatment of Metastatic Prostatic Cancer in a Multinational Double-Blind Randomized Trial

1993 • 182 citations

Interaction of the human androgen receptor transactivation function with the general transcription factor TFIIF

1997 • 179 citations

Regulation of androgen-dependent prostatic cancer cell growth: androgen regulation of CDK2, CDK4, and CKI p16 genes.

1997 • 174 citations

Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability

1995 • 173 citations

Androgenic Activity of Dehydroepiandrosterone and Androstenedione in the Rat Ventral Prostate

1988 • 167 citations

STRUCTURAL ORGANIZATION OF THE HUMAN ANDROGEN RECEPTOR GENE

1989 • 165 citations

Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator.

1996 • 164 citations

Steroid Sulfotransferases

1996 • 164 citations

Cell proliferation studies in the rat prostate: II. The effects of castration and androgen‐induced regeneration upon basal and secretory cell proliferation

1987 • 164 citations

Estrogenic responses in estrogen receptor-α deficient mice reveal a distinct estrogen signaling pathway

1997 • 164 citations

A and B forms of the androgen receptor are present inhuman genital skin fibroblasts.

1994 • 159 citations

Circulating Concentrations of Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate During Puberty

1975 • 155 citations

Androgen Receptor-Ets Protein Interaction Is a Novel Mechanism for Steroid Hormone-mediated Down-modulation of Matrix Metalloproteinase Expression

1996 • 154 citations

Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen.

1993 • 151 citations

Role of Androgens in Prostatic Cancer

1994 • 149 citations

Nuclear Factor κ B Functions as a Negative Regulator for the Rat Androgen Receptor Gene and NF- κ B Activity Increases during the Age-dependent Desensitization of the Liver

1995 • 148 citations

Molecular Mechanisms of Androgen Action

1994 • 148 citations

A consensus DNA-binding site for the androgen receptor

1992 • 143 citations

Functional Characterizations of the Androgen Receptor Confirm that the Molecular Basis of Androgen Action Is Transcriptional Regulation

1990 • 141 citations

Two different, overlapping pathways of transcription initiation are active on the TATA-less human androgen receptor promoter. The role of Sp1

1993 • 139 citations

Expression of the human androgen receptor gene utilizes a common promoter in diverse human tissues and cell lines.

1990 • 126 citations

Identification of 3',5'-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter.

1994 • 122 citations

Heparin-binding keratinocyte growth factor is a candidate stromal-to- epithelial-cell andromedin

1992 • 121 citations

Anabolic steroids: A review of their effects on the muscles, of their possible mechanisms of action and of their use in athletics

1992 • 120 citations

Response elements of the androgen-regulated C3 gene.

1992 • 119 citations

Transcriptional Up-Regulation of the Human Androgen Receptor by Androgen in Bone Cells*

1997 • 118 citations

Genes regulated by androgen in the rat ventral prostate

1997 • 113 citations

Estrogen sulfotransferase of the rat liver: complementary DNA cloning and age- and sex-specific regulation of messenger RNA.

1992 • 112 citations

Steroid sulfation

1993 • 109 citations

Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens

1994 • 108 citations

Cloning and sequence analysis of a rat liver cDNA encoding hydroxysteroid sulfotransferase

1989 • 107 citations

Regression of mouse mammary gland anlagen in recombinants of Tfm and wild-type tissues: testosterone acts via the mesenchyme

1977 • 105 citations

Changes in the Abundance of Androgen Receptor Isotypes: Effects of Ligand Treatment, Glutamine-Stretch Variation, and Mutation of Putative Phosphorylation Sites

1994 • 105 citations

The role of androgen in the regulation of programmed cell death/apoptosis in normal and malignant prostatic tissue.

1994 • 105 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain

1993 • 105 citations

4-Azasteroidal 5 alpha-reductase inhibitors without affinity for the androgen receptor.

1984 • 104 citations

Characterization of the human androgen receptor transcription unit

1991 • 102 citations

Immunohistochemical Analysis of Androgen Effects on Androgen Receptor Expression in Developing Leydig and Sertoli Cells¹

1997 • 101 citations

Characterization of two cis-acting DNA elements involved in the androgen regulation of the probasin gene

1993 • 101 citations

Molecular cloning and characterization of cDNA for androgen-repressible rat liver protein, SMP-2.

