The Non-Antiemetic Uses of Serotonin 5-HT3 Receptor Antagonists

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

1987 • 866 citations

Molecular biology of 5-HT receptors

1994 • 679 citations

5-HT3 receptors are membrane ion channels

1989 • 630 citations

5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research

1995 • 497 citations

Comparison of the 5-Hydroxytryptamine₃(Serotonin) Antagonist Ondansetron (Gr 38032F) with High-Dose Metoclopramide in the Control of Cisplatin-Induced Emesis

1990 • 409 citations

Effects of the 5‐HT₃ receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain

1987 • 354 citations

5-HT and alcohol abuse

1992 • 327 citations

Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics

1995 • 276 citations

CCK in animal and human research on anxiety

1993 • 272 citations

5-HT3 receptors mediate inhibition of acetylcholine release in cortical tissue

1989 • 259 citations

Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA

1991 • 259 citations

The psychopharmacology of 5-HT3 receptors

1990 • 246 citations

Randomized, Placebo-Controlled Evaluation of Prochlorperazine Versus Metoclopramide for Emergency Department Treatment of Migraine Headache

1995 • 223 citations

Effects of 5-HT3 receptor antagonism on hippocampal theta rhythm, memory, and LTP induction in the freely moving rat

1995 • 219 citations

Parameters of self-administration of cocaine in rats under a progressive-ratio schedule

1993 • 217 citations

Psychosis in advanced Parkinson's disease

1995 • 193 citations

Clinical Efficacy of the 5‐HT₃ Antagonist Ondansetron in Alcohol Abuse and Dependence

1994 • 192 citations

1-(m-Chlorophenyl)-biguanide, a potent high affinity 5-HT3 receptor agonist

1990 • 188 citations

Reduction of rectal sensitivity and post‐prandial motility by granisetron, a 5 HT₃‐receptor antagonist, in patients with irritable bowel syndrome

1993 • 186 citations

5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord

1989 • 184 citations

The 5-HT3 Receptor Channel

1995 • 180 citations

Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.

1995 • 179 citations

5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward

1989 • 176 citations

Serotonin, schizophrenia and antipsychotic drug action

1995 • 172 citations

Quantitative autoradiographic mapping of 5‐HT₃ receptors in the rat CNS using [¹²⁵I]iodo‐zacopride and [³H]zacopride as radioligands

1992 • 165 citations

Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety

1993 • 159 citations

5-HT3 receptors control dopamine release in the nucleus accumbens of freely moving rats

1989 • 153 citations

The 5‐HT₄ Receptor

1993 • 145 citations

5-HT3 Receptor Antagonists

1991 • 138 citations

5-HT3 receptors modulate spinal nociceptive reflexes

1990 • 132 citations

Behavioural pharmacology of 5-HT3 receptor antagonists: a critical update on therapeutic potential

1993 • 131 citations

Electrophysiological, biochemical and behavioral evidence for 5-HT2 and 5-HT3 mediated control of dopaminergic function

1993 • 125 citations

Localization of 5-HT3 receptors in the rat brain using [3H]LY278584

1991 • 117 citations

Effect of the 5-HT3 receptor antagonist, GR38032F, on responses to injection of a neurokinin agonist into the ventral tegmental area of the rat brain

1987 • 113 citations

5‐Hydroxytryptamine₃ Receptors Sited on Cholinergic Axon Terminals of Human Cerebral Cortex Mediate Inhibition of Acetylcholine Release

1992 • 113 citations

The role of 5-HT3 receptors in drug dependence

1995 • 112 citations

Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

1989 • 109 citations

Serotonergic Facilitation of Acetylcholine Release In Vivo from Rat Dorsal Hippocampus via Serotonin 5‐HT₃ Receptors

1994 • 106 citations

Selective 5-Hydroxytryptamine Type 3 Receptor Antagonism With Ondansetron as Treatment for Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Study

1992 • 106 citations

The novel antipsychotic drugs.

