Phosphorylation-Induced Dimerization of Interferon Regulatory Factor 7 Unmasks DNA Binding and a Bipartite Transactivation Domain

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

1998 • 1,040 citations

Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

1989 • 970 citations

Virus-Dependent Phosphorylation of the IRF-3 Transcription Factor Regulates Nuclear Translocation, Transactivation Potential, and Proteasome-Mediated Degradation

1998 • 901 citations

STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

1999 • 885 citations

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300

1998 • 812 citations

Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen.

1990 • 772 citations

Virus Infection Induces the Assembly of Coordinately Activated Transcription Factors on the IFN-β Enhancer In Vivo

1998 • 723 citations

Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity

1998 • 602 citations

A vector for expressing GAL4(1–147) fusions tn mammalian cells

1989 • 558 citations

Positive feedback regulation of type I IFN genes by the IFN‐inducible transcription factor IRF‐7

1998 • 546 citations

The growing family of interferon regulatory factors

1997 • 480 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor

1988 • 427 citations

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins.

1992 • 387 citations

Structure of IRF-1 with bound DNA reveals determinants of interferon regulation

1998 • 385 citations

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

1993 • 374 citations

TRANSCRIPTION ACTIVATION BY ESTROGEN AND PROGESTERONE RECEPTORS

1991 • 372 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

Ras-Independent Growth Factor Signaling by Transcription Factor Tyrosine Phosphorylation

1993 • 345 citations

Interferon Regulatory Factor 3 and CREB-Binding Protein/p300 Are Subunits of Double-Stranded RNA-Activated Transcription Factor DRAF1

1998 • 334 citations

Interferon-alpha regulates nuclear translocation and DNA-binding affinity of ISGF3, a multimeric transcriptional activator.

1990 • 321 citations

Structural and Functional Analysis of Interferon Regulatory Factor 3: Localization of the Transactivation and Autoinhibitory Domains

1999 • 319 citations

Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors.

1992 • 314 citations

Characterization of the Interferon Regulatory Factor-7 and Its Potential Role in the Transcription Activation of Interferon A Genes

1998 • 295 citations

Regulation of Type I Interferon Gene Expression by Interferon Regulatory Factor-3

1998 • 278 citations

Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription

1999 • 273 citations

Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3

1998 • 265 citations

Involvement of the IRF family transcription factor IRF‐3 in virus‐induced activation of the IFN‐β gene

1998 • 262 citations

Signal transduction by steroid hormones: nuclear localization is differentially regulated in estrogen and glucocorticoid receptors.

1990 • 257 citations

Virus Infection Leads to Localized Hyperacetylation of Histones H3 and H4 at the IFN-β Promoter

1999 • 251 citations

Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

1996 • 237 citations

Regulated Nuclear-Cytoplasmic Localization of Interferon Regulatory Factor 3, a Subunit of Double-Stranded RNA-Activated Factor 1

2000 • 206 citations

Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences

1999 • 206 citations

Activation of IFN-βelement by IRF-1 requires a post-translational event in addition to IRF-1 synthesis

1991 • 201 citations

Assembly requirements of PU.1–Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers

1999 • 190 citations

Interferon-β is required for interferon-α production in mouse fibroblasts

1998 • 173 citations

Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

1997 • 162 citations

Cytomegalovirus Activates Interferon Immediate-Early Response Gene Expression and an Interferon Regulatory Factor 3-Containing Interferon-Stimulated Response Element-Binding Complex

1998 • 158 citations

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

1995 • 150 citations

Protein-Protein and DNA-Protein Interactions Affect the Activity of Lymphoid-Specific IFN Regulatory Factors

1999 • 135 citations

Constitutive expression of an ISGF2/IRF1 transgene leads to interferon-independent activation of interferon-inducible genes and resistance to virus infection

1992 • 133 citations

Two Domains of ISGF3γ That Mediate Protein-DNA and Protein-Protein Interactions during Transcription Factor Assembly Contribute to DNA-Binding Specificity

1993 • 124 citations

Functional Domain Analysis of Interferon Consensus Sequence Binding Protein (ICSBP) and Its Association with Interferon Regulatory Factors

1995 • 99 citations

Reconstitution of Virus-mediated Expression of Interferon α Genes in Human Fibroblast Cells by Ectopic Interferon Regulatory Factor-7

2000 • 98 citations

Interferon regulatory factors: growth control and histone gene regulation - it's not just interferon anymore

1997 • 94 citations

Functional domains of interferon regulatory factor I (IRF-1)

1998 • 92 citations

Characterization of a mouse interferon gene locus I. Isolation of a cluster of four α-interferon genes

1985 • 82 citations

Two domains of ISGF3 gamma that mediate protein-DNA and protein-protein interactions during transcription factor assembly contribute to DNA-binding specificity.

1993 • 71 citations

Design of Conditionally Active STATs: Insights into STAT Activation and Gene Regulatory Function

1999 • 53 citations

Cooperativity and Dimerization of Recombinant Human Estrogen Receptor Hormone-binding Domain

1997 • 51 citations

A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene.

1994 • 33 citations

A conditionally active form of STAT6 can mimic certain effects of IL-4.

1998 • 27 citations

Solution structure of the IRF-2 DNA-binding domain: a novel subgroup of the winged helix–turn–helix family

1998 • 24 citations

Cutting Edge: A Conditionally Active Form of STAT6 Can Mimic Certain Effects of IL-4

1998 • 22 citations

In vivo formation of IRF-1 homodimers

1998 • 20 citations

Analysis of Interferon-Regulated Proteins Binding the Interferon-α-Stimulated Response Element

1998 • 18 citations