1987 • 100 citations

Oestrogen Sulfotransferase: Molecular Cloning and Sequencing of cDNA for the Bovine Placental Enzyme

1988 • 99 citations

Quantitative determination of prostatic epithelial and stromal hyperplasia by a new technique. Biomorphometrics.

1978 • 97 citations

Estradiol Activates the Prostate Androgen Receptor and Prostate-specific Antigen Secretion through the Intermediacy of Sex Hormone-binding Globulin

1997 • 93 citations

Two androgen response elements in the androgen receptor coding region are required for cell-specific up-regulation of receptor messenger RNA.

1996 • 91 citations

Trinucleotide (GGN) repeat polymorphism in the human androgen receptor (AR) gene

1993 • 90 citations

Regulation of Steroid Hormone Action in Target Cells by Specific Hormone-Inactivating Enzymes

1992 • 89 citations

Human Androgen Receptor Binding to the Androgen Response Element of Prostate Specific Antigen

1994 • 86 citations

Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen

1993 • 85 citations

Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis

1994 • 85 citations

Functional domains of the human androgen receptor

1992 • 83 citations

Essential reproduction

1986 • 82 citations

Induction of translation by the 5'-untranslated region of human androgen receptor mRNA.

1994 • 79 citations

Studies on the Mechanism of 3α-Androstanediol-Induced Growth of the Dog Prostate*

1978 • 78 citations

Relative binding affinities of testosterone, 19-nortestosterone and their 5α-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5α-reductive steroid metabolism in the dissociation of “myotropic” and “androgenic” activities of 19-nortestosterone

1982 • 78 citations

A novel regulatory element associated with age-dependent expression of the rat androgen receptor gene.

1993 • 77 citations

Identification and Characterization of a Novel Androgen Response Element Composed of a Direct Repeat

1997 • 76 citations

Partial characterization of the cytosol 3α-hydroxysteroid:NAD(P)⁺ oxidoreductase of rat ventral prostate

1975 • 73 citations

Anti-Androgenicity of Flutamide and its Metabolite Sch 16423

1979 • 72 citations

Expression of Recombinant Androgen Receptor in Cultured Mammalian Cells

1990 • 72 citations

Molecular basis of human 3β-hydroxysteroid dehydrogenase deficiency

1995 • 72 citations

Growth factors as mediators of androgen action during male urogenital development

1996 • 71 citations

Functional Role of a Conformationally Flexible Homopurine/Homopyrimidine Domain of the Androgen Receptor Gene Promoter Interacting with SP1 and a Pyrimidine Single Strand DNA-Binding Protein

1997 • 70 citations

Localization and hormonal stimulation of phosphorylation sites in the LNCaP-cell androgen receptor

1993 • 67 citations

Role of dihydrotestosterone in androgen action

1996 • 67 citations

Androgen receptors: Structures, mutations, antibodies and cellular dynamics

1989 • 64 citations

Steroid hormone receptors in the adrenal glands of fetal and adult rhesus monkeys.

1992 • 63 citations

Tissue-specific and Androgen-repressible Regulation of the Rat Dehydroepiandrosterone Sulfotransferase Gene Promoter

1998 • 62 citations

A complex response element in intron 1 of the androgen-regulated 20-kDa protein gene displays cell type-dependent androgen receptor specificity.

1993 • 59 citations

Müllerian Inhibiting Substance: Gene Structure and Mechanism of Action of a Fetal Regressor

1987 • 59 citations

Interaction of androgen response elements with the DNA-binding domain of the rat androgen receptor expressed in Escherichia coli

1991 • 57 citations

Mutations in the Hormone Regulatory Element of Mouse Mammary Tumor Virus Differentially Affect the Response to Progestins, Androgens, and Glucocorticoids

1989 • 57 citations

Distribution of Aromatase Cytochrome P450 Messenger Ribonucleic Acid in Adult Rhesus Monkey Brains1

1997 • 57 citations

C₁₉and C₂₁5β/5αMetabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency*

1990 • 57 citations

Transcriptional Repression of the α-Subunit Gene by Androgen Receptor Occurs Independently of DNA Binding but Requires the DNA-Binding and Ligand-Binding Domains of the Receptor

1997 • 56 citations

Androgen Action

1995 • 56 citations

Transient down-regulation of androgen receptor messenger ribonucleic acid (mRNA) expression in Sertoli cells by follicle-stimulating hormone is followed by up-regulation of androgen receptor mRNA and protein.