2002 • 101 citations

Localization of 5-HT3 receptors in the rat spinal cord

1995 • 101 citations

Cholecystokinin release mediated by 5‐HT₃ receptors in rat cerebral cortex and nucleus accumbens

1991 • 97 citations

β-adrenergic receptors are involved in stress-related behavioral changes

1993 • 94 citations

5-HT3 receptor antagonists attenuate cocaine-induced locomotion in mice

1990 • 93 citations

Effect of a 5HT₃‐antagonist (ondansetron) on rectal sensitivity and compliance in health and the irritable bowel syndrome

1993 • 93 citations

Effect of drugs influencing 5-HT function on ethanol drinking and feeding behaviour in rats: Studies using a drinkometer system

1992 • 92 citations

Effect of acute and chronic MDL 73,147EF, a 5-HT3 receptor antagonist, on A9 and A10 dopamine neurons

1989 • 91 citations

Effect of the 5-HT3 receptor antagonists, MDL72222 and ondansetron on morphine place conditioning

1992 • 86 citations

SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo

1993 • 85 citations

Evidence that the amygdala is involved in the disinhibitory effects of 5-HT3 receptor antagonists

1991 • 84 citations

5-HT3 receptor antagonists inhibit morphine-induced stimulation of mesolimbic dopamine release and function in the rat

1993 • 81 citations

A randomized double-blind placebo-controlled study of tropisetron in the treatment of outpatients with generalized anxiety disorder

1993 • 81 citations

The effect of ondansetron on cognitive performance in the marmoset

1991 • 79 citations

GR38032F, a serotonin 5-HT3 antagonist, fails to alter cocaine self-administration in rats

1991 • 77 citations

A Placebo-controlled Inpatient Comparison of Fluvoxamine Maleate and Imipramine in Major Depression

1989 • 77 citations

Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5HT1, 5HT2 and 5HT3 receptors

1989 • 74 citations

Pharmacological mechanisms and animal models of cognition

1992 • 71 citations

BRL 46470A: a highly potent, selective and long acting 5-HT3 receptor antagonist with anxiolytic-like properties

1993 • 70 citations

New animal models of anxiety

1994 • 69 citations

Failure of ondansetron to block the discriminative or reinforcing stimulus effects of cocaine in the rat

1992 • 66 citations

Local 5HT3 receptors mediate fluoxetine but not desipramine-induced increase of extracellular dopamine in the prefrontal cortex

1995 • 66 citations

5‐HT₃ Receptors: Pharmacologic and Therapeutic Aspects

1995 • 66 citations

MDL 72222, ketanserin, and methysergide pretreatments fail to alter breaking points on a progressive ratio schedule reinforced by intravenous cocaine

1993 • 65 citations

Functional characterization of a 5‐HT₃ receptor which modulates the release of 5‐HT in the guinea‐pig brain

1993 • 64 citations

Reversal of neuroleptic-induced catalepsy by novel aryl-piperazine anxiolytic drugs

1988 • 62 citations

The abilities of 5-HT3 receptor antagonist ICS 205-930 to inhibit alcohol preference and withdrawal seizures in rats

1993 • 60 citations

Ondansetron improves cognitive performance in the Morris water maze spatial navigation task

1995 • 59 citations

The 5-HT3 receptor antagonist zatosetron decreases the number of spontaneously active A10 dopamine neurons

1991 • 58 citations

MDL72222, a serotonin 5-HT3 receptor antagonist, blocks MDMA's ability to establish a conditioned place preference

1991 • 58 citations

Effects of antidepressants on the inward current mediated by 5‐HT₃ receptors in rat nodose ganglion neurones

1994 • 58 citations

Interactions between 5-HT3 receptors and cerebral dopamine function: implications for the treatment of schizophrenia and psychoactive substance abuse

1993 • 57 citations

A multicentre double‐blind comparative trial of fluvoxamine versus lorazepam in mixed anxiety and depression treated in general practice

1990 • 57 citations

Recent advances in the treatment of neurodegenerative disorders and cognitive dysfunction

1995 • 57 citations

Activation of 5-HT3 receptors enhances the electrically evoked release of [3H]noradrenaline in rat brain limbic structures

1994 • 56 citations

Investigation of the role of 5‐HT₃ and 5‐HT₄ receptors in ascending and descending reflexes to the circular muscle of guinea‐pig small intestine

1994 • 56 citations

The selective 5-HT3 receptor antagonist, WAY100289, enhances spatial memory in rats with ibotenate lesions of the forebrain cholinergic projection system

1995 • 56 citations

Serotonin 5-HT3 antagonists do not alter the discriminative stimulus properties of cocaine

1991 • 55 citations

Metoclopramide

1991 • 55 citations

Interaction between enantiomers of mianserin and ORG3770 at 5-HT3 receptors in cultured mouse neuroblastoma cells

1994 • 55 citations

Influence of 5-HT3 receptor antagonists and the indirect 5-HT agonist, dexfenfluramine, on heroin self-administration in rats

1994 • 54 citations

Nicotine self-administration and locomotor activity are not modified by the 5-HT3 antagonists ICS 205–930 and MDL 72222

