Infection breaks T-cell tolerance

A Cell Culture Model for T Lymphocyte Clonal Anergy

1990 • 1,894 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity

1990 • 904 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1991 • 675 citations

Autoimmune Diseases: The Failure of Self Tolerance

1990 • 495 citations

Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells

1989 • 462 citations

In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B.

1990 • 370 citations

TH2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity

1991 • 365 citations

Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1.

1986 • 355 citations

Induction of classical transplantation tolerance in the adult.

1989 • 325 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S).

1989 • 289 citations

T-cell tolerance by clonal anergy in transgenic mice with nonlymphoid expression of MHC class II I–E

1989 • 238 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production.

1990 • 155 citations

T Cell Reactivity to MHC Molecules: Immunity Versus Tolerance

1990 • 148 citations

Neonatal Thymectomy Results in a Repertoire Enriched in T Cells Deleted in Adult Thymus

1989 • 146 citations

Thymic Requirement for Clonal Deletion During T Cell Development

1989 • 95 citations

Peripheral tolerance to allogeneic class II histocompatibility antigens expressed in transgenic mice: evidence against a clonal-deletion mechanism.

1989 • 91 citations

Failure of T Cell Receptor V _β Negative Selection in an Athymic Environment

1989 • 76 citations

Central role for TCR/CD3 ligation in the differentiation of CD4+ T cells toward A Th1 or Th2 functional phenotype.

1992 • 69 citations

Distinct fates of self-specific T cells developing in irradiation bone marrow chimeras: clonal deletion, clonal anergy, or in vitro responsiveness to self-Mls-1a controlled by hemopoietic cells in the thymus.

1990 • 54 citations

Self-reactive T cells can escape clonal deletion in T-cell receptor V beta 8.1 transgenic mice.

1990 • 41 citations