1992 • 55 citations

The mouse androgen receptor. Functional analysis of the protein and characterization of the gene

1991 • 54 citations

Enzymatic modulation of hormonal action at the target tissue

1978 • 53 citations

Stable transfection of androgen receptor and MMTV-CAT into mammalian cells: Inhibition of cat expression by anti-androgens

1992 • 53 citations

Anti-Müllerian hormone and intersex states

1991 • 52 citations

Regulation of the 5'-flanking region of the mouse androgen receptor gene by cAMP and androgen.

1993 • 51 citations

Identification of 3',5'-cyclic adenosine monophosphate response element and other cis-acting elements in the human androgen receptor gene promoter

1994 • 51 citations

Expression of clusterin in cell differentiation and cell death

1994 • 51 citations

The rat androgen receptor gene promoter

1990 • 51 citations

Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator

1996 • 50 citations

Analysis of androgen receptor-DNA interactions with receptor proteins produced in insect cells

1994 • 49 citations

Regulation of Androgen Receptor mRNA in Rat Sertoli and Peritubular Cells1

1991 • 48 citations

Estrogen sulfotransferase of the rat liver: complementary DNA cloning and age- and sex-specific regulation of messenger RNA

1992 • 46 citations

Control of tumor progression by maintenance of apoptosis

1996 • 45 citations

STUDIES ON THE AROMATIZATION OF C‐19 ANDROGENS*

1973 • 45 citations

Androgen Regulation of the Rat Keratinocyte Growth Factor (KGF/FGF7) Promoter

1996 • 44 citations

The androgen receptor gene mutations database

1997 • 42 citations

Dimerization characteristics of the DNA- and steroid-binding domains of the androgen receptor

1994 • 41 citations

The Dynamics of the Transcriptional Response to Cyclic Adenosine 3′,5′-Monophosphate: Recurrent Inducibility and Refractory Phase

1997 • 40 citations

Tissue-Specific and Hormonal Regulation of the Gene for Rat Prostatic Steroid-Binding Protein in Transgenic Mice

1989 • 40 citations

CONVERSION OF DESOXYCORTICOSTERONE TO FOUR ALLOPREGNANE METABOLITES BY RAT LIVER IN VITRO

1952 • 40 citations

Human dehydroepiandrosterone sulfotransferase pharmacogenetics: Quantitative Western analysis and gene sequence polymorphisms

1996 • 40 citations

Domain functions of the androgen receptor

1992 • 40 citations

Two androgen response elements in the androgen receptor coding region are required for cell-specific up-regulation of receptor messenger RNA

1996 • 40 citations

Transcriptional Up-Regulation of the Human Androgen Receptor by Androgen in Bone Cells

1997 • 39 citations

Cloning and Characterization of the Promoter Region of the Human Keratinocyte Growth Factor Gene

1995 • 39 citations

Mutations in the hormone regulatory element of mouse mammary tumor virus differentially affect the response to progestins, androgens, and glucocorticoids.

1989 • 37 citations

Identification and characterization of a suppressor element in the 5′-flanking region of the mouse androgen receptor gene

1994 • 37 citations

Immunohistochemical Analysis of Androgen Effects on Androgen Receptor Expression in Developing Leydig and Sertoli Cells

1997 • 36 citations

The Androgen Receptor Is Transcriptionally Suppressed by Proteins That Bind Single-stranded DNA

1995 • 36 citations

Changes in dihydrotestosterone metabolism and the development of benign prostatic hyperplasia in the aging beagle

1983 • 36 citations

Steroid hormone receptors in the adrenal glands of fetal and adult rhesus monkeys

1992 • 33 citations

Regulation of immunoreactive androgen receptor in the adrenal gland of the adult rat.

1996 • 33 citations

A distal activation domain is critical in the regulation of the rat androgen receptor gene promoter

1993 • 31 citations

Programmed cell death as a new target for prostatic cancer therapy.

1991 • 30 citations

Regulation of steroid glucuronosyltransferase activities and transcripts by androgen in the human prostatic cancer LNCaP cell line.

