Electrophysiological Pharmacology of Mesencephalic Dopaminergic Neurons

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

The rat nervous system

1985 • 3,774 citations

Multiple receptors for dopamine

1979 • 3,739 citations

FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE

1962 • 2,684 citations

Drug Abuse: Hedonic Homeostatic Dysregulation

1997 • 2,472 citations

Effect of Chlorpromazine or Haloperidol on Formation of 3‐Methoxytyramine and Normetanephrine in Mouse Brain

1963 • 2,148 citations

Cellular and Molecular Mechanisms of Drug Dependence

1988 • 2,094 citations

Molecular basis of long-term plasticity underlying addiction

2001 • 1,831 citations

Opioids excite dopamine neurons by hyperpolarization of local interneurons

1992 • 1,585 citations

The control of firing pattern in nigral dopamine neurons: burst firing

1984 • 1,326 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex

1989 • 1,107 citations

Psychopharmacology: A Generation of Progress

1979 • 1,101 citations

Molecular mechanisms of drug addiction

2004 • 1,080 citations

Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ ₁ Opioid Receptor Mechanism

1997 • 1,078 citations

Molecular biology of dopamine receptors

1992 • 998 citations

Modulation of neurotransmitter release by presynaptic autoreceptors

1989 • 935 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization

1983 • 925 citations

Substance Abuse: A Comprehensive Textbook

1992 • 890 citations

Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines

1984 • 866 citations

The control of firing pattern in nigral dopamine neurons: single spike firing

1984 • 856 citations

Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area

1992 • 832 citations

Demonstration and mapping out of nigro-neostriatal dopamine neurons

1964 • 796 citations

Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

1985 • 788 citations

The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems

1987 • 788 citations

Nicotine activates and desensitizes midbrain dopamine neurons

1997 • 762 citations

Coordinated Expression of Dopamine Receptors in Neostriatal Medium Spiny Neurons

1996 • 743 citations

Dendritic release of dopamine in the substantia nigra

1981 • 732 citations

Substance Abuse: A Comprehensive Textbook

1998 • 721 citations

Neurotransmitter regulation of dopamine neurons in the ventral tegmental area

1993 • 713 citations

Distinct functions of the two isoforms of dopamine D2 receptors

2000 • 706 citations

Stimulants : neurochemical, behavioral, and clinical perspectives

1983 • 689 citations

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

1988 • 663 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

Release of dopamine from dendrites in rat substantia nigra

1976 • 644 citations

On the Presence of 3-Hydroxytyramine in Brain

1958 • 632 citations

Localization of monoamines in the lower brain stem

1964 • 628 citations

Dopamine acts on D2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta.

1987 • 611 citations

Differential Effects of Classical and Atypical Antipsychotic Drugs on A9 and A10 Dopamine Neurons

1983 • 589 citations

Efferent projections of the subthalamic nucleus in the rat: Light and electron microscopic analysis with the PHA‐L method

1987 • 580 citations

Afferent projections to the ventral tegmental area of Tsai and interfascicular nucleus: A horseradish peroxidase study in the rat

1979 • 550 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Dopamine ?Autoreceptors?: Pharmacological characterization by microiontophoretic single cell recording studies

1977 • 544 citations

Pedunculopontine tegmental nucleus of the rat: Cytoarchitecture, cytochemistry, and some extrapyramidal connections of the mesopontine tegmentum

1987 • 537 citations

Neuronal localization of cannabinoid receptors in the basal ganglia of the rat

1991 • 515 citations

Dopamine Auto- and Postsynaptic Receptors: Electrophysiological Evidence for Differential Sensitivity to Dopamine Agonists

1979 • 502 citations

Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra

1978 • 498 citations

The Neurobiology of Dopamine

1980 • 496 citations

Morphine-induced activation of A10 dopamine neurons in the rat

1983 • 485 citations

Dopamine in dendrites of substantia nigra neurons: suggestions for a role in dendritic terminals

1975 • 482 citations

Burst firing in midbrain dopaminergic neurons

1997 • 482 citations

Molecular Neurobiology of the Mammalian Brain

1987 • 481 citations

Ultrastructural localization of D2 receptor-like immunoreactivity in midbrain dopamine neurons and their striatal targets

1994 • 454 citations

Drug‐Induced Changes in the Release of ³H‐Monoamines from Field Stimulated Rat Brain Slices

1971 • 453 citations

Frontiers in Catecholamine Research

1976 • 451 citations

Comparison of Effects of L-Dopa, Amphetamine and Apomorphine on Firing Rate of Rat Dopaminergic Neurones

1973 • 436 citations

Burst Firing in Dopamine Neurons Induced by N -Methyl-D-aspartate: Role of Electrogenic Sodium Pump

1992 • 433 citations

Dopamine receptor subtypes colocalize in rat striatonigral neurons.

