Interferons α and β as Immune Regulators—A New Look

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood

1999 • 2,255 citations

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

1999 • 2,128 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

1999 • 1,754 citations

Natural adjuvants: Endogenous activators of dendritic cells

1999 • 1,611 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

1998 • 1,040 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Interleukin 15: biology and relevance to human disease

2001 • 947 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA

1999 • 727 citations

Type I Interferon as a Powerful Adjuvant for Monocyte-Derived Dendritic Cell Development and Activity in Vitro and in Hu-Pbl-Scid Mice

2000 • 650 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

Interferon alpha increases the frequency of interferon gamma-producing human CD4+ T cells.

1993 • 507 citations

Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection.

1996 • 413 citations

Interferons and Other Cytokines

1997 • 364 citations

Regulation of c-myc expression by IFN-γ through Stat1-dependent and -independent pathways

2000 • 314 citations

Roles of IFN-gamma and IFN-alpha in IL-12-induced T helper cell-1 development.

1996 • 313 citations

Differential Regulation of Human Blood Dendritic Cell Subsets by IFNs

2001 • 311 citations

Interferon-α/β inhibition of interleukin 12 and interferon-γ productionin vitroand endogenously during viral infection

1997 • 303 citations

The Role of Stat4 in Species-Specific Regulation of Th Cell Development by Type I IFNs

1998 • 300 citations

Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection

1999 • 299 citations

Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox

2000 • 293 citations

Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.

1996 • 281 citations

Type I IFN Modulates Innate and Specific Antiviral Immunity

2000 • 276 citations

Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells.

1998 • 272 citations

Primary activation of interferon A and interferon B gene transcription by interferon regulatory factor 3

1998 • 265 citations

Type I IFNs Inhibit Human Dendritic Cell IL-12 Production and Th1 Cell Development

1998 • 264 citations

Influenza A Virus-Induced IFN-α/β and IL-18 Synergistically Enhance IFN-γ Gene Expression in Human T Cells

1998 • 218 citations

Distinct Requirements for IFNs and STAT1 in NK Cell Function

2000 • 214 citations

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

2000 • 190 citations

IFN-α and IL-12 Induce IL-18 Receptor Gene Expression in Human NK and T Cells

2000 • 169 citations

Lineage-specific Requirement for Signal Transducer and Activator of Transcription (Stat)4 in Interferon γ Production from CD4+ Versus CD8+ T Cells

1999 • 168 citations

Polyinosinic acid: polycytidylic acid promotes T helper type 1‐specific immune responses by stimulating macrophage production of interferon‐α and interleukin‐12

1995 • 137 citations

The mannose receptor mediates induction of IFN-alpha in peripheral blood dendritic cells by enveloped RNA and DNA viruses.

1998 • 132 citations

The Mannose Receptor Mediates Induction of IFN-α in Peripheral Blood Dendritic Cells by Enveloped RNA and DNA Viruses

1998 • 100 citations

IFN-alpha priming of human monocytes differentially regulates gram-positive and gram-negative bacteria-induced IL-10 release and selectively enhances IL-12p70, CD80, and MHC class I expression.

1998 • 85 citations

Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression

1997 • 82 citations

IFN-α Priming of Human Monocytes Differentially Regulates Gram-Positive and Gram-Negative Bacteria-Induced IL-10 Release and Selectively Enhances IL-12p70, CD80, and MHC Class I Expression

1998 • 71 citations

IFN-alpha and IL-18 exert opposite regulatory effects on the IL-12 receptor expression and IL-12-induced IFN-gamma production in mouse macrophages: novel pathways in the regulation of the inflammatory response of macrophages.

2000 • 50 citations

IFN-α and IL-18 exert opposite regulatory effects on the IL-12 receptor expression and IL-12-induced IFN-γ production in mouse macrophages: novel pathways in the regulation of the inflammatory response of macrophages

2000 • 37 citations