Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB ₁ Receptor Knockout Mice

1999 • 3,597 citations

Reversal of Experimental Parkinsonism by Lesions of the Subthalamic Nucleus

1990 • 1,875 citations

Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: An anterograde tract‐tracing study with Phaseolus vulgaris leucoagglutinin

1989 • 1,570 citations

The control of firing pattern in nigral dopamine neurons: burst firing

1984 • 1,326 citations

Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity.

1973 • 1,272 citations

Intracellular and extracellular electrophysiology of nigral dopaminergic neurons—1. Identification and characterization

1983 • 925 citations

The control of firing pattern in nigral dopamine neurons: single spike firing

1984 • 856 citations

The role of divalent cations in the N‐methyl‐D‐aspartate responses of mouse central neurones in culture.

1988 • 810 citations

Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro

1989 • 734 citations

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

1988 • 663 citations

Efferent projections of the subthalamic nucleus in the rat: Light and electron microscopic analysis with the PHA‐L method

1987 • 580 citations

Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity

1978 • 550 citations

Lesion of the subthalamic nucleus for the alleviation of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced parkinsonism in the primate

1991 • 526 citations

Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra

1978 • 498 citations

Precise Localization of Renshaw Cells with a New Marking Technique

1965 • 471 citations

Ibotenic acid-induced neuronal degeneration: A morphological and neurochemical study

1979 • 467 citations

Neural mechanisms underlying parkinsonian symptoms based upon regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1989 • 455 citations

Occurrence of neurotensinlike immunoreactivity in subpopulations of hypothalamic, mesencephalic, and medullary catecholamine neurons

1984 • 439 citations

Altered Tonic Activity of Neurons in the Globus Pallidus and Subthalamic Nucleus in the Primate MPTP Model of Parkinsonism

1987 • 420 citations

Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons

1979 • 393 citations

The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique

1976 • 374 citations

Dopamine neurons of the monkey midbrain: contingencies of responses to active touch during self-initiated arm movements

1990 • 350 citations

Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data

1990 • 343 citations

Dopamine neurons of the monkey midbrain: contingencies of responses to stimuli eliciting immediate behavioral reactions

1990 • 326 citations

Afferent connections of the subthalamic nucleus: a combined retrograde and anterograde horseradish peroxidase study in the rat

1990 • 294 citations

Burst firing induced in midbrain dopamine neurons by stimulation of the medial prefrontal and anterior cingulate cortices

1988 • 281 citations

Opposing effects of striatonigral feedback pathways on midbrain dopamine cell activity

1985 • 279 citations

Connections of the subthalamic nucleus with ventral striatopallidal parts of the basal ganglia in the rat

1990 • 277 citations

Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition

1989 • 266 citations

Intracellular study of rat substantia nigra pars reticulata neurons in an in vitro slice preparation: electrical membrane properties and response characteristics to subthalamic stimulation

1987 • 243 citations

Nigral Dopamine Neurons: Intracellular Recording and Identification with L-Dopa Injection and Histofluorescence

1980 • 239 citations

Firing properties of substantia nigra dopaminergic neurons in freely moving rats

1985 • 235 citations

CENTRAL DOPAMINERGIC NEURONS: NEUROPHYSIOLOGICAL IDENTIFICATION AND RESPONSES TO DRUGS**This research was supported by NIMH Grant MH-17871, USPHS Research Scientist Development Award MH-14459 (to G. K. A.), and the State of Connecticut.

1973 • 230 citations

Anatomy and Physiology of the Subthalamic Nucleus: A Driving Force of the Basal Ganglia

1987 • 206 citations

Studies on the subthalamus of the rhesus monkey. II. Hyperkinesia and other physiologic effects of subthalamic lesions, with special reference to the subthalamic nucleus of Luys

1949 • 203 citations

Electrical membrane properties of rat substantia nigra compacta neurons in an in vitro slice preparation

1986 • 187 citations

Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: Importance of subcellular storage, nerve impulse frequency and pattern, feedback regulation and resupply by axonal transport

1989 • 184 citations

Pallidal inputs to subthalamus: Intracellular analysis

1983 • 183 citations

Unilateral lesion of the nigrostriatal pathway decreases the firing rate and alters the firing pattern of globus pallidus neurons in the rat

1988 • 183 citations

Single subthalamic nucleus neurons project to both the globus pallidus and substantia nigra in rat

