Drug Dependence as a Disorder of Neural Plasticity: Focus on Dopamine and Glutamate

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

1988 • 4,617 citations

Stereotaxic Mapping of the Monoamine Pathways in the Rat Brain*

1971 • 3,816 citations

FLUORESCENCE OF CATECHOL AMINES AND RELATED COMPOUNDS CONDENSED WITH FORMALDEHYDE

1962 • 2,684 citations

Drug Abuse: Hedonic Homeostatic Dysregulation

1997 • 2,472 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

From motivation to action: Functional interface between the limbic system and the motor system

1980 • 2,292 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 2,110 citations

Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity

1991 • 2,025 citations

Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

1986 • 1,751 citations

Opioids excite dopamine neurons by hyperpolarization of local interneurons

1992 • 1,585 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Inhibition of Morphine Tolerance and Dependence by the NMDA Receptor Antagonist MK-801

1991 • 1,212 citations

Transition from Moderate to Excessive Drug Intake: Change in Hedonic Set Point

1998 • 1,127 citations

Neuroscience of Addiction

1998 • 1,030 citations

Reinstatement of cocaine-reinforced responding in the rat

1981 • 936 citations

Projections from the Rat Prefrontal Cortex to the Ventral Tegmental Area: Target Specificity in the Synaptic Associations with Mesoaccumbens and Mesocortical Neurons

2000 • 872 citations

Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area

1992 • 832 citations

Demonstration and mapping out of nigro-neostriatal dopamine neurons

1964 • 796 citations

Low doses of ethanol activate dopaminergic neurons in the ventral tegmental area

1985 • 788 citations

The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems

1987 • 788 citations

Nicotine activates and desensitizes midbrain dopamine neurons

1997 • 762 citations

Involvement of the amygdala in stimulus-reward associations: Interaction with the ventral striatum

1989 • 662 citations

Self-inhibition by Dopaminergic Neurons

1975 • 645 citations

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

1984 • 644 citations

Localization of monoamines in the lower brain stem

1964 • 628 citations

Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist

1999 • 565 citations

Drug addiction: A model for the molecular basis of neural plasticity

1993 • 548 citations

Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction

2000 • 545 citations

Neuronal localization of cannabinoid receptors in the basal ganglia of the rat

1991 • 515 citations

Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra

1978 • 498 citations

Morphine-induced activation of A10 dopamine neurons in the rat

1983 • 485 citations

Conditioned responses to cocaine-related stimuli in cocaine abuse patients

1992 • 457 citations

Interactions between the amygdala and ventral striatum in stimulus-reward associations: Studies using a second-order schedule of sexual reinforcement

1989 • 455 citations

Ethanol Self-Administration Restores Withdrawal-Associated Deficiencies in Accumbal Dopamine and 5-Hydroxytryptamine Release in Dependent Rats

1996 • 455 citations

In the rat medial nucleus accumbens, hippocampal and catecholaminergic terminals converge on spiny neurons and are in apposition to each other

1990 • 443 citations

Enhanced behavioural control by conditioned reinforcers following microinjections of d-amphetamine into the nucleus accumbens

1984 • 440 citations

Electrophysiological evidence for excitation of rat ventral tegmental area dopamine neurons by morphine

1984 • 424 citations

Preclinical Evaluation of Pharmacotherapies for Treatment of Cocaine and Opioid Abuse Using Drug Self-Administration Procedures

1996 • 385 citations

Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra

1997 • 366 citations

Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors

1998 • 363 citations

Chemical Stimulation of Synaptosomes Modulates α-Ca²⁺/Calmodulin-Dependent Protein Kinase II mRNA Association to Polysomes

2000 • 359 citations

Repeated cocaine administration causes persistent enhancement of D1 dopamine receptor sensitivity within the rat nucleus accumbens.

1991 • 359 citations

GABAA receptor-mediated inhibition of rat substantia nigra dopaminergic neurons by pars reticulata projection neurons

1995 • 356 citations

Functions of dopamine in the dorsal and ventral striatum

1992 • 340 citations

Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex

1996 • 331 citations

Properties and Plasticity of Excitatory Synapses on Dopaminergic and GABAergic Cells in the Ventral Tegmental Area

1999 • 317 citations

Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: studies in the ventral tegmental area

1988 • 313 citations

Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: electrophysiological and biochemical evidence.

1993 • 308 citations

The localization of monoaminergic blood-brain barrier mechanisms.

1966 • 299 citations

Synaptic Regulation of Mesocorticolimbic Dopamine Neurons

1996 • 289 citations

Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor.

1993 • 282 citations

Increased Probability of GABA Release during Withdrawal from Morphine

1997 • 279 citations

Chronic morphine induces visible changes in the morphology of mesolimbic dopamine neurons.

1996 • 276 citations

Preferential stimulation of ventral tegmental area dopaminergic neurons by nicotine

1987 • 275 citations

Opponent process theory of motivation: Neurobiological evidence from studies of opiate dependence

1989 • 264 citations

Dopamine release in the nucleus caudatus and in the nucleus accumbens is under glutamatergic control through non-NMDA receptors: a study in freely-moving rats

1990 • 260 citations

Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens

1992 • 257 citations

Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum

1995 • 243 citations

Partial agonists, full agonists, antagonists: dilemmas of definition

1993 • 234 citations

Δ9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors

1997 • 227 citations

Involvement of D2 dopamine receptors in the nucleus accumbens in the opiate withdrawal syndrome

1994 • 214 citations

Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects.