1992 • 428 citations

Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids

1989 • 426 citations

Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine

1984 • 424 citations

The physiology of nerve cells

1975 • 410 citations

Nicotinic effects on the firing pattern of midbrain dopamine neurons

1986 • 399 citations

Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons

1979 • 393 citations

Molecular mechanisms of drug addiction [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]

1992 • 392 citations

Ethanol Directly Excites Dopaminergic Ventral Tegmental Area Reward Neurons

1999 • 390 citations

Blockage of caudate-evoked inhibition of neurons in the substantia nigra by picrotoxin

1971 • 387 citations

The interpretation of spike potentials of motoneurones

1957 • 381 citations

The afferent and efferent connections of the feline nucleus tegmenti pedunculopontinus, pars compacta

1983 • 380 citations

The Physiology of Nerve Cells

1957 • 380 citations

Serotonin axon terminals in the ventral tegmental area of the rat: fine structure and synaptic input to dopaminergic neurons

1987 • 374 citations

Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra

1997 • 366 citations

Advances in Neurology. Vol. 2

1974 • 364 citations

Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors

1998 • 363 citations

GABAA receptor-mediated inhibition of rat substantia nigra dopaminergic neurons by pars reticulata projection neurons

1995 • 356 citations

Tonic Activation of NMDA Receptors Causes Spontaneous Burst Discharge of Rat Midbrain Dopamine Neurons In Vivo

1993 • 350 citations

Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors

1976 • 350 citations

Monosynaptic inhibition of neurons of the substantia nigra by caudatonigral fibers

1971 • 344 citations

Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data

1990 • 343 citations

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.

1988 • 336 citations

Dopamine modulates S-potential amplitude and dye-coupling between external horizontal cells in carp retina

1983 • 333 citations

Ultrastructural immunocytochemical localization of tyrosine hydroxylase in the neostriatum

1981 • 332 citations

Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons

1981 • 321 citations

Dopamine D₃Receptors Expressed by All Mesencephalic Dopamine Neurons

2000 • 320 citations

Mechanisms of action of atypical antipsychotic drugs: a critical analysis

1996 • 315 citations

Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: studies in the ventral tegmental area

1988 • 313 citations

Mechanisms of signal transduction at the dopamine D2 receptor

1989 • 312 citations

Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons

1984 • 312 citations

Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: analysis using in vivo intracellular recording.

1986 • 309 citations

Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence.

1993 • 308 citations

Molecular determinants of metabotropic glutamate receptor signaling

2001 • 307 citations

Prolonged and Extrasynaptic Excitatory Action of Dopamine Mediated by D1 Receptors in the Rat StriatumIn Vivo

1997 • 303 citations

Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons

1995 • 292 citations

Noradrenergic modulation of midbrain dopamine cell firing elicited by stimulation of the locus coeruleus in the rat

1993 • 292 citations

Nicotinic excitation of rat ventral tegmental neurones in vitro studied by intracellular recording

1989 • 291 citations

Synaptic Regulation of Mesocorticolimbic Dopamine Neurons

1996 • 289 citations

Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons

1998 • 285 citations

Electrophysiological properties of identified output neurons of the rat substantia nigra (pars compacta and pars reticulata): Evidences for the existence of branched neurons

1978 • 284 citations

Dopamine-cell depolarization block as a model for the therapeutic actions of antipsychotic drugs

1997 • 284 citations

Burst firing induced in midbrain dopamine neurons by stimulation of the medial prefrontal and anterior cingulate cortices

1988 • 281 citations

Evidence for the existence of a raphe projection to the substantia nigra in rat

1976 • 280 citations

Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity

1985 • 279 citations

Increased Probability of GABA Release during Withdrawal from Morphine

1997 • 279 citations

Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons.

1996 • 276 citations

Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine

1987 • 275 citations

Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: repeated administration.

1989 • 273 citations

Immunocytochemical localization of glutamate decarboxylase in rat substantia nigra

1976 • 272 citations

Coupled Oscillator Model of the Dopaminergic Neuron of the Substantia Nigra

2000 • 267 citations

Distribution of D2 dopamine receptor mRNA in rat brain.

1989 • 263 citations

Dopamine D1 receptors facilitate transmitter release

1993 • 260 citations

The substantia nigra of the rat: A golgi study

1977 • 258 citations

Electrophysiology of dopaminergic and non‐dopaminergic neurones of the guinea‐pig substantia nigra pars compacta in vitro.

1991 • 257 citations

The GABA and substance P input to dopaminergic neurones in the substantia nigra of the rat

1990 • 254 citations

Loss of autoreceptor functions in mice lacking the dopamine transporter

1999 • 253 citations

Distribution of alpha 1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes

1994 • 245 citations

Intracellular study of rat substantia nigra pars reticulata neurons in an in vitro slice preparation: electrical membrane properties and response characteristics to subthalamic stimulation

1987 • 243 citations

Dopaminergic neurons in the rat ventral tegmental area. I. Identification and characterization

1981 • 242 citations

Regulation of monoamine metabolism in the central nervous system.

1972 • 241 citations

Alterations in Dopamine Release But Not Dopamine Autoreceptor Function in Dopamine D₃Receptor Mutant Mice

1998 • 239 citations

Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence

1980 • 239 citations

Anatomy of brain alpha₁‐adrenergic receptors: In vitro autoradiography with [¹²⁵I]‐heat

1985 • 238 citations

Firing properties of substantia nigra dopaminergic neurons in freely moving rats

1985 • 235 citations

Afferent modulation of dopamine neuron firing patterns

1999 • 232 citations

Stimulation of nigrostriatal dopamine neurones by nicotine

1982 • 232 citations

Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity

1992 • 231 citations

Glutamatergic and cholinergic inputs from the pedunculopontine tegmental nucleus to dopamine neurons in the substantia nigra pars compacta

1995 • 230 citations

CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut.

