Intrathecal 5-methoxy-N, N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors

A METHOD FOR DETERMINING LOSS OF PAIN SENSATION

1941 • 3,174 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors

1985 • 1,855 citations

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

1987 • 866 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors

1985 • 803 citations

Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing

1985 • 586 citations

A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system.

1988 • 435 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

Direct evidence for an interaction of β-adrenergic blockers with the 5-HT receptor

1977 • 275 citations

Neuropharmacology of Serotonin

1989 • 268 citations

Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA

1991 • 259 citations

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

1989 • 258 citations

5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord

1989 • 184 citations

Spiperone: A ligand of choice for neuroleptic receptors

1978 • 178 citations

Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord

1983 • 142 citations

Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat

1985 • 139 citations

Are there selective ligands for 5-HT1A and 5-HT1B receptor binding sites in brain?

1986 • 136 citations

Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats.

1988 • 132 citations

5-HT3 receptors modulate spinal nociceptive reflexes

1990 • 132 citations

β-Adrenoceptor blocking agents recognize a subpopulation of serotonin receptors in brain

1985 • 115 citations

Evidence that spinal 5-HT1, 5-HT2 and 5-HT3 receptor subtypes modulate responses to noxious colorectal distension in the rat

1991 • 111 citations

Noradrenergic-serotonergic interactions and nociception in the rat

1986 • 100 citations

Spinal serotonin (5-HT) receptor subtypes and nociception.

1983 • 99 citations

Heterogenous effects of serotonin in the dorsal horn of rat: the involvement of 5-HT1 receptor subtypes

1988 • 97 citations

Intrathecal serotonin in mice: Analgesia and inhibition of a spinal action of substance P

1983 • 90 citations

Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds

1988 • 81 citations

Two populations of spinothalamic tract neurons with opposite responses to 5-hydroxytryptamine

1979 • 79 citations

Effects of 5-HT receptor agonists and antagonists on a reflex response to radiant heat in normal and spinally transected rats

1982 • 78 citations

The (S)-isomer of [3H]zacopride labels 5-HT3 receptors with high affinity in rat brain

1990 • 73 citations

The role of spinal cord 5-HT1A and 5-HT1B receptors in the modulation of a spinal nociceptive reflex

1990 • 70 citations

Common pharmacological and physico-chemical properties of 5-HT3 binding sites in the rat cerebral cortex and NG 108-15 clonal cells

1990 • 67 citations

Effect of spinal norepinephrine depletion on descending inhibition of the tail flick reflex from the locus coeruleus and lateral reticular nucleus in the rat

1987 • 67 citations

Effects of the putative 5-HT1A receptor agonist 8-OH-2-(di-n-propylamino)tetralin on nociceptive sensitivity in mice

1986 • 64 citations

Serotonin Receptor “Families” in the Central Nervous System: An Overview^a

1990 • 64 citations

Chapter 26 Serotonin receptor subtypes and the modulation of pain transmission

1988 • 63 citations

5-HT depletion with 5,7-DHT, PCA and PCPA in mice: differential effects on the sensitivity to 5-MeODMT, 8-OH-DPAT and 5-HTP as measured by two nociceptive tests

1988 • 53 citations

Differential effects of substance P on serotonin-modulated spinal nociceptive reflexes

1987 • 45 citations

5-hydroxytryptamine (HT)1A receptors and the tail-flick response. II. High efficacy 5-HT1A agonists attenuate morphine-induced antinociception in mice in a competitive-like manner.

1991 • 39 citations

Nociception is enhanced after low doses and reduced after high doses of the serotonin receptor agonist 5-methoxy-N,N-dimethyltryptamine

1980 • 33 citations

(+)-8-OH-DPAT and 5-MeODMT induced analgesia is antagonised by noradrenaline depletion

1987 • 31 citations

Intrathecal 5-hydroxytryptamine and electrical stimulation of the nucleus raphe magnus in rats both reduce the antinociceptive potency of intrathecally administered noradrenaline

1988 • 29 citations

Nociceptive and antinociceptive action of serotonergic agonists administered intrathecally

1990 • 25 citations

Characterization of a Novel Serotonin Receptor Subtype (5‐HT_ls) in Rat CNS: Interaction with a GTP Binding Protein

1991 • 20 citations

Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine

1991 • 17 citations

5‐Methoxy‐N,N‐dimethyltryptamine‐induced analgesia is blocked by α‐adrenoceptor antagonists in rats

1986 • 16 citations

Intrathecal noradrenaline restores 5-methoxy-N,N-dimethyltryptamine induced antinociception abolished by intrathecal 6-hydroxydopamine

1988 • 7 citations