1994 • 53 citations

The Psychopharmacology of 5‐HT₃ Receptors^*

1992 • 52 citations

Differences between 5‐HT₃ receptor antagonists in modulation of visceral hypersensitivity

1995 • 51 citations

Effects of the 5-HT3 antagonist GR38032F (ondansetron) on benzodiazepine withdrawal in rats

1990 • 51 citations

Analgesic action of metoclopramide in prosthetic hip surgery

1993 • 51 citations

Effects of DAU 6215, a novel 5‐hydroxytryptamine₃ (5‐HT₃) antagonist on electrophysiological properties of the rat hippocampus

1994 • 50 citations

[3H]ICS 205-930 labels 5-HT3 recognition sites in membranes of cat and rabbit vagus nerve and superior cervical ganglion

1989 • 50 citations

The interaction of antidepressant drugs with central and peripheral (enteric) 5‐HT₃ and 5‐HT₄ receptors

1995 • 48 citations

Serotonin3 receptor antagonists block anorectic responses to amino acid imbalance

1990 • 47 citations

Behavioural studies on WAY100289, a novel 5-HT3 receptor antagonist, in two animal models of anxiety

1992 • 45 citations

Effects on Migraine Headache of MDL 72,222, an Antagonist at Neuronal 5-HT Receptors. Double-Blind, Placebo-Controlled Study

1985 • 44 citations

Preclinical anxiolytic versus antipsychotic profiles of the 5‐HT₃ antagonists ondansetron, zacopride, 3α‐tropanyl‐1H‐indole‐3‐carboxylic acid ester, and 1αH, 3α, 5αH‐tropan‐3‐yl‐3,5‐dichlorobenzoate

1991 • 44 citations

Blockade of acquisition of drug-conditioned place aversion by 5HT3 antagonists

1990 • 44 citations

Spinal supersensitivity to 5-HT1, 5-HT2 and 5-HT3 receptor agonists following 5,7-dihydroxytryptamine

1994 • 42 citations

Antagonists at the serotonin-3 receptor can reduce the fear-potentiated startle response in the rat: evidence for different types of anxiolytic activity?

1994 • 41 citations

Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task

1994 • 41 citations

Ondansetron, a 5-HT3 receptor antagonist, partially attenuates the effects of amphetamine

1992 • 41 citations

Reduced levels of 5-HT3 receptor recognition sites in the putamen of patients with Huntington's disease

1993 • 41 citations

Serotonin 5-HT3 antagonists fail to affect ethanol self-administration of rats

1994 • 41 citations

Litoxetine: a selective 5-HT uptake inhibitor with concomitant 5-HT3 receptor antagonist and antiemetic properties

1993 • 38 citations

Influence of 5‐HT₃ receptor antagonists in visceromotor and nociceptive responses to rectal distension before and during experimental colitis in rats*

1994 • 37 citations

Vagal afferent-mediated inhibition of a nociceptive reflex by i.v. serotonin in the rat. II. Role of 5-HT receptor subtypes

1992 • 37 citations

Effects of 5-HT3 receptor antagonists on neuroleptic-induced catalepsy in mice

1995 • 36 citations

Central action of 5-HT3 receptor ligands in the regulation of sleep-wakefulness and raphe neuronal activity in the rat

1992 • 35 citations

Inhibition of a 5-HT3 receptor-mediated current by the selective serotonin uptake inhibitor, fluoxetine

1994 • 35 citations

Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents

1995 • 35 citations

Effect of serotonergic agonists in the nucleus accumbens on d-amphetamine-stimulated locomotion

1992 • 35 citations

Identification and distribution of 5‐HT₃ recognition sites in the rat gastrointestinal tract

1992 • 34 citations

5-HT3 receptor ligands lack modulatory influence on acetycholine release in rat entorhinal cortex

1993 • 32 citations

8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition

1990 • 32 citations

The 5-HT3 antagonist, BRL 46470 does not attenuate m-chlorophenylpiperazine (mCPP)-induced changes in human volunteers

1994 • 31 citations

Evidence that the atypical 5‐HT₃ receptor ligand, [³H]‐BRL46470, labels additional 5‐HT₃ binding sites compared to [³H]‐granisetron

1995 • 30 citations

5‐HT₃ receptor agonist induced carrier‐mediated release of dopamine in rat striatum in vivo

1995 • 30 citations

Ondansetron, a selective 5-HT3 receptor antagonist, reduces palatable food consumption in the nondeprived rat

