Cytokines and transcription factors

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β

1988 • 620 citations

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-κB-like factor

1988 • 607 citations

α-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences

1985 • 498 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

Heat shock factor is regulated differently in yeast and HeLa cells

1987 • 489 citations

HTLV-I Tax Induces Cellular Proteins that Activate the κB Element in the IL-2 Receptor α Gene

1988 • 480 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Induction of protooncogene c-jun by serum growth factors.

1988 • 438 citations

The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV

1988 • 427 citations

Regulation of the human interleukin-2 receptor α chain promoter: Activation of a nonfunctional promoter by the transactivator gene of HTLV-I

1987 • 423 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product

1988 • 327 citations

Double-stranded RNA activates binding of NF-kappa B to an inducible element in the human beta-interferon promoter.

1989 • 317 citations

Interferon response element of the human gene 6-16.

1988 • 292 citations

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

1989 • 271 citations

A single DNA response element can confer inducibility by both alpha- and gamma-interferons.

1989 • 262 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

Regulation of Cytokine Gene Expression

1988 • 234 citations

Interferon-β gene regulation: Tandemly repeated sequences of a synthetic 6 bp oligomer function as a virus-inducible enhancer

1987 • 233 citations

Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes.

1989 • 230 citations

Two interferon-induced nuclear factors bind a single promoter element in interferon-stimulated genes.

1988 • 228 citations

Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells.

1989 • 218 citations

AP1/ jun Function Is Differentially Induced in Promotion-Sensitive and Resistant JB6 Cells

1989 • 210 citations

Functionally Distinct NF-κB Binding Sites in the Immunoglobulin κ and IL-2 Receptor α Chain Genes

1989 • 194 citations

Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer.

1988 • 180 citations

Interleukin 1 and cyclic AMP induce kappa immunoglobulin light-chain expression via activation of an NF-kappa B-like DNA-binding protein.

1989 • 176 citations

Interferon-induced transcription of a major histocompatibility class I gene accompanies binding of inducible nuclear factors to the interferon consensus sequence.

1988 • 170 citations

Two different virus-inducible elements are required for human beta-interferon gene regulation.

1989 • 168 citations

Regulation of a transfected human class II major histocompatibility complex gene in human fibroblasts.

1986 • 159 citations

B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.

1988 • 118 citations

A gamma-interferon-induced factor that binds the interferon response sequence of the MHC class I gene, H-2Kb.

1989 • 113 citations

Detailed delineation of an interferon-gamma-responsive element important in human HLA-DRA gene expression in a glioblastoma multiform line.

1988 • 101 citations

Cells resistant to interferon are defective in activation of a promoter-binding factor.

1988 • 83 citations

A DNA Binding Protein Regulated by IL-4 and by Differentiation in B Cells

1988 • 79 citations

Regulation of interleukin 2 receptor alpha subunit (Tac or CD25 antigen) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation.

1988 • 68 citations

Multiple Protein-DNA Interactions within the Human Interferon-β Regulatory Element

1989 • 47 citations

The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts.

1987 • 34 citations

Expression of human IFN-gamma genomic DNA in transgenic mice.

1989 • 28 citations