Mutations in the cytoplasmic domain of EGF receptor affect EGF binding and receptor internalization.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 • 4,786 citations

Epidermal Growth Factor

1979 • 2,964 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

CELLULAR ONCOGENES AND RETROVIRUSES

1983 • 1,671 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

An enzymic method for the trace iodination of immunoglobulins and other proteins

1969 • 1,414 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes.

1980 • 1,184 citations

Construction and applications of a highly transmissible murine retrovirus shuttle vector

1984 • 1,020 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

Recycling receptors: The round-trip itinerary of migrant membrane proteins

1983 • 780 citations

Epidermal growth factor induces rapid tyrosine phosphorylation of proteins in A431 human tumor cells

1981 • 669 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine

1980 • 539 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Journey to the Center of the Cell: Role of the Receptosome

1981 • 500 citations

A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.

1984 • 447 citations

Expression Cloning of Human EGF Receptor Complementary DNA: Gene Amplification and Three Related Messenger RNA Products in A431 Cells

1984 • 406 citations

Human epidermal growth factor and the proliferation of human fibroblasts

1976 • 403 citations

Amplification and Enhanced Expression of the Epidermal Growth Factor Receptor Gene in A431 Human Carcinoma Cells

1984 • 400 citations

Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts.

1984 • 357 citations

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

1985 • 310 citations

Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain

1985 • 301 citations

Resolution of high and low affinity epidermal growth factor receptors. Inhibition of high affinity component by low temperature, cycloheximide, and phorbol esters.

1982 • 271 citations

Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654.

1985 • 244 citations

Regulation of Cell Proliferation by Epidermal Growth Factor

1983 • 235 citations

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

1985 • 223 citations

Inhibition of epidermal growth factor binding to surface receptors by tumor promotors

1979 • 206 citations

Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation

1983 • 165 citations

Epidermal growth factor: Biological activity requires persistent occupation of high-affinity cell surface receptors

1978 • 162 citations

Epidermal growth factor. Ability of tumor promoter to alter its degradation, receptor affinity and receptor number.

1980 • 150 citations

A Short Sequence in the p60^src N Terminus Is Required for p60^src Myristylation and Membrane Association and for Cell Transformation

1984 • 149 citations

Fine structural mapping of a critical NH2-terminal region of p60src.

1985 • 129 citations

Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis

1984 • 113 citations

Purification of an active EGF receptor kinase with monoclonal antireceptor antibodies.

1985 • 98 citations

High affinity epidermal growth factor receptors on the surface of A431 cells have restricted lateral diffusion.

1984 • 97 citations

Lateral diffusion of epidermal growth factor complexed to its surface receptors does not account for the thermal sensitivity of patch formation and endocytosis

1982 • 93 citations

Epidermal growth factor: Is the precursor a receptor?

1985 • 81 citations

Transfection of Fibroblasts by Cloned Abelson Murine Leukemia Virus DNA and Recovery of Transmissible Virus by Recombination with Helper Virus

1982 • 78 citations

Cancer cells 2: Oncogenes and viral genes

1985 • 76 citations

The minimum transforming region of v-abl is the segment encoding protein-tyrosine kinase

1985 • 70 citations

Analysis of morphology and receptor metabolism in clonal variant A431 cells with differing growth responses to epidermal growth factor

1983 • 44 citations