Regional specialization of the mucosal immune system. Intraepithelial lymphocytes of the large intestine have a different phenotype and function than those of the small intestine.

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1.5: similarity of L3T4 to the human Leu-3/T4 molecule.

1983 • 1,307 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Expression of the γ-δ T-cell receptor on intestinal CD8+ intraepithelial lymphocytes

1988 • 663 citations

T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views.

1980 • 574 citations

Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells

1988 • 394 citations

Identification of Macrophage-Like Characteristics in a Cultured Murine Tumor Line

1975 • 374 citations

Establishment of Monoclonal Anti-Nk-1.1 Antibody

1984 • 360 citations

Intraepithelial lymphocytes. Anatomical site, not T cell receptor form, dictates phenotype and function.

1989 • 356 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

The Biologic Roles of CD2, CD4, and CD8 in T-Cell Activation

1989 • 301 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

In Vivo Modulation of Cytolytic Activity and Thy-1 Expression In TCR-γδ ⁺ Intraepithelial Lymphocytes

1989 • 258 citations

A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines

1989 • 237 citations

Expression of Murine CD1 on Gastrointestinal Epithelium

1990 • 231 citations

Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.

1990 • 226 citations

Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine.

1981 • 222 citations

The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells.

1984 • 214 citations

Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules.

1991 • 183 citations

Expression of the thymus leukemia antigen in mouse intestinal epithelium.

1990 • 161 citations

Monoclonal antibodies specific for murine CD2 reveal its presence on B as well as T cells.

1989 • 118 citations

Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals.

1993 • 117 citations

Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire?

1991 • 114 citations

Leukocytes in the intestinal epithelium: an unusual immunological compartment

1985 • 113 citations

ANALYSIS OF THE EFFECTOR FUNCTIONS OF DIFFERENT POPULATIONS OF MUCOSAL LYMPHOCYTES*

1983 • 107 citations

Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium.

1991 • 93 citations

A unique surface antigen on intraepithelial lymphocytes in the mouse

1988 • 78 citations

Proliferative properties of murine intestinal intraepithelial lymphocytes (IEL): IEL expressing TCRαβ or TCRτδ are largely unresponsive to proliferative signals mediated via conventional stimulation of the CD3-TCR complex

1991 • 61 citations

Intraepithelial lymphocytes of the intestinal mucosa: curiouser and curiouser.

1991 • 54 citations

Intestinal intraepithelial lymphocytes and lymphoepithelial interactions in the human gastrointestinal mucosa

1992 • 39 citations

The thymus leukemia antigen binds human and mouse CD8.

1991 • 39 citations

Characterization of proximal colonic lymphoid tissue in the mouse

1988 • 22 citations