Review: On the Role of IRF in Host Defense

Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma

1994 • 5,605 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Kaposi's Sarcoma–Associated Herpesvirus-Like DNA Sequences in AIDS-Related Body-Cavity–Based Lymphomas

1995 • 2,833 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

IRF Family of Transcription Factors as Regulators of Host Defense

2001 • 1,566 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Viruses and interferon: a fight for supremacy

2002 • 1,335 citations

Distinct and Essential Roles of Transcription Factors IRF-3 and IRF-7 in Response to Viruses for IFN-α/β Gene Induction

2000 • 1,304 citations

Humoral Immunity Due to Long-Lived Plasma Cells

1998 • 1,223 citations

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

1998 • 1,040 citations

THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

1997 • 1,001 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

1996 • 926 citations

Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

1998 • 901 citations

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300

1998 • 812 citations

Type I Interferons Keep Activated T Cells Alive

1999 • 769 citations

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

1998 • 723 citations

Ordered Recruitment of Chromatin Modifying and General Transcription Factors to the IFN-β Promoter

2000 • 716 citations

Interferons α and β as Immune Regulators—A New Look

2001 • 671 citations

Type I Interferon as a Powerful Adjuvant for Monocyte-Derived Dendritic Cell Development and Activity in Vitro and in Hu-Pbl-Scid Mice

2000 • 650 citations

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

1998 • 602 citations

Activation of Interferon Regulatory Factor 3 Is Inhibited by the Influenza A Virus NS1 Protein

2000 • 580 citations

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

1993 • 507 citations

The growing family of interferon regulatory factors

1997 • 480 citations

A weak signal for strong responses: interferon-alpha/beta revisited

2001 • 471 citations

Interferon-γ: Biology and Role in Pathogenesis

1996 • 433 citations

Recruitment of CBP/p300 by the IFNβ Enhanceosome Is Required for Synergistic Activation of Transcription

1998 • 433 citations

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.

1992 • 430 citations

Structure of IRF-1 with bound DNA reveals determinants of interferon regulation

1998 • 385 citations

Kaposi's Sarcoma-Associated Herpesvirus Latent and Lytic Gene Expression as Revealed by DNA Arrays

2001 • 378 citations

Virus-specific Activation of a Novel Interferon Regulatory Factor, IRF-5, Results in the Induction of Distinct Interferon α Genes

2001 • 374 citations

Interferons and Other Cytokines

1997 • 364 citations

KSHV ORF K9 (vIRF) is an oncogene which inhibits the interferon signaling pathway

1997 • 358 citations

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1

1998 • 334 citations

The Mechanism of Transcriptional Synergy of an In Vitro Assembled Interferon-β Enhanceosome

1997 • 333 citations

The Interferon Genes

1986 • 304 citations

Kaposi's Sarcoma-Associated Herpesvirus LANA2 Is a B-Cell-Specific Latent Viral Protein That Inhibits p53

2001 • 298 citations

Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes

1998 • 295 citations

Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3

1998 • 278 citations

Selective DNA Binding and Association with the CREB Binding Protein Coactivator Contribute to Differential Activation of Alpha/Beta Interferon Genes by Interferon Regulatory Factors 3 and 7

2000 • 274 citations

Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription

1999 • 273 citations

Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3

1998 • 265 citations

Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the IFN‐β gene

1998 • 262 citations

IRF-7, a New Interferon Regulatory Factor Associated with Epstein-Barr Virus Latency

1997 • 253 citations

Multiple Regulatory Domains Control IRF-7 Activity in Response to Virus Infection

2000 • 233 citations

Human Herpesvirus 8 Encodes an Interferon Regulatory Factor (IRF) Homolog That Represses IRF-1-Mediated Transcription

1998 • 217 citations

Kaposi's Sarcoma–Associated Herpesvirus Immunoevasion and Tumorigenesis: Two Sides of the Same Coin?

2003 • 215 citations

Transcription Program of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus)

2001 • 213 citations

Functional Analysis of Human Herpesvirus 8-Encoded Viral Interferon Regulatory Factor 1 and Its Association with Cellular Interferon Regulatory Factors and p300

1999 • 211 citations

HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators

2001 • 208 citations

Regulated Nuclear-Cytoplasmic Localization of Interferon Regulatory Factor 3, a Subunit of Double-Stranded RNA-Activated Factor 1

2000 • 206 citations

Identification of Distinct Signaling Pathways Leading to the Phosphorylation of Interferon Regulatory Factor 3

2001 • 193 citations

Differential expression of human interferon genes

1984 • 184 citations

Characterization of a Novel Human Herpesvirus 8-Encoded Protein, vIRF-3, That Shows Homology to Viral and Cellular Interferon Regulatory Factors