1980 • 182 citations

Electrophysiological demonstration of an excitatory subthalamonigral pathway in the rat

1978 • 181 citations

Activity of A9 and A10 dopaminergic neurons in unrestrained rats: further characterization and effects of apomorphine and cholecystokinin

1987 • 164 citations

Subthalamic nucleus cell firing in the 6-OHDA-treated rat: basal activity and response to haloperidol

1992 • 163 citations

Topographical and Synaptic Organization of the GABA‐Containing Pallidosubthalamic Projection in the Rat

1990 • 163 citations

Ventral mesencephalic neurons containing both cholecystokinin‐ and tyrosine hydroxylase‐like immunoreactivities project to forebrain regions

1989 • 139 citations

Topographic Organization of Ascending Dopaminergic Projectionsa

1988 • 134 citations

The cortico-nigral projection: reduced glutamate content in the substantia nigra following frontal cortex ablation in the rat

1984 • 133 citations

Afferents to the rat substantia nigra studied with horseradish peroxidase, with special reference to fibres from the subthalamic nucleus

1976 • 132 citations

In vivo release of acetylcholinesterase in cat substantia nigra and caudate nucleus

1980 • 127 citations

Burst firing of mesencephalic dopamine neurons is inhibited by somatodendritic application of kynurenate

1991 • 122 citations

Experimental hemiballism in the monkey produced by unilateral kainic acid lesion in corpus Luysii

1979 • 121 citations

Local cerebral glucose utilization in monkeys with hemiparkinsonism induced by intracarotid infusion of the neurotoxin MPTP

1990 • 121 citations

Efferent connections of the subthalamic region in the rat. I. The subthalamic nucleus of luys

1980 • 120 citations

The acetylcholine-dopamine balance in the basal ganglia of rhesus monkeys and its role in dynamic, dystonic, dyskinetic, and epileptoid motor activities

1975 • 113 citations

Feline subthalamic nucleus neurons contain glutamate-like but not GABA-like or glycine-like immunoreactivity

1989 • 109 citations

The effects of dopamine-depleting brain lesions on the electrophysiological activity of rat substantia nigra dopamine neurons

1990 • 109 citations

Evidence for the presence of N-methyl-d-aspartate receptors in the ventral tegmental area of the rat: an electrophysiological in vitro study

1990 • 103 citations

The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia

1992 • 102 citations

Pharmacological blockade of the globus pallidus-induced inhibitory response of subthalamic cells in the rat

1980 • 98 citations

The excitatory amino acid antagonist kynurenate induces pacemaker‐like firing of dopamine neurons in rat ventral tegmental area in vivo

1998 • 78 citations

The Effects of Activation or Inhibition of the Subthalamic Nucleus on the Metabolic and Electrophysiological Activities Within the Pallidal Complex and Substantia Nigra in the Rat

1991 • 69 citations

Intracellular studies of dopamine neurons in vitro: pacemakers modulated by dopamine

1988 • 66 citations

Analysis of somatotopic relations of the corpus Luysi in man and monkey. Relation between the site of dyskinesia and distribution of lesions within the subthalamic nucleus

1951 • 62 citations

Hyperpolarizing action of baclofen on neurons in the rat substantia nigra slice

1984 • 54 citations

Electrophysiological analysis of dopamine cells from the substantia nigra pars compacta of circling rats

1989 • 54 citations

Action of systemic apomorphine on dopamine cell firing after neostriatal kainic acid lesion

1980 • 47 citations

Effects of dopamine autoreceptor stimulation on the release of colocalized transmitters: In vivo release of dopamine and neurotensin from rat prefrontal cortex

1990 • 40 citations

TRH: Historical Aspects

1989 • 39 citations

Two separate neuronal populations of the rat subthalamic nucleus project to the basal ganglia and pedunculopontine tegmental region

1988 • 34 citations

Effect of ethanol on subthreshold currents of Aplysia pacemaker neurons

1985 • 28 citations

Partial dopamine depletions result in an enhanced sensitivity of residual dopamine neurons to apomorphine

1991 • 25 citations

Recent advances in the use of selective neuron-destroying agents for neurobiological research

1984 • 22 citations

Spontaneous activity of Type II but not Type I striatal neurons is correlated with recovery of behavioral function after dopamine-depleting brain lesions

1988 • 20 citations

Separation of visual functions within the corpus callosum of monkeys

1973 • 15 citations