Immunoadhesins: principles and applications

The Fas Death Factor

1995 • 4,070 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

Phage antibodies: filamentous phage displaying antibody variable domains

1990 • 2,346 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Reshaping human antibodies for therapy

1988 • 1,555 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.

1994 • 1,104 citations

The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

1995 • 704 citations

An endothelial ligand for L-Selectin is a novel mucin-like molecule

1992 • 660 citations

Binding of L-Selectin to the Vascular Sialomucin CD34

1993 • 629 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

CD30 antigen, a marker for Hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF

1993 • 541 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins

1995 • 381 citations

Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand.

1995 • 375 citations

Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF-α-Induced Angiogenesis

1995 • 368 citations

Antigen–specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

1994 • 351 citations

The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells

1991 • 348 citations

Molecular cloning of a ligand for the inducible T cell gene 4‐1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor

1993 • 328 citations

A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity.

1991 • 326 citations

Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor.

1991 • 308 citations

Influence of a recombinant human soluble tumor necrosis factor receptor FC fusion protein on type II collagen-induced arthritis in mice.

1993 • 298 citations

Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.

1994 • 284 citations

Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor

1993 • 280 citations

Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation

1995 • 261 citations

CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.

1993 • 243 citations

Suppression of the Immune Response by a Soluble Complement Receptor of B Lymphocytes

1991 • 242 citations

Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality

1991 • 239 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Biological properties of a CD4 immunoadhesin

1990 • 176 citations

Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation.

1995 • 171 citations

A soluble chimeric form of the L1 glycoprotein stimulates neurite outgrowth

1995 • 168 citations

A homing receptor-IgG chimera as a probe for adhesive ligands of lymph node high endothelial venules.

1990 • 162 citations

Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.

1994 • 157 citations

Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera.

1991 • 140 citations

A soluble multimeric recombinant CD2 protein identifies CD48 as a low affinity ligand for human CD2: divergence of CD2 ligands during the evolution of humans and mice.

1993 • 122 citations

Protective effects of selectin chimeras in neutrophil-mediated lung injury.

1993 • 122 citations

Characterization of Sialyloligosaccharide Binding by Recombinant Soluble and Native Cell-associated CD22

1995 • 119 citations

Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of interendothelial cell contacts.

1995 • 110 citations

Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides a costimulatory signal for T-cell receptor-initiated activation of human T cells.

1992 • 95 citations

Soluble forms of intercellular adhesion molecule-1 in insulin-dependent diabetes mellitus

1994 • 90 citations

VLA-4 integrin mediates lymphocyte migration on the inducible endothelial cell ligand VCAM-1 and the extracellular matrix ligand fibronectin.

1993 • 90 citations

Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules

1993 • 87 citations

CD2/LFA-3 ligation induces phospholipase-C gamma 1 tyrosine phosphorylation and regulates CD3 signaling.

1992 • 85 citations

Binding of Sialyl Lewis X to E-Selectin As Measured by Fluorescence Polarization

1995 • 79 citations

Anti-tumor antibody BR96 blocks cell migration and binds to a lysosomal membrane glycoprotein on cell surface microspikes and ruffled membranes.

1994 • 75 citations

Analysis of the Binding Site on Intercellular Adhesion Molecule 3 for the Leukocyte Integrin Lymphocyte Function-associated Antigen 1

1995 • 75 citations

Expression and characterization of hepatocyte growth factor receptor-IgG fusion proteins. Effects of mutations in the potential proteolytic cleavage site on processing and ligand binding.

1992 • 74 citations

Expression and Characterization of Human CD4: Immunoglobulin Fusion Proteins

1990 • 73 citations

Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule.

1994 • 70 citations

Specific receptor detection by a functional keratinocyte growth factor-immunoglobulin chimera.

1995 • 66 citations

Identification of cysteine-rich domains of the type 1 tumor necrosis factor receptor involved in ligand binding.