2000 • 213 citations

Modulation of Long-Term Depression by Dopamine in the Mesolimbic System

2000 • 211 citations

Response of nucleus accumbens neurons to amygdala stimulation and its modification by dopamine

1982 • 211 citations

Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats

1984 • 208 citations

Simultaneous LTP of non-NMDA- and LTD of NMDA-receptor-mediated responses in the nucleus accumbens

1994 • 205 citations

MK-801 prevents alterations in the mesoaccumbens dopamine system associated with behavioral sensitization to amphetamine

1994 • 203 citations

Marijuana's interaction with brain reward systems: Update 1991

1991 • 199 citations

The Effects of NMDA Receptor Antagonists and Nitric Oxide Synthase Inhibitors on Opioid Tolerance and Withdrawal Medication Development Issues for Opiate Addiction

1995 • 197 citations

Inhibition of opiate tolerance by non-competitive N-d-aspartate receptor antagonists

1994 • 191 citations

Mesolimbic dopaminergic decline after cannabinoid withdrawal

1998 • 189 citations

Increased Glutamatergic Neurotransmission and Oxidative Stress After Alcohol Withdrawal

1998 • 189 citations

The Neuronal Nitric Oxide Synthase Inhibitor, 7‐Nitroindazole, Protects Against Methamphetamine‐Induced Neurotoxicity In Vivo

1996 • 185 citations

Alcohol Self‐Administration: Further Examination of the Role of Dopamine Receptors in the Nucleus Accumbens

1997 • 185 citations

Chronic Alterations in Dopaminergic Neurotransmission Produce a Persistent Elevation of ΔFosB‐like Protein(s) in both the Rodent and Primate Striatum

1996 • 180 citations

Drug-induced reinstatement of extinguished self-administration behavior in monkeys

1975 • 180 citations

Drugs of abuse: behavioural principles, methods and terms

1992 • 177 citations

Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat

1985 • 175 citations

Synaptic Plasticity in an In Vitro Slice Preparation of the Rat Nucleus Accumbens

1993 • 174 citations

Behavioral effects of selective dopaminergic compounds in rats discriminating cocaine injections.

1991 • 173 citations

Mapping out of catecholamine and 5-hydroxytryptamine neurons innervating the telencephalon and diencephalon

1965 • 173 citations

Physical withdrawal in rats tolerant to Δ9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist

1995 • 170 citations

Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats.

1995 • 167 citations

Mechanism of Action of Acamprosate. Part I. Characterization of Spermidine‐Sensitive Acamprosate Binding Site in Rat Brain

1998 • 165 citations

DNQX blockade of amphetamine behavioral sensitization

1991 • 163 citations

Central effects of acamprosate: Part 1. Acamprosate blocks the glutamate increase in the nucleus accumbens microdialysate in ethanol withdrawn rats

1998 • 163 citations

Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal.

1996 • 158 citations

D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat

1993 • 157 citations

Low doses of ethanol inhibit the firing of neurons in the substantia nigra, pars reticulata: a GABAergic effect?

1985 • 155 citations

Presynaptic Regulation of Glutamate Release in the Ventral Tegmental Area During Morphine Withdrawal

1999 • 152 citations

Amphetamine Blocks Long-Term Synaptic Depression in the Ventral Tegmental Area

2000 • 151 citations

Effects of morphine and haloperidol on the electrical activity of rat nigrostriatal neurons.

1977 • 149 citations

Ethanol inhibits glutamatergic neurotransmission in nucleus accumbens neurons by multiple mechanisms.

1994 • 147 citations

Δ9-Tetrahydroeannabinol enhances presynaptic dopamine efflux In medial prefrontal cortex

1990 • 142 citations

Alcohol Craving; Subjective and Situational Aspects

1974 • 136 citations

Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine

1991 • 131 citations

Dopamine receptor agonists: Mechanisms underlying autoreceptor selectivity II. Theoretical considerations

1985 • 131 citations

Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids

1998 • 130 citations

Cocaine Abuse and Dependence

1995 • 128 citations

Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal

1999 • 126 citations

Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A

1995 • 126 citations

Sensitization and Tolerance in Psychostimulant Self-Administration

1997 • 125 citations

NMDA receptors in the nucleus accumbens modulate intravenous cocaine but not heroin self-administration in the rat

1992 • 124 citations

Topographic organization of collateral projections from the basolateral amygdaloid nucleus to both the prefrontal cortex and nucleus accumbens in the rat

1994 • 123 citations

A10 somatodendritic dopamine autoreceptor sensitivity following withdrawal from repeated cocaine treatment

1990 • 122 citations

Glutamate antagonists prevent morphine withdrawal in mice and guinea pigs

1991 • 116 citations

Effects of the AMPA receptor antagonist NBQX on the development and expression of behavioral sensitization to cocaine and amphetamine

1997 • 115 citations

NMDA receptors mediate the behavioral effects of amphetamine infused into the nucleus accumbens

1992 • 114 citations

The reinforcing effects of dopamine D1 receptor agonists in rhesus monkeys.

