Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

A TH1→TH2 switch is a critical step in the etiology of HIV infection

1993 • 1,403 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

1988 • 939 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

1992 • 794 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

A solid-phase immunoenzymatic technique for the enumeration of specific antibody-secreting cells

1983 • 561 citations

Leukocyte Interferon-Induced Tumor Regression in Human Metastatic Breast Cancer, Multiple Myeloma, and Malignant Lymphoma

1980 • 503 citations

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.

1992 • 430 citations

Interferons and other regulatory cytokines

1988 • 429 citations

Recombinant Leukocyte A Interferon: Pharmacokinetics, Single-Dose Tolerance, and Biologic Effects in Cancer Patients

1982 • 381 citations

Murine Th1 and Th2 clones proliferate optimally in response to distinct antigen-presenting cell populations.

1991 • 355 citations

IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma.

1988 • 315 citations

Regulation and deregulation of human IgE synthesis

1990 • 254 citations

Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells.

1989 • 228 citations

Regulation by interferon alpha of immunoglobulin isotype selection and lymphokine production in mice.

1991 • 193 citations

A human 15-kDa IFN-induced protein induces the secretion of IFN-gamma.

1991 • 168 citations

Simultaneous production of interleukin 2, interleukin 4 and interferon‐γ by activated human blood lymphocytes

1990 • 165 citations

Comparison of the Antiviral Activities of Various Cloned Human Interferon- Subtypes in Mammalian Cell Cultures

1981 • 164 citations

Evidence that defective interferon-gamma production in dermatitis patients is due to intrinsic abnormalities

1990 • 137 citations

Cytokine secretion patterns and cross-regulation of T cell subsets

1991 • 127 citations

Interferons in the Persistence, Pathogenesis, and Treatment of HIV Infection

1992 • 123 citations

Bee venom phospholipase A2‐specific T cell clones from human allergic and non‐allergic individuals: cytokine patterns change in response to the antigen concentration

1992 • 114 citations

Biological Activities and Receptor Binding of Two Human Recombinant Interferons and their Hybrids

1986 • 83 citations

Interferon-α for the Hypereosinophilic Syndrome

1990 • 75 citations

A Recombinant Human Interferon- B/D Hybrid with a Broad Host-range

1987 • 74 citations

Enumeration of IFN-γ-producing human lymphocytes by spot-ELISA

1988 • 70 citations

Expression, renaturation and purification of recombinant human interleukin 4 from Escherichia coli

1988 • 62 citations

α-Interferon therapy of chronic hepatitis B. Current status and recommendations

1990 • 46 citations

T Cell-Dependent Differentiation of Human B Cells into IgM, IgG, IgA, or IgE Plasma Cells: High Rate of Antibody Production by IgE Plasma Cells, but Limited Clonal Expansion of IgE Precursors

1993 • 38 citations

Cytokines: is there biological meaning?

1991 • 36 citations

Interferon alpha (IFN)-Macrophage Interactions in Human Immunodeficiency Virus (HIV) Infection: Role of IFN in the Tempo and Progression of HIV Disease

1992 • 20 citations

Interleukin 4 inhibits the interleukin 2-induced production of its functional antagonist, interferon gamma

1989 • 19 citations

T cell dependent differentiation of human B cells: Direct switch from Igm to IgE, and sequential switch from Igm via IgG to IgA production

1992 • 16 citations

Interferon-α Suppresses the Capacity of T Cells to Help Antibody Production by Human B Cells

1992 • 13 citations

Regulation of the development of helper T cell subsets

1991 • 3 citations