Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Nonparametric Statistical Methods

1999 • 6,387 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Flexible regression models with cubic splines

1989 • 2,398 citations

Clinical Applications of Research on Angiogenesis

1995 • 2,300 citations

The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing

1991 • 1,991 citations

Comparing Radical Mastectomy with Quadrantectomy, Axillary Dissection, and Radiotherapy in Patients with Small Cancers of the Breast

1981 • 1,581 citations

Clinical Cancer Research

1941 • 1,358 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 • 1,114 citations

Dangers of Using "Optimal" Cutpoints in the Evaluation of Prognostic Factors

1994 • 1,107 citations

Martingale-based residuals for survival models

1990 • 1,028 citations

Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor

1995 • 1,026 citations

Vascular permeability factor (VPF, VEGF) in tumor biology

1993 • 839 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

The pathology of invasive breast cancerA Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)

1975 • 755 citations

Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.

1994 • 680 citations

Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors.

1990 • 567 citations

Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas.

1993 • 564 citations

Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue.

1994 • 524 citations

Elevated Levels of an Angiogenic Peptide, Basic Fibroblast Growth Factor, in the Urine of Patients With a Wide Spectrum of Cancers

1994 • 478 citations

Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma.

1994 • 473 citations

Expression of Vascular Endothelial Growt Factor and Its Receptors fit and KDR in Ovarian Carcinoma

1995 • 469 citations

Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels.

1993 • 463 citations

Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool.

1995 • 441 citations

Association of Vascular Endothelial Growth Factor Expression with Tumor Angiogenesis and with Early Relapse in Primary Breast Cancer

1994 • 404 citations

The Prognosis of Carcinoma of the Breast in Relation to the Type of Operation Performed

1948 • 373 citations

Vascular endothelial growth factor

1996 • 360 citations

Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.

1996 • 351 citations

Delivery of Molecular Medicine to Solid Tumors

1996 • 314 citations

Cooperative effect of TNFalpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity.

1996 • 298 citations

Enhancement of Tumor Growth and Vascular Density by Transfection of Vascular Endothelial Cell Growth Factor Into MCF-7 Human Breast Carcinoma Cells

1995 • 270 citations

Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients.

1996 • 246 citations

Angiogenesis and breast cancer metastasis

1995 • 239 citations

Reciprocal paracrine interactions between tumour cells and endothelial cells: the ‘angiogenesis progression’ hypothesis

1996 • 212 citations

Upregulation of vascular endothelial growth factor (VEGF) and downregulation of placenta growth factor (PlGF) associated with malignancy in human thyroid tumors and cell lines.

1995 • 207 citations

Quantitative analysis of vascular endothelial growth factor in primary breast cancer

1996 • 199 citations

Vascular endothelial growth factor-toxin conjugate specifically inhibits KDR/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo.

1996 • 141 citations

Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer.

1995 • 122 citations

Association between tumour angiogenesis and tumour cell shedding into effluent venous blood during breast cancer surgery

1995 • 109 citations

Microvessel density and vessel invasion in lymph‐node‐negative breast cancer: Effect on recurrence‐free survival

1995 • 92 citations

Analysis of the tumor vasculature and metastatic behavior of xenografts of human melanoma cell lines transfected with vascular permeability factor.

1996 • 66 citations

Sensitive Chemiluminescence Enzyme Immunoassay for Vascular Endothelial Growth Factor/Vascular Permeability Factor in Human Serum

1995 • 47 citations

Angiogenesis research up to 1996. A commentary on the state of art and suggestions for future studies

1996 • 38 citations

Clinical studies with angiogenesis inhibitors: Biological rationale and challenges for their evaluation

1996 • 29 citations

Clinical applications of research on angiogenesis

1996 • 19 citations