1973 • 230 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—2. Action potential generating mechanisms and morphological correlates

1983 • 227 citations

Δ9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors

1997 • 227 citations

Electrophysiology of pars compacta cells in the in vitro substantia nigra—a possible mechanism for dendritic release

1984 • 226 citations

The cortico-nigral projection in the rat: an anterograde tracing study with biotinylated dextran amine

1994 • 221 citations

Synaptic inputs to GABAA and GABAB receptors originate from discrete afferent neurons

1992 • 220 citations

Iontophoretically administered drugs acting at the N‐methyl‐D‐aspartate receptor modulate burst firing in A9 dopamine neurons in the rat

1992 • 219 citations

Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome

1994 • 214 citations

Nifedipine‐ and omega‐conotoxin‐sensitive Ca2+ conductances in guinea‐pig substantia nigra pars compacta neurones.

1993 • 213 citations

An anatomical and electrophysiological investigation of the serotonergic projection from the dorsal raphe nucleus to the substantia nigra in the rat

1977 • 210 citations

Increased responsiveness of ventral tegmental area dopamine neurons to glutamate after repeated administration of cocaine or amphetamine is transient and selectively involves AMPA receptors.

1997 • 210 citations

Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats

1984 • 208 citations

Demonstration of a pallido‐nigral projection innervating dopaminergic neurons

1975 • 207 citations

Characterization of G-Protein-Gated K⁺Channels Composed of Kir3.2 Subunits in Dopaminergic Neurons of the Substantia Nigra

1999 • 205 citations

Correspondence

1997 • 204 citations

Monosynaptic input from the nucleus accumbens-ventral striatum region to retrogradely labelled nigrostriatal neurones

1981 • 204 citations

Neurons of the substantia nigra reticulata receive a dense GABA-containing input from the globus pallidus in the rat

1989 • 200 citations

Marijuana's interaction with brain reward systems: Update 1991

1991 • 199 citations

Chemical neurotransmission 75 Years

1982 • 199 citations

Collateralization of monoamine neurons: mesotelencephalic dopamine projections to caudate, septum, and frontal cortex

1981 • 199 citations

Morphology of the substantia nigra pars reticulata projection neurons intracellularly labeled with HRP

1982 • 198 citations

An experimental electron microscopic study on the striatonigral projection in the cat

1970 • 198 citations

Innervation of substantia nigra neurons by cholinergic afferents from pedunculopontine nucleus in the rat: neuroanatomical and electrophysiological evidence

1987 • 194 citations

The Neurobiology of dopamine

1979 • 193 citations

Dopaminergic dendrites in the pars reticulata of the rat substantia nigra and their striatal input. combined immunocytochemical localization of tyrosine hydroxylase and anterograde degeneration

1981 • 192 citations

Mesolimbic dopaminergic decline after cannabinoid withdrawal

1998 • 189 citations

Electrical membrane properties of rat substantia nigra compacta neurons in an in vitro slice preparation

1986 • 187 citations

Stimulation of the prefrontal cortex in the rat induces patterns of activity in midbrain dopaminergic neurons which resemble natural burst events

1996 • 187 citations

Electrophysiological demonstration of an excitatory subthalamonigral pathway in the rat

1978 • 181 citations

Mapping out of catecholamine and 5-hydroxytryptamine neurons innervating the telencephalon and diencephalon

1965 • 173 citations

Enhanced Cortical Dopamine Output and Antipsychotic-like Effects of Raclopride by α ₂ Adrenoceptor Blockade

1999 • 171 citations

Cholinergic projections to the substantia nigra from the pedunculopontine and laterodorsal tegmental nuclei

1989 • 171 citations

Physical withdrawal in rats tolerant to Δ9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist

1995 • 170 citations

Serotonergic afferent regulation of the basic physiology and pharmacological responsiveness of nigrostriatal dopamine neurons.

1990 • 170 citations

Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats.

1995 • 167 citations

Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra

1988 • 165 citations

Neurophysiology of Dopaminergic Systems: Current Status and Clinical Perspectives

1987 • 165 citations

Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin

1987 • 164 citations

Statistical properties of neuronal spike trains in the substantia nigra: Cell types and their interactions

1977 • 163 citations

Apamin-sensitive Ca2+-activated K+ channels regulate pacemaker activity in nigral dopamine neurons

1996 • 160 citations

Autoreceptor Regulation of Dopamine Synthesis

1990 • 160 citations

Gabaergic nerve terminals decrease in the substantia nigra following hemitransections of the striatonigral and pallidonigral pathways

1980 • 159 citations

Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.

1996 • 158 citations

Organization and efferent projections of nucleus tegmenti pedunculopontinus pars compacta with special reference to its cholinergic aspects

1984 • 157 citations

Electroconvulsive Shock: Progressive Dopamine Autoreceptor Subsensitivity Independent of Repeated Treatment

1980 • 155 citations

Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect?