1995 • 111 citations

Distinct actions of endogenous excitatory amino acids on the outflow of dopamine in the nucleus accumbens.

1993 • 110 citations

Dopamine receptor agonists, partial agonists and psychostimulant addiction

1994 • 110 citations

Modulation of locomotor activity by NMDA receptors in the nucleus accumbens core and shell regions of the rat

1994 • 109 citations

Endogenous nitric oxide facilitates striatal dopamine and glutamate efflux in vivo: Role of ionotropic glutamate receptor-dependent mechanisms

1997 • 107 citations

Contribution of NMDA receptors to postsynaptic potentials and paired-pulse facilitation in identified neurons of the rat nucleus accumbens in vitro

1991 • 99 citations

Effects of a cannabinoid on spontaneous and evoked neuronal activity in the substantia nigra pars reticulata

1995 • 89 citations

Reinstatement of extinguished cocaine-taking behavior by cocaine and caffeine

1994 • 87 citations

Influence of Dopamine on Limbic Inputs to the Nucleus Accumbens

1988 • 87 citations

Pharmacological reduction of small conductance calcium-activated potassium current (SK) potentiates the excitatory effect of ethanol on ventral tegmental area dopamine neurons.

1999 • 77 citations

Acute withdrawal after repeated ethanol treatment reduces the number of spontaneously active dopaminergic neurons in the ventral tegmental area

1993 • 73 citations

The NMDA antagonist, dizocilpine, enhances cocaine reinforcement without influencing mesoaccumbens dopamine transmission

1997 • 70 citations

Glutamate-induced increase of extracellular glutamate through N-methyl-d-aspartate receptors in ethanol withdrawal

1999 • 68 citations

Systemic pretreatment with MK-801 (dizocilpine) increases breaking points for self-administration of cocaine on a progressive-ratio schedule in rats

1996 • 68 citations

Nitric oxide regulation of methamphetamine-induced dopamine release in caudate/putamen

1995 • 67 citations

Nitric oxide mediation of cocaine-induced dopaminergic behaviors: ambulation-accelerating activity, reverse tolerance and conditioned place preference in mice.

1995 • 66 citations

Ethanol Inhibition of Neuronal Giutamate Receptor Function

1990 • 65 citations

Pharmacological characterization of the discriminative-stimulus effects of GBR 12909.

1991 • 64 citations

Glutamate receptor regulation of rat nucleus accumbens neurons in vivo

1996 • 63 citations

Decreased activity of rat A10 dopamine neurons following withdrawal from repeated cocaine

1992 • 61 citations

Persistent increase in dopamine release following activation of metabotropic glutamate receptors in the rat nucleus accumbens

1995 • 61 citations

Chronic ethanol administration alters activity in ventral tegmental area neurons after cessation of withdrawal hyperexcitability

1998 • 57 citations

1-aminocyclopropane carboxylic acid (ACPC) prevents mu and delta opioid tolerance

1994 • 54 citations

LACK OF TOLERANCE TO ETHANOL-INDUCED STIMULATION OF MESOLIMBIC DOPAMINE SYSTEM

1992 • 54 citations

Selectivec-fos induction and decreased dopamine release in the central nucleus of amygdala in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome

2000 • 52 citations

MK-801 reinstates drug-seeking behaviour in cocaine-trained rats

1998 • 48 citations

Inhibition of nitric oxide formation reduces voluntary ethanol consumption in the rat

1996 • 43 citations

Discriminative stimulus properties of cocaine in relation to dopamine D2 receptor function in rats.

1993 • 42 citations

Effects of nitric oxide synthase inhibitors on cocaine sensitization

1997 • 39 citations

Seeing a Mountain in a Grain of Garnet

1997 • 37 citations

Inhibition of Nitric Oxide Synthesis Reduces Intravenous Cocaine Self-administration in the Rat

1996 • 37 citations

Inhibition of glutamate reuptake potentiates endogenous nitric oxide-facilitated dopamine efflux in the rat striatum: an in vivo microdialysis study

1997 • 36 citations

Craving and drug reward: a comparison of methadone and clonidine in detoxifying opiate addicts

1995 • 36 citations

Effects of nicotine on dopaminergic nigrostriatal axons requires stimulation of presynaptic glutamatergic receptors.

1996 • 30 citations

Nitric oxide facilitates N-methyl-d-aspartate-induced burst firing in dopamine neurons from rat midbrain slices

1998 • 27 citations

Ethanol withdrawal does not induce a reduction in the number of spontaneously active dopaminergic neurons in the mesolimbic system

1995 • 26 citations

Discriminative stimulus effects of cocaine in squirrel monkeys: Lack of antagonism by the dopamine D2 partial agonists terguride, SDZ 208-911, and SDZ 208-912

1995 • 16 citations

Drugs of Abuse and Dopamine Cell Activity

1997 • 14 citations