2000 • 178 citations

Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

1997 • 162 citations

Regulation of the Promoter Activity of Interferon Regulatory Factor-7 Gene

2000 • 160 citations

Latently Expressed Human Herpesvirus 8-Encoded Interferon Regulatory Factor 2 Inhibits Double-Stranded RNA-Activated Protein Kinase

2001 • 157 citations

Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain

2000 • 142 citations

Identification of the rel Family Members Required for Virus Induction of the Human Beta Interferon Gene

1995 • 142 citations

Role of Natural Interferon-α Producing Cells (Plasmacytoid Dendritic Cells) in Autoimmunity

2003 • 138 citations

Stimulation of Interferon and Cytokine Gene Expression by Imiquimod and Stimulation by Sendai Virus Utilize Similar Signal Transduction Pathways

1995 • 137 citations

Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory Factor

2001 • 136 citations

Inhibition of p300 Histone Acetyltransferase by Viral Interferon Regulatory Factor

2000 • 135 citations

Protein-Protein and DNA-Protein Interactions Affect the Activity of Lymphoid-Specific IFN Regulatory Factors

1999 • 135 citations

Unique properties of a second human herpesvirus 8-encoded interferon regulatory factor (vIRF-2).

1999 • 126 citations

Natural Interferon-α Producing Cells: The Plasmacytoid Dendritic Cells

2002 • 122 citations

Different Relative Activities of Human Cell-Derived Interferon-α Subtypes: IFN-α8 Has Very High Antiviral Potency

1996 • 116 citations

The Histone Acetylase PCAF Is a Phorbol-Ester-Inducible Coactivator of the IRF Family That Confers Enhanced Interferon Responsiveness

1999 • 108 citations

Alternate interferon signaling pathways

2003 • 104 citations

Reconstitution of Virus-mediated Expression of Interferon α Genes in Human Fibroblast Cells by Ectopic Interferon Regulatory Factor-7

2000 • 98 citations

Type I interferons and T helper development

2000 • 98 citations

Three unrelated viral transforming proteins (vIRF, EBNA2, and E1A) induce the MYC oncogene through the interferon-responsive PRF element by using different transcription coadaptors

1999 • 91 citations

Molecular cloning and characterization of crucian carp (Carassius auratus L.) interferon regulatory factor 711The nucleotide sequence data reported in this paper has been submitted to the GenBank under accession number AY177629.

2003 • 90 citations

Analysis of Functional Domains of Interferon Regulatory Factor 7 and Its Association with IRF-3

2001 • 89 citations

Monocyte Differentiation to Macrophage Requires Interferon Regulatory Factor 7

2001 • 88 citations

Analyses of Virus-Induced Homomeric and Heteromeric Protein Associations between IRF-3 and Coactivator CBP/p300

2000 • 72 citations

Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors

2002 • 71 citations

Recruitment of Multiple Interferon Regulatory Factors and Histone Acetyltransferase to the Transcriptionally Active Interferon A Promoters

2001 • 58 citations

Human Type I Interferons Differ Greatly in Their Effects on the Proliferation of Primary B Cells

1999 • 52 citations

Virus-mediated induction of interferon A gene requires cooperation between multiple binding factors in the interferon alpha promoter region.

1993 • 50 citations

Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor Confers Resistance to the Antiproliferative Effect of Interferon-α

1998 • 50 citations

Potential Mechanisms of Interferon-α Induced Autoimmunity

2003 • 49 citations

Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Binds to, and Inhibits Transactivation of, CREB-Binding Protein

2000 • 47 citations

Differential and cell type specific expression of murine alpha-interferon genes is regulated on the transcriptional level

1988 • 41 citations

The human type I interferon gene cluster

1995 • 38 citations

The Cell Cycle Control Element of Histone H4 Gene Transcription Is Maximally Responsive to Interferon Regulatory Factor Pairs IRF-1/IRF-3 and IRF-1/IRF-7

2001 • 37 citations

The Epstein-Barr virus EBNA-1 promoter Qp requires an initiator-like element

1997 • 33 citations

Downregulation of IRF-3 Levels by Ribozyme Modulates the Profile of IFNA Subtypes Expressed in Infected Human Cells

2001 • 32 citations

Induction of interferon alpha genes expression

1995 • 31 citations

Silencer Activity in the Interferon-A Gene Promoters

1997 • 29 citations

Construction of a Physical and Transcript Map Flanking the Imprinted MEST/PEG1 Region at 7q32

2000 • 29 citations

Lipopolysaccharide Inhibits Virus-mediated Induction of Interferon Genes by Disruption of Nuclear Transport of Interferon Regulatory Factors 3 and 7

1999 • 23 citations

Repression of Virus-Induced Interferon A Promoters by Homeodomain Transcription Factor Ptx1

2000 • 19 citations

Relative Transcriptional Inducibility of the Human Interferon-α Subtypes Conferred by the Virus-Responsive Enhancer Sequence

1996 • 17 citations