1994 • 30 citations

Effects of 5-hydroxytryptamine3 antagonist, ondansetron, on cigarette smoking, smoke exposure, and mood in humans

1993 • 30 citations

The effect of a 5-HT3 receptor antagonist, ondansetron, on brain stimulation reward, and its interaction with direct and indirect stimulants of central dopaminergic transmission

1993 • 30 citations

A Double-Blind Comparison of Granisetron and Placebo for the Treatment of Acute Migraine in The Emergency Department

1991 • 30 citations

The 5-HT3 Antagonist MDL-72222 Exacerbates Ethanol Withdrawal Seizures in Mice

1994 • 29 citations

Effects of acute administration of the 5-HT3 receptor antagonist, BRL 46470A, on the behaviour of mice in a two compartment light-dark box and during social interactions in their home cage and an unfamiliar neutral cage

1992 • 29 citations

Enhancement of Memory Retrieval and Attenuation of Scopolamine‐Induced Amnesia Following Administration of 5‐HT₃ Antagonist ICS 205‐930

1991 • 29 citations

Effects of 8-OH-DPAT, buspirone and ICS 205-930 on feeding in a novel environment: comparisons with chlordiazepoxide and FG 7142

1990 • 29 citations

5‐HT₃ antagonists reduce morphine self‐administration in rats

1993 • 28 citations

Efficacy of ICS 205-930, a novel 5-hydroxytryptamine3 (5-HT3) receptor antagonist, in the prevention of migraine attacks. A complex answer to a simple question

1991 • 28 citations

The effect of 5-HT3 receptor antagonists on the discriminative stimulus effects of amphetamine

1992 • 28 citations

Effects of ondansetron pretreatment on acute responses to ethanol in social drinkers

1994 • 28 citations

Chronic BRL 43694, a selective 5-HT3 receptor antagonist, fails to alter the number of spontaneously active midbrain dopamine neurons

1990 • 28 citations

Serotonin 5-HT3 receptors in schizophrenia: a postmortem study of the amygdala

1993 • 28 citations

5HT3 receptor antagonists do not block nicotine induced hyperactivity in rats

1995 • 27 citations

Naloxone and serotonin receptor subtype antagonists: Interactive effects upon deprivation-induced intake

1991 • 27 citations

Constipation Evoked by 5-HT3-Receptor Antagonism: Evidence for Heterogeneous Efficacy among Different Antagonists in Guinea-pigs

1994 • 26 citations

Effects of chronic administration of ondansetron (GR38032F), a selective 5-HT3 receptor antagonist, on monoamine metabolism in mesolimbic and nigrostriatal dopaminergic neurons and on striatal D2-receptor binding

1990 • 26 citations

5-HT3 receptors antagonists block morphine- and nicotine- but not amphetamine-induced place-preference conditioning

1988 • 26 citations

Similar effects of diazepam and the 5-HT3 receptor antagonist ICS 205-930 on place aversion conditioning

1988 • 26 citations

Alcohol‐induced reinforcement: Dopamine and 5‐HT₃ receptor interactions in animals and humans

1993 • 26 citations

Alcohol drinking in rats treated with 5,7-dihydroxytryptamine: Effect of 8-OH-DPAT and tropisetron (ICS 205-930)

1994 • 25 citations

DAU 6215, a novel 5-HT3-receptor antagonist, selectively antagonizes scopolamine-induced deficit in a passive-avoidance task, but not scopolamine-induced hypermotility in rats

1993 • 25 citations

First Clinical Study of the Selective 5‐HT₃ Antagonist, Granisetron (BRL 43694), in the Acute Treatment of Migraine Headache

1991 • 24 citations

Effect of 5-HT3 receptor antagonists on the discriminative stimulus properties of morphine in rats

1993 • 24 citations

Anorectic response to amino acid imbalance: A selective serotonin3 effect?

1994 • 24 citations

Serotonin receptors and therapeutics.

1994 • 23 citations

Ondansetron and Opiate Craving

1995 • 22 citations

Normal densities of 5-HT3 receptor recognition sites in Alzheimerʼs disease

1990 • 22 citations

5-HT3 Receptor antagonists. 3. Quinoline derivatives which may be effective in the therapy of irritable bowel syndrome

1993 • 21 citations

5-HT3 receptors and the therapeutic potential of 5-HT3 receptor antagonists.

