Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

1992 • 2,495 citations

Molecular Cloning of the Interleukin-1β Converting Enzyme

1992 • 1,115 citations

The molecular evolution of genes and proteins: a tale of two serines

1988 • 548 citations

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

1989 • 501 citations

Interleukin 1 is processed and released during apoptosis.

1991 • 459 citations

Pro-sequence of subtilisin can guide the refolding of denatured subtilisin in an intermolecular process

1989 • 345 citations

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor.

1987 • 342 citations

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha.

1991 • 324 citations

Activation of interleukin‐ 1β by a co‐induced protease

1989 • 254 citations

Expression of membrane interleukin 1 by fibroblasts transfected with murine pro-interleukin 1 alpha cDNA.

1988 • 171 citations

Protease pro region required for folding is a potent inhibitor of the mature enzyme

1992 • 116 citations

Role of the proregion in the production and secretion of the Yarrowia lipolytica alkaline extracellular protease

1991 • 63 citations

The insulin A and B chains contain sufficient structural information to form the native molecule

1991 • 49 citations

Generation of monoclonal antibodies to murine IL-1 beta and demonstration of IL-1 in vivo.

1991 • 44 citations

Antibodies of predetermined specificity to the major charged species of human interleukin 1.

1986 • 34 citations

Biologic and Immunohistochemical Analysis of Macrophage lnterleukin-1α, -1β, and Tumor Necrosis Factor Production During the Peritoneal Exudative Response

1989 • 19 citations