1996 • 30 citations

Relation of the Testis to Adrenal Enzyme Activity and Adrenal Corticosterone Production in the Rat

1966 • 30 citations

Role of Transcription Factors in the Age-Dependent Regulation of the Androgen Receptor Gene in Rat Liver

1996 • 29 citations

Prostate Cancer: Cell and Molecular Mechanisms in Diagnosis and Treatment

1991 • 29 citations

Targeted overexpression of androgen receptor with a liver-specific promoter in transgenic mice.

1996 • 29 citations

The Mouse Androgen Receptor Gene Contains a Second Functional Promoter Which Is Regulated by Dihydrotestosterone

1994 • 29 citations

Functional Role of a Conformationally Flexible Homopurine/Homopyrimidine Domain of the Androgen Receptor Gene Promoter Interacting with SP1 and a Pyrimidine Single Strand DNA-Binding Protein

1997 • 26 citations

At the cutting edge can a single androgen receptor fill the bill?

1991 • 26 citations

Tissue-specific and hormonal regulation of the gene for rat prostatic steroid-binding protein in transgenic mice.

1989 • 25 citations

Androgen and estrogen sulfotransferases of the rat liver: physiological function, molecular cloning, and in vitro expression

1994 • 25 citations

Spatio-temporal expression of estrogen sulfotransferase within the hepatic lobule of male rats: implication of in situ estrogen inactivation in androgen action.

1992 • 24 citations

ZR-75-1 breast cancer cells generate nonconjugated steroids from low density lipoprotein-incorporated lipoidal dehydroepiandrosterone.

1993 • 23 citations

Studies on the mechanism of action of win 49596: A steroidal androgen receptor antagonist

1989 • 23 citations

Specific steroid response from a nonspecific DNA element

1994 • 21 citations

Regulation of the 5'-flanking region of the mouse androgen receptor gene by cAMP and androgen

1993 • 20 citations

Transient down-regulation of androgen receptor messenger ribonucleic acid (mRNA) expression in Sertoli cells by follicle-stimulating hormone is followed by up-regulation of androgen receptor mRNA and protein

1992 • 19 citations

The Dynamics of the Transcriptional Response to Cyclic Adenosine 3',5'-Monophosphate: Recurrent Inducibility and Refractory Phase

1997 • 19 citations

Regulation of immunoreactive androgen receptor in the adrenal gland of the adult rat

1996 • 18 citations

Androgen glucuronyl transferase activity in rat liver, evidence for the importance of hepatic tissue in 5 α-reduced androgen metabolism

1989 • 18 citations

Analysis of the promoter of the human prostatic acid phosphatase gene

1994 • 17 citations

Effects of Androgens and Antiandrogens on the Conformation of the Androgen Receptor

1995 • 16 citations

Transcriptional Repression of the -Subunit Gene by Androgen Receptor Occurs Independently of DNA Binding but Requires the DNA-Binding and Ligand-Binding Domains of the Receptor

1997 • 16 citations

Casodex: Preclinical Studies and Controversiesa

1995 • 15 citations

Inhibition of androgen action by dehydroepiandrosterone sulfotransferase transfected in PC-3 prostate cancer cells

1998 • 15 citations

Spatio-temporal expression of estrogen sulfotransferase within the hepatic lobule of male rats: implication of in situ estrogen inactivation in androgen action

1992 • 14 citations

Autoregulation of androgen receptor in rat ventral prostate: involvement of c-fos as a negative regulator

1996 • 12 citations

Effects of dihydrotestosterone treatment on adrenal gland function and morphology in adult female guinea-pigs

1990 • 11 citations

Regulation of steroid glucuronosyltransferase activities and transcripts by androgen in the human prostatic cancer LNCaP cell line

1996 • 11 citations

ZR-75-1 breast cancer cells generate nonconjugated steroids from low density lipoprotein-incorporated lipoidal dehydroepiandrosterone

1993 • 10 citations

Phosphorylation and nuclear processing of the androgen receptor

1990 • 10 citations

Age-dependent reversal of the lobular distribution of androgen-inducible alpha 2u globulin and androgen-repressible SMP-2 in rat liver.

1991 • 10 citations

Functional Androgen Response Elements in the Genes Coding for Prostatic Binding Protein^a

1993 • 8 citations

Benign prostatic hyperplasia: dihydrotestosterone and 5 alpha-reductase inhibition therapy.

1994 • 5 citations