Spinal supersensitivity to 5-HT1, 5-HT2 and 5-HT3 receptor agonists following 5,7-dihydroxytryptamine

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors

1985 • 1,855 citations

Peripheral and spinal mechanisms of nociception.

1987 • 1,025 citations

Functional Correlates of Serotonin 5-HT₁Recognition Sites

1988 • 564 citations

The concept of selectivity in 5-HT receptor research

1990 • 425 citations

Characteristics of central 5-HT receptors and their adaptive changes following intracerebral 5,7-dihydroxytryptamine administration in the rat.

1978 • 336 citations

Chemical Neurotoxins as Denervation Tools in Neurobiology

1980 • 318 citations

Spinal 5-HT3 receptor-mediated antinociception: possible release of GABA

1991 • 259 citations

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

1989 • 258 citations

Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord

1991 • 207 citations

Autoradiographic localization of 5-hydroxytryptamine1A, 5-hydroxytryptamine1B and 5-hydroxytryptamine1C/2 binding sites in the rat spinal cord

1993 • 185 citations

5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord

1989 • 184 citations

5-HT3 receptors in the rat central nervous system are mainly located on nerve fibres and terminals

1993 • 162 citations

Biochemical and pharmacological characterization of CGS 12066B, a selective serotonin-1B agonist

1987 • 159 citations

Effects of 5, 7-dihydroxytryptamine on serotonin1 and serotonin2 receptors throughout the rat central nervous system using quantitative autoradiography

1987 • 155 citations

Serotonergic innervation of the dorsal horn of rat spinal cord: light and electron microscopic immunocytochemical study

1991 • 146 citations

Pharmacological antagonism of the antinociceptive effects of serotonin in the rat spinal cord

1983 • 142 citations

Subtypes of the 5-HT receptor mediating the behavioural responses to 5-methoxy-N,N-dimethyltryptamine in the rat

1985 • 139 citations

5-HT3 receptors modulate spinal nociceptive reflexes

1990 • 132 citations

Mechanisms of effects of intrathecal serotonin on nociception and blood pressure in rats.

1988 • 132 citations

Serotonin and pain

1991 • 118 citations

Fine structure of serotonin-containing axons in the marginal zone of the rat spinal cord

1983 • 116 citations

Ion conductances affected by 5-HT receptor subtypes in mammalian neurons

1990 • 115 citations

Evidence that spinal 5-HT1, 5-HT2 and 5-HT3 receptor subtypes modulate responses to noxious colorectal distension in the rat

1991 • 111 citations