1985 • 155 citations

Presynaptic Regulation of Glutamate Release in the Ventral Tegmental Area During Morphine Withdrawal

1999 • 152 citations

Local cooling of pre‐frontal cortex induces pacemaker‐like firing of dopamine neurons in rat ventral tegmental area in vivo

1989 • 151 citations

The primate substantia nigra: a Golgi and electron microscopic study.

1974 • 149 citations

Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons.

1977 • 149 citations

Cholinergic and noncholinergic tegmental pedunculopontine projection neurons in rats revealed by intracellular labeling

1996 • 147 citations

GABAA and GABAB antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo

1999 • 147 citations

Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABAA receptors in vivo

1999 • 145 citations

Glutamate receptor subtypes mediate excitatory synaptic currents of dopamine neurons in midbrain slices

1991 • 145 citations

Voltage-dependent calcium channels in rat midbrain dopamine neurons: modulation by dopamine and GABAB receptors

1995 • 145 citations

Functional roles of dopamine D2 and D3 autoreceptors on nigrostriatal neurons analyzed by antisense knockdown in vivo.

1997 • 144 citations

Presynaptic modulation of the release of dopamine from the rabbit caudate nucleus: differences between electrical stimulation, amphetamine and tyramine.

1981 • 144 citations

In Vivo Assessment of Dopamine Uptake in Rat Medial Prefrontal Cortex: Comparison with Dorsal Striatum and Nucleus Accumbens

1995 • 143 citations

Differential Actions of Serotonin, Mediated by 5-HT_1Band 5-HT_2CReceptors, on GABA-Mediated Synaptic Input to Rat Substantia Nigra Pars Reticulata NeuronsIn Vitro

1996 • 143 citations

The Effects of Ethanol on Dopaminergic Neurons of the Ventral Tegmental Area Studied with Intracellular Recording in Brain Slices

1998 • 143 citations

Selective localization of striatal D1 receptors to striatonigral neurons

1990 • 143 citations

Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex

1990 • 142 citations

Electrophysiologically identified nigral dopaminergic neurons intracellularly labeled with HRP: light-microscopic analysis

1987 • 140 citations

Gabaergic control of rat substantia nigra dopaminergic neurons: role of globus pallidus and substantia nigra pars reticulata

1999 • 139 citations

Cellular responses to chronic treatment with drugs of abuse.

1993 • 138 citations

Neuronal interactions in the substantia nigra pars reticulata through axon collaterals of the projection neurons

1982 • 134 citations

The release of endogenous norepinephrine and dopamine from cerebral cortex by amphetamine.

1977 • 134 citations

Mesocortical dopamine neurons: rapid transmitter turnover compared to other brain catecholamine systems.

1981 • 131 citations

Mesolimbic dopaminergic reduction outlasts ethanol withdrawal syndrome: Evidence of protracted abstinence

1996 • 131 citations

Electrophysiological effects of MK-801 on rat nigrostriatal and mesoaccumbal dopaminergic neurons

1992 • 130 citations

Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids

1998 • 130 citations

Quantitative autoradiographic mapping of rat brain dopamine D3 binding with [(125)I]7-OH-PIPAT: evidence for the presence of D3 receptors on dopaminergic and nondopaminergic cell bodies and terminals.

2000 • 129 citations

Calcium spike underlying rhythmic firing in dopaminergic neurons of the rat substantia nigra

1993 • 128 citations

Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal

1999 • 126 citations

Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A

1995 • 126 citations

Stimulation of the pedunculopontine tegmental nucleus in the rat produces burst firing in A9 dopaminergic neurons

1999 • 126 citations

Actions of cocaine on rat dopaminergic neurones in vitro

1990 • 126 citations

Clonidine modulates dopamine cell firing in rat ventral tegmental area

1989 • 126 citations

A whole cell patch-clamp study on the pacemaker potential in dopaminergic neurons of rat substantia nigra compacta

1993 • 124 citations

Synaptic innervation of midbrain dopaminergic neurons by glutamate-enriched terminals in the squirrel monkey

1996 • 123 citations

Burst firing of mesencephalic dopamine neurons is inhibited by somatodendritic application of kynurenate

1991 • 122 citations

Amphetamine selectively blocks inhibitory glutamate transmission in dopamine neurons

2001 • 122 citations

A10 somatodendritic dopamine autoreceptor sensitivity following withdrawal from repeated cocaine treatment

1990 • 122 citations

Evidence that systemically administered dopamine antagonists activate dopamine neuron firing primarily by blockade of somatodendritic autoreceptors.