1992 • 61 citations

A chimeric IL-2/Ig molecule possesses the functional activity of both proteins.

1991 • 52 citations

The Disulfide Linkages and Glycosylation Sites of the Human Natriuretic Peptide Receptor-C Homodimer

1994 • 50 citations

The membrane distal half of gp130 is responsible for the formation of a ternary complex with IL‐6 and the IL‐6 receptor

1995 • 49 citations

Production of lymphotoxin (LTα) and a soluble dimeric form of its receptor using the baculovirus expression system

1994 • 45 citations

A receptor binding domain of mouse interleukin-4 defined by a solid-phase binding assay and in vitro mutagenesis.

1992 • 43 citations

Location of gp330/alpha 2-m receptor-associated protein (alpha 2-MRAP) and its binding sites in kidney: distribution of endogenous alpha 2-MRAP is modified by tissue processing.

1993 • 43 citations

Immunoadhesins

1993 • 41 citations

Human IgE receptor alpha-chain IgG chimera blocks passive cutaneous anaphylaxis reaction in vivo.

1993 • 38 citations

IFN-gamma receptor-Ig fusion proteins. Half-life, immunogenicity, and in vivo activity.

1992 • 38 citations

Phase 1 study of recombinant human CD4-immunoglobulin G therapy of patients with AIDS and AIDS-related complex

1991 • 37 citations

A Humanized, Bispecific Immunoadhesin-Antibody that Retargets CD3+ Effectors to Kill HIV-1-Infected Cells

1995 • 35 citations

Construction, purification, and characterization of new interferon gamma (IFN gamma) inhibitor proteins. Three IFN gamma receptor-immunoglobulin hybrid molecules.

1992 • 31 citations

Enzymic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments

1990 • 31 citations

A humanized, bispecific immunoadhesin-antibody that retargets CD3+ effectors to kill HIV-1-infected cells.

1994 • 30 citations

Soluble intercellular adhesion molecule 1-immunoglobulin G1 immunoadhesin mediates phagocytosis of malaria-infected erythrocytes.

1992 • 26 citations

HER4 Receptor Activation and Phosphorylation of Shc Proteins by Recombinant Heregulin-Fc Fusion Proteins

1995 • 25 citations

β PDGFR‐IgG chimera demonstrates that human β PDGFR Ig‐like domains 1 to 3 are sufficient for high affinity PDGF BB binding

1995 • 24 citations

TNF receptor fusion proteins are effective inhibitors of TNF-mediated cytotoxicity on human KYM-1D4 rhabdomyosarcoma cells

1994 • 23 citations

Inhibition of interferon-gamma by an interferon-gamma receptor immunoadhesin.

1993 • 17 citations

Generation of soluble interleukin-1 receptor from an immunoadhesin by specific cleavage

1994 • 16 citations

Identification of the T cell surface signal‐transducing glycoprotein sgp‐60 as CD48, a counter‐receptor for mouse CD2

1993 • 15 citations

Immunoadhesins: An Alternative to Human Monoclonal Antibodies

1995 • 14 citations

Molecular and biological properties of an interleukin-1 receptor immunoadhesin

1994 • 13 citations

Recombinant globulins: novel research tools and possible pharmaceuticals

1992 • 12 citations

Effects of Chemical Modification on the Binding Activities of P-Selectin Mutants

1995 • 11 citations

Bispecific receptor globulins, novel tools for the study of cellular interactions

1993 • 10 citations

Human erythropoietin-specific sites of monoclonal antibody-mediated neutralization

1993 • 9 citations

Recombinant CD4‐IgE, a novel hybrid molecule, inducing basophils to respond to human immunodeficiency virus (HIV) and HIV‐infected target cells

1995 • 6 citations

Coengagement of CD2 with LFA-1 or VLA-4 by bispecific ligand fusion proteins primes T cells to respond more effectively to T cell receptor-dependent signals

1994 • 5 citations