1991 • 21 citations

Differentiation Alters the Expression of the Two Splice Variants of the Serotonin 5‐HT₃ Receptor‐A mRNA in NG108‐15 Cells

1995 • 20 citations

Allosteric Interactions Among Agonists and Antagonists at 5‐Hydroxytryptamine₃ Receptors

1995 • 19 citations

The effect of drugs interacting with serotonergic 5HT3 and 5HT4 receptors on morphine place conditioning.

1993 • 19 citations

Section Review Central & Peripheral Nervous Systems: 5-HT₃receptor antagonists

1996 • 17 citations

Ondansetron fails to attenuate a scopolamineinduced deficit in a Stone maze task

1994 • 17 citations

5-HT3 agonist-induced dopamine overflow during withdrawal from continuous or intermittent cocaine administration

1995 • 16 citations

Differential effects of ondansetron, haloperidol and clozapine on electrical self-stimulation of the ventral tegmental area

1993 • 16 citations

Non-reversal of scopolamine- or age-related EEG changes by ondansetron, methysergide or alaproclate

1991 • 16 citations

Lack of effects of 5-HT3 antagonists on normal and morphine-attenuated sexual behaviours in female and male rats

1993 • 15 citations

Zatosetron, a 5-HT3 receptor antagonist in a multicenter trial for acute migraine

1994 • 15 citations

Effects of 5-HT3 agonists on reproductive behaviors in rats

1994 • 15 citations

Intrathecal 5-methoxy-N, N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors

1993 • 15 citations

Effect of the 5-hydroxytryptamine3 receptor antagonist itasetron (DAU 6215) on (+)-N-allylnormetazocine-induced dopamine release in the nucleus accumbens and in the corpus striatum of the rat: an in vivo microdialysis study.

1995 • 15 citations

An overview of fluoxetine, a new serotonin-specific antidepressant.

1989 • 15 citations

Ethanol- and diazepam-withdrawal hyperlocomotion is not due to 5-HT3 receptor stimulation

1993 • 15 citations

New anxiolytics in development.

1993 • 15 citations

Comparative involvement of 5-HT1, 5-H2 and 5-HT3 receptors in stress-induced colonic motor alterations in rats

1993 • 15 citations

Effect of the 5-HT3 receptor antagonist ondansetron on hypothalamic self-stimulation in rats and its interaction with the CCK analogue caerulein

1992 • 13 citations

The effect of 5-HT3 receptor antagonists on the morphine-induced excitation of A10 dopamine cells: electrophysiological studies

1994 • 13 citations

Involvement of 5-HT3 receptor in the pressure-induced increase in striatal and accumbens dopamine release and the occurrence of behavioral disorders in free-moving rats

1995 • 13 citations

The effect of 5-HT3 receptor antagonists on the writhing response in mice

1995 • 12 citations

Serotonin3 antagonists block aversion to saccharin in an amino acid-imbalanced diet

1995 • 12 citations

The effects of tacrine and zacopride on the performance of adult rats in the working memory task

1993 • 12 citations

Effects of the 5-HT3 antagonist ondansetron on benzodiazepine-induced operant behavioural dependence in rats

1992 • 12 citations

Preclinical evidence for the anxiolytic activity of 5‐HT₃ receptor antagonists: A review

1992 • 10 citations

The selective 5-HT3 receptor antagonist, ondansetron, augments the anorectic effect of d-amphetamine in nondeprived rats

1993 • 10 citations

Effects of d-fenfluramine, MK-212, and ondansetron on saline drinking in two-choice tests in the rehydrating rat

1993 • 9 citations

Evaluation of the 5HT3 antagonist ondansetron (O) for cocaine (C)-like activity and abuse potential.

1990 • 9 citations

Effects of 5HT3 Receptor Antagonism by Tropisetron on the Sleep EEG and on Nocturnal Hormone Secretion

1994 • 8 citations

Effects of BMY 33462, a selective and potent serotonin type‐3 receptor antagonist, on mesolimbic dopamine‐mediated behavior

1993 • 8 citations

5-HT receptor sub-types: Aspects of their regulation and function

1994 • 7 citations

Evaluation of Anxiolytic Action of Ondansetron in Rats during Withdrawal from Chronic Chlordiazepoxide

1992 • 7 citations

[Central serotonin receptors. Principal fundamental and functional aspects. Therapeutic applications].

1994 • 7 citations

DIFFERENTIAL EFFECTS OF ANTIPSYCHOTICS AND THE 5-HT3 ANTAGONIST ONDANSETRON ON ELECTRICAL SELF-STIMULATION OF THE VTA IN RATS.

1992 • 3 citations