1994 • 121 citations

Chapter 20 D1 and D2 dopamine receptor modulation of sodium and potassium currents in rat neostriatal neurons

1993 • 121 citations

Pedunculopontine-evoked excitation of substantia nigra neurons in the rat

1984 • 119 citations

Subthalamic Stimulation-Induced Synaptic Responses in Substantia Nigra Pars Compacta Dopaminergic Neurons In Vitro

1999 • 118 citations

Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors

1994 • 118 citations

Alpha₁‐adrenergic Effects on Dopamine Neurons Recorded Intracellularly in the Rat Midbrain Slice

1995 • 114 citations

Effects of chronic Δ9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment

2000 • 114 citations

Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitro

1988 • 113 citations

Different mechanisms for dopaminergic excitation induced by opiates and cannabinoids in the rat midbrain

2000 • 112 citations

Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurones

1982 • 111 citations

Functional Roles of Dopamine D₂and D₃Autoreceptors on Nigrostriatal Neurons Analyzed by Antisense KnockdownIn Vivo

1997 • 109 citations

Postsynaptic nicotinic receptors on dopaminergic neurons in the substantia nigra pars compacta of the rat

1998 • 107 citations

Visualization of rat brain receptors for the neuropeptide, substance P

1984 • 106 citations

Dopaminergic neurons in the rat ventral tegmental area. II. Evidence for autoregulation

1981 • 105 citations

Evidence for the presence of N-methyl-d-aspartate receptors in the ventral tegmental area of the rat: an electrophysiological in vitro study

1990 • 103 citations

Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra

1987 • 101 citations

Untitled

1998 • 101 citations

GABA_B‐Receptor activation alters the firing pattern of dopamine neurons in the rat substantia nigra

1993 • 100 citations

The D 3 dopamine receptor in cellular and organismal function

1998 • 98 citations

Ultrastructure and synaptic targets of the raphe-nigral projection in the rat

1993 • 97 citations

Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas

2000 • 97 citations

The cholinergic innervation of the rat substantia nigra: a light and electron microscopic immunohistochemical study

1988 • 97 citations

The role of GABA receptors in the control of nigrostriatal dopaminergic neurons: Dual-probe microdialysis study in awake rats

1992 • 96 citations

Are presynaptic dopamine autoreceptors and postsynaptic dopamine receptors in the rabbit caudate nucleus pharmacologically different?

1982 • 94 citations

Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats

2000 • 94 citations

Electrophysiological responses to dopamine of rat hypophysial cells in lactotroph‐enriched primary cultures.

1987 • 94 citations

Presynaptic GABA_B and adenosine A₁ receptors regulate synaptic transmission to rat substantia nigra reticulata neurones

1997 • 93 citations

Autoreceptor-mediated changes in dopaminergic terminal excitability: Effects of striatal drug infusions

1984 • 92 citations

Some Observations on Adrenergic Connections between Mesencephalon and Cerebral Hemispheres

1964 • 90 citations

Effects of a cannabinoid on spontaneous and evoked neuronal activity in the substantia nigra pars reticulata

1995 • 89 citations

Synaptic connections between pars compacta and pars reticulata neurones: electrophysiological evidence for functional modules within the substantia nigra

1994 • 87 citations

Cholecystokinin-like peptides potentiate apomorphine-induced inhibition of dopamine neurons

1983 • 86 citations

Drug Dependence as a Disorder of Neural Plasticity: Focus on Dopamine and Glutamate

2001 • 86 citations

Sub-populations of pars compacta neurons in the substantia nigra: The significance of qualitatively and quantitatively distinct conductances

1992 • 85 citations

Firing patterns of midbrain dopamine neurons: differences between A9 and A10 cells

1988 • 84 citations

Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra

1985 • 84 citations

A possible pacemaker mechanism in pars compacta neurons of the guinea-pig substantia nigra revealed by various ion channel blocking agents

1989 • 84 citations

Heterogeneity of neurons in the subnucleus interpolaris of the cat

1984 • 84 citations

Postnatal rat nigrostriatal dopaminergic neurons exhibit five types of potassium conductances

1990 • 82 citations

Evidence that non-NMDA receptors are involved in the excitatory pathway from the pedunculopontine region to nigrostriatal dopaminergic neurons

1992 • 81 citations

Inhibitory synaptic potentials in guinea‐pig substantia nigra dopamine neurones in vitro.

1994 • 80 citations

Anesthetic influences on the basal acticity and pharmacological responsiveness of nigrostriatal dopamine neurons

1990 • 80 citations

Immunocytochemical demonstration of GABAergic synaptic connections in rat substantia nigra after different lesions of the striatonigral projection

1988 • 78 citations

Pharmacological reduction of small conductance calcium-activated potassium current (SK) potentiates the excitatory effect of ethanol on ventral tegmental area dopamine neurons.

1999 • 77 citations

Electrophysiological and pharmacological characterization of identified nigrostriatal and mesoaccumbens dopamine neurons in the rat

1988 • 75 citations

Haloperidol given chronically decreases basal dopamine in the prefrontal cortex more than the striatum or nucleus accumbens as simultaneously measured by microdialysis

1989 • 74 citations

Sodium dynamics underlying burst firing and putative mechanisms for the regulation of the firing pattern in midbrain dopamine neurons: a computational approach.

