TGF-β Promotes Immune Deviation by Altering Accessory Signals of Antigen-Presenting Cells

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

1990 • 1,897 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

1992 • 818 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Natural killer (NK) cell stimulatory factor or IL-12 has differential effects on the proliferation of TCR-alpha beta+, TCR-gamma delta+ T lymphocytes, and NK cells.

1992 • 333 citations

Regulation of human cytolytic lymphocyte responses by interleukin-12

1992 • 331 citations

Immunoregulation by interleukin-12

1996 • 298 citations

T helper type 1 development of naive CD4⁺ T cells requires the coordinate action of interleukin‐12 and interferon‐γ and is inhibited by transforming growth factor‐β

1994 • 288 citations

Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2.

1992 • 284 citations

Immune Privilege and Immune Regulation in the Eye

1990 • 265 citations

Transforming growth factor-beta and IL-4 cause helper T cell precursors to develop into distinct effector helper cells that differ in lymphokine secretion pattern and cell surface phenotype.

1991 • 254 citations

Studies on the induction of anterior chamber‐associated immune deviation (ACAID) III. Induction of ACAID depends upon intraocular transforming growth factor‐β

1992 • 250 citations

Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation.

1990 • 234 citations

Immune regulation and the eye: a dangerous compromise

1987 • 217 citations

Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction.

1996 • 197 citations

CD40/CD40 ligand interactions are required for T cell‐dependent production of interleukin‐12 by mouse macrophages

1996 • 184 citations

Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression.

1990 • 159 citations

Differential susceptibility of activated macrophage cytotoxic effector reactions to the suppressive effects of transforming growth factor-beta 1.

1991 • 147 citations

Systemic immune unresponsiveness induced in adult mice by anterior chamber presentation of minor histocompatibility antigens.

1980 • 139 citations

Effect of transforming growth factor-beta on early and late activation events in human T cells.

1993 • 137 citations

Differential effect of transforming growth factor β on the synthesis of T_h1‐ and T_h2‐like lymphokines by human T lymphocytes

1992 • 131 citations

On the mechanisms by which transforming growth factor‐β2 alters antigen‐presenting abilities of macrophages on T cell activation

1997 • 121 citations

Production of macrophage colony-stimulating factor by astrocytes and brain macrophages

1992 • 84 citations

Memory T cell development in the absence of specific antigen priming.

1996 • 83 citations

Role of Th1 and Th2 cells in anterior chamber‐associated immune deviation

1996 • 78 citations

Differential expression of mRNA encoding interleukin‐12 p35 and p40 subunits in situ

1994 • 77 citations

Mechanistic studies of transforming growth factor-beta inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions. Regulation of IL-2R beta (p75) signal transduction.

1991 • 75 citations

Direct thymic involvement in anterior chamber-associated immune deviation: evidence for a nondeletional mechanism of centrally induced tolerance to extrathymic antigens in adult mice.

1997 • 70 citations

Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen-presenting cell.

1993 • 62 citations

Influence of TGF-beta on murine thymocyte development in fetal thymus organ culture.

1995 • 49 citations

Role of splenic B cells in the immune privilege of the anterior chamber of the eye

1995 • 38 citations

Characterization of specific T helper cell activity in mice bearing alloantigenic tumors in the anterior chamber of the eye

1991 • 19 citations