The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade.

Angiogenesis in cancer, vascular, rheumatoid and other disease

1995 • 7,717 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

1996 • 4,143 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

1996 • 3,664 citations

Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders

1994 • 3,652 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

The fms -Like Tyrosine Kinase, a Receptor for Vascular Endothelial Growth Factor

1992 • 2,042 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 1,670 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins.

1995 • 1,280 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

1994 • 1,058 citations

Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor.

1991 • 999 citations

Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family.

1990 • 982 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

Endothelial receptor tyrosine kinases involved in angiogenesis.

1995 • 537 citations

Identification of a new endothelial cell growth factor receptor tyrosine kinase

1991 • 529 citations

A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.

1991 • 516 citations

Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors

1996 • 497 citations

A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF.

1995 • 480 citations

Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth.

1993 • 460 citations

Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

1996 • 406 citations

Role of Vegf-Flt Receptor System in Normal and Tumor Angiogenesis

1995 • 332 citations

Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis

1995 • 330 citations

FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines.

1992 • 285 citations

Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.

1993 • 262 citations

A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors.

1991 • 193 citations

The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor.

1993 • 164 citations

Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.

1994 • 163 citations

The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction

1995 • 160 citations

An immunoglobulin-like domain determines the specificity of neurotrophin receptors.

1995 • 151 citations

DNA looping between the origin of replication of Epstein-Barr virus and its enhancer site: stabilization of an origin complex with Epstein-Barr nuclear antigen 1.

1991 • 103 citations

Identification of a new endothelial cell growth factor receptor tyrosine kinase.

1991 • 101 citations

Molecular cloning of murine FLT and FLT4.

1993 • 90 citations

Chimeric alpha- and beta-platelet-derived growth factor (PDGF) receptors define three immunoglobulin-like domains of the alpha-PDGF receptor that determine PDGF-AA binding specificity.

1990 • 69 citations

Structural Role of Extracellular Domain 1 of α-Platelet-derived Growth Factor (PDGF) Receptor for PDGF-AA and PDGF-BB Binding

1995 • 27 citations

β PDGFR‐IgG chimera demonstrates that human β PDGFR Ig‐like domains 1 to 3 are sufficient for high affinity PDGF BB binding

1995 • 24 citations