1999 • 74 citations

Modulation of In Vivo Dopamine Release by D₂ but Not D₁ Receptor Agonists and Antagonists

1987 • 74 citations

Acute withdrawal after repeated ethanol treatment reduces the number of spontaneously active dopaminergic neurons in the ventral tegmental area

1993 • 73 citations

Amphetamine-induced release of dopamine from the substantia nigra

1976 • 73 citations

Demonstration of the existence of small local circuit neurons in the Golgi-stained primate substantia nigra

1979 • 71 citations

Group I Metabotropic Glutamate Receptors Mediate an Inward Current in Rat Substantia Nigra Dopamine Neurons That Is Independent From Calcium Mobilization

1999 • 70 citations

Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons

1993 • 69 citations

Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by γ-hydroxybutyric acid (GHBA) are specifically induced by activation of GABAB receptors

1998 • 67 citations

Low doses of γ-hydroxybutyric acid stimulate the firing rate of dopaminergic neurons in unanesthetized rats

1991 • 67 citations

GABAA receptor stimulation blocks NMDA-induced bursting of dopaminergic neurons in vitro by decreasing input resistance

1999 • 67 citations

Autoreceptor-mediated changes in dopaminergic terminal excitability: Effects of increases in impulse flow

1984 • 66 citations

Long-term amphetamine treatment attenuates or reverses the depression of neuronal activity produced by dopamine agonists in the ventral tegmental area

1984 • 66 citations

Light and electron microscopic immunohistochemical studies of serotonin nerve fibers in the substantia nigra of the rat, cat and monkey

1987 • 65 citations

5-Hydroxytryptamine and 5-hydroxytryptaminergic-dopaminergic interactions in the ventral tegmental area of rat brain

1982 • 65 citations

Dorsal raph� stimulation modifies striatal-evoked antidromic invasion of nigral dopaminergic neurons in vivo

1991 • 64 citations

Glutamate Metabotropic Receptor Agonists Depress Excitatory and Inhibitory Transmission on Rat Mesencephalic Principal Neurons

1997 • 62 citations

Decreased activity of rat A10 dopamine neurons following withdrawal from repeated cocaine

1992 • 61 citations

Clonidine regularizes substantia nigra dopamine cell firing

1988 • 60 citations

Electrophysiological effects of amphetamine on dopaminergic neurons

1973 • 60 citations

The selective NK₃ receptor agonist senktide excites a subpopulation of dopamine‐sensitive neurones in the rat substantia nigra pars compacta in vitro

1992 • 59 citations

Chapter 17 Neurotransmitter receptors and ionic conductances regulating the activity of neurones in substantia nigra pars compacta and ventral tegmental area

1993 • 59 citations

The ultrastructural morphology of the subthalamic-nigral axon terminals intracellularly labeled with horseradish peroxidase

1984 • 59 citations

Depolarization inactivation of dopamine neurons: Terminal release characteristics

1993 • 58 citations

Differential effects after repeated treatment with haloperidol, clozapine, thioridazine and tefludazine on SNC and VTA dopamine neurones in rats

1988 • 58 citations

Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra.

1994 • 58 citations

l-Glutamate excitation of A10 dopamine neurons is preferentially mediated by activation of NMDA receptors: extra- and intracellular electrophysiological studies in brain slices

1993 • 58 citations

Differential effects of repeated administration of novel antipsychotic drugs on the activity of midbrain dopamine neurons in the rat

1995 • 57 citations

Repeated haloperidol administration changes basal release of striatal dopamine and subsequent response to haloperidol challenge

1989 • 57 citations

Grafted septal neurons form cholinergic synaptic connections in the dentate gyrus of behaviorally impaired aged rats

1986 • 57 citations

Comparison between the pharmacology of dopamine receptors mediating the inhibition of cell firing in rat brain slices through the substantia nigra pars compacta and ventral tegmental area

1994 • 57 citations

Chronic ethanol administration alters activity in ventral tegmental area neurons after cessation of withdrawal hyperexcitability

1998 • 57 citations

Muscarinic receptors depress GABAergic synaptic transmission in rat midbrain dopamine neurons

2000 • 55 citations

LACK OF TOLERANCE TO ETHANOL-INDUCED STIMULATION OF MESOLIMBIC DOPAMINE SYSTEM

1992 • 54 citations

Electrophysiological analysis of dopamine cells from the substantia nigra pars compacta of circling rats

1989 • 54 citations

Electrophysiological, biochemical, and behavioral studies of acute haloperidol-induced depolarization block of nigral dopamine neurons

1992 • 54 citations

Gamma-hydroxybutyric acid as a signaling molecule in brain

2000 • 53 citations

Differential sensitivity of presumed dopaminergic and non-dopaminergic neurones in rat substantia nigra to electrophoretically applied substance P

1982 • 52 citations

Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic neuronal influences

1987 • 51 citations

D-2 dopamine-receptors regulate the release of [3H]dopamine in rat cortical regions showing dopamine immunoreactive fibers

1987 • 51 citations

Dopaminergic and neostriatal neurons: Dose-dependent changes in sensitivity to amphetamine following long-term treatment

1983 • 50 citations

Chemical neurotransmission : 75 years

1981 • 50 citations

The mechanism of amphetamine‐induced inhibition of rat substantia nigra compacta neurones investigated with intracellular recording in vitro

1989 • 49 citations

Stress, prolactin and hypothalamic dopaminergic neurons

1987 • 48 citations

Changes in dopaminergic terminal excitability induced by amphetamine and haloperidol

1981 • 47 citations

Effects of phencyclidine, MK-801 and 1,3-di(2-tolyl) guanidine on non-dopaminergic midbrain neurons

1993 • 47 citations

Nigral dopamine autoreceptors are exclusively of the D2 type: Quantitative autoradiography of [125I]iodosulpride and [125I]SCH 23982 in adjacent brain sections

1988 • 47 citations

Actions of substance P and opiates in the rat substantia nigra

1982 • 47 citations

A subpopulation of mesocortical dopamine neurons possesses autoreceptors

1984 • 47 citations

Local pressure application of cannabinoid agonists increases spontaneous activity of rat substantia nigra pars reticulata neurons without affecting response to iontophoretically-applied GABA

1996 • 47 citations

Diminished responses of nigral dopaminergic neurons to haloperidol and morphine following lesions in the striatum

1980 • 46 citations

Alterations in Baseline Activity and Quinpirole Sensitivity in Putative Dopamine Neurons in the Substantia Nigra and Ventral Tegmental Area after Withdrawal from Cocaine Pretreatment

1998 • 46 citations

Striatal Extracellular Dopamine Levels in Rats with Haloperidol-Induced Depolarization Block of Substantia Nigra Dopamine Neurons

1998 • 46 citations

GABA terminal autoreceptors in the pars compacta and in the pars reticulata of the rat substantia nigra are GABAB

1990 • 46 citations

Neurotensin attenuates the quinpirole-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area

1999 • 45 citations

Effect of catecholamines on the hyperpolarization‐activated cationic I_h and the inwardly rectifying potassium I_Kir currents in the rat substantia nigra pars compacta

1999 • 42 citations

Spontaneous bursting activity of dopaminergic neurons in midbrain slices from immature rats: role of N-methyl-d-aspartate receptors

1997 • 41 citations

Depolarization inactivation of dopamine neurons: an artifact?

1995 • 41 citations

Inhibition of nigral dopamine neurons by systemic and local apomorphine: Possible contribution of dendritic autoreceptors

1992 • 40 citations

Nigral dopaminergic neurons: differential sensitivity to apomorphine following long-term treatment with low and high doses of amphetamine

1984 • 39 citations

Do silent dopaminergic neurons exist in rat substantia nigra in vivo?

1998 • 39 citations

Stimulation of D-2 dopamine receptors in rat mesocortical areas inhibits the release of [3H]dopamine

1985 • 37 citations

Absence of synthesis-modulating nerve terminal autoreceptors on mesoamygdaloid and other mesolimbic dopamine neuronal populations

1987 • 37 citations

Mesocortical dopaminergic neurons. 1. Electrophysiological properties and evidence for soma-dendritic autoreceptors

1989 • 37 citations

Evidence for the functional compartmentalization of spike generating regions of rat mdbrain dopamine neurons recorded in vitro

1990 • 37 citations

Subsensitivity of catecholaminergic neurons to direct acting agonists after single or repeated electroconvulsive shock.

1982 • 35 citations

Presynaptic Receptors and the Question of Autoregulation of Neurotransmitter Release

1990 • 35 citations

Excitation of substantia nigra pars compacta neurones by 5-hydroxy-tryptamine in-vitro

1991 • 35 citations

Effects of haloperidol on the activity and membrane physiology of substantia nigra dopamine neurons recorded in vitro

1996 • 35 citations

Neurotensin and dopamine D2 activation oppositely regulate the same K+ conductance in rat midbrain dopaminergic neurons

1997 • 34 citations

Metabotropic glutamate receptor-mediated inhibition and excitation of substantia nigra dopamine neurons

1997 • 34 citations

PRESYNAPTIC RECEPTORS AND THE QUESTION OF AUTOREGULATION OF NEUROTRANSMITTER RELEASE

1990 • 33 citations

Neuronal responses to iontophoretically applied dopamine, glutamate, and GABA of identified dopaminergic cells in the rat substantia nigra after kainic acid-induced destruction of the striatum

1982 • 32 citations

Activation of nigral dopamine neurons by the selective GABA B -receptor antagonist SCH 50911

1999 • 31 citations

Olanzapine, a novel atypical antipsychotic, reversesd-amphetamine-induced inhibition of midbrain dopamine cells

1996 • 31 citations

ELECTROPHYSIOLOGICAL EFFECTS OF AMPHETAMINE ON DOPAMINERGIC NEURONS

1973 • 30 citations

The neuropharmacology of the autoinhibition of monoamine release

1985 • 30 citations

D2S, D2L, D3, and D4 dopamine receptors couple to a voltage-dependent potassium current in N18TG2 � mesencephalon hybrid cell (MES-23.5) via distinct G proteins

1999 • 30 citations

Direct demonstration of interactions between substance P immunoreactive terminals and tyrosine hydroxylase immunoreactive neurons in the substantia nigra of the rat: An ultrastructural study

1988 • 29 citations

The Basal Ganglia VI

2003 • 29 citations

Nicotine withdrawal leads to increased firing rates of midbrain dopamine neurons.

1995 • 29 citations

Biochemical and electrophysiological effects of 7‐OH‐DPAT on the mesolimbic dopaminergic system

1995 • 28 citations

Effects of Chronic Haloperidol on Stress- and Stimulation-Induced Increases in Dopamine Release: Tests of the Depolarization Block Hypothesis

1996 • 27 citations

Peripheral and striatal influences on nigral dopamine cells: Mediation by reticulata neurons

1980 • 27 citations

Release of endogenous dopamine from corpus striatum

1978 • 27 citations

Ethanol withdrawal does not induce a reduction in the number of spontaneously active dopaminergic neurons in the mesolimbic system

1995 • 26 citations

The Effect of Intravenous Administration of Delta-9-Tetrahydrocannabinol on the Activity of A10 Dopamine Neurons Recorded in vivo in Anesthetized Rats

1997 • 26 citations

Antidromic latency variations of nigral compacta neurones

1980 • 25 citations

Release of cholecystokinin from rat midbrain slices and modulatory effect of D2 DA receptor stimulation

1991 • 25 citations

Is the Release of Dopamine from Medial Prefrontal Cortex Modulated by Presynaptic Receptors? Comparison with Nigrostriatal and Mesolimbic Terminals

1990 • 24 citations

Effects of Lesions in the Medial Prefrontal Cortex on the Activity of Midbrain Dopamine Neurons

1996 • 23 citations

Failure of chronic haloperidol to induce depolarization inactivation of dopamine neurons in unanesthetized rats

1994 • 23 citations

Modulation of terminal excitability of mesolimbic dopaminergic neurons by d-amphetamine and haloperidol

1985 • 23 citations

Haloperidol does not produce dopamine cell depolarization-block in paralyzed, unanesthetized rats

1998 • 22 citations

Electron microscopic evidence for the existence of a corticonigral tract in the cat.

1982 • 22 citations

Nicotine withdrawal leads to increased firing rates of midbrain dopamine neurons

1995 • 22 citations

The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum.

1988 • 22 citations

Electrophysiological evidence for the presence of ionotropic and metabotropic excitatory amino acid receptors on dopaminergic neurons of the rat mesencephalon: an in vitro study.

1992 • 21 citations

The progressive changes of neuronal activities of the nigral dopaminergic neurons upon withdrawal from continuous infusion of cocaine

1992 • 21 citations

Cortically Induced Inhibition of Neurons of Rat Substantia Nigra (Pars Compacta)

1979 • 21 citations

N-Methyl-d-aspartate receptors mediate a slow excitatory postsynaptic potential in the rat midbrain dopaminergic neurons

1996 • 20 citations

CCK-8 excites substantia nigra dopaminergic neurons by increasing a cationic conductance

1994 • 20 citations

Drug Addiction and Related Clinical Problems

1995 • 20 citations

Characterization of a tropane radioligand, [(3)H]2beta-propanoyl-3beta-(4-tolyl) tropane ([(3)H]PTT), for dopamine transport sites in rat brain.

2000 • 20 citations

Single-channel properties of the nonselective cation conductance induced by neurotensin in dopaminergic neurons

1996 • 19 citations

Effects of glycine on neurons in the rat substantia nigra zona compacta: In vitro electrophysiological study

1990 • 19 citations

Mesocortical dopaminergic neurons. 2. Electrophysiological consequences of terminal autoreceptor activation

1989 • 19 citations

Competitive NMDA receptor antagonists differentially affect dopamine cell firing pattern

1997 • 15 citations

Sensitivity of neuronal dopamine response in the substantia nigra and ventral tegmentum to clozapine, metoclopramide and SCH 23390

1987 • 15 citations

Depletion in substance P- and neurokinin A-like immunoreactivity in substantia nigra after ibotenate-induced lesions of striatum

1987 • 14 citations

Drugs of Abuse and Dopamine Cell Activity

1997 • 14 citations

Modulation of dopaminergic terminal excitability by D1 selective agents

1989 • 14 citations

Tegmentonigral projection in the cat: electron microscopic observations.

1984 • 12 citations

Haloperidol-induced alteration of post-firing inhibition in dopaminergic neurons of rat substantia nigra

1979 • 11 citations

Heterogeneous responses of substantia nigra pars reticulata neurons to γ-hydroxybutyric acid administration

1993 • 11 citations

Firing patterns in substantia nigra compacta identified neurons in vitro.

1995 • 10 citations

Modulation of dopaminergic terminal excitability by D1 selective agents: Further characterization

1991 • 10 citations

In Vivo Electrophysiology of Central Nervous System Terminal Autoreceptors

1990 • 8 citations

AFFERENT CONTROL OF NIGRAL DOPAMINERGIC NEURONS The role of GABAergic inputs

2002 • 8 citations

Central Dopaminergic Mechanisms of Alcohol and Opiate Withdrawal Syndromes

1995 • 8 citations

Effects of long-term administration of haloperidol on electrophysiologic properties of rat mesencephalic neurons.

1990 • 7 citations

Pertussis Toxin Lesions of the Rat Substantia Nigra Block the Inhibitory Effects of the γ-Hydroxybutyrate Agent, S(-)HA-966 without Affecting the Basal Firing Properties of Dopamine Neurons

1999 • 6 citations

DOPAMINERGIC NEUROTRANSMISSION AND DRUG WITHDRAWAL Relevance to Drug Craving

1996 • 6 citations

Amphetamine-induced changes in nigrostriatal terminal excitability are modified following repeated amphetamine pretreatment

1996 • 5 citations

Subcortical excitatory inputs to nigral dopaminergic and non-dopaminergic neurons: A light and Electron Microscopic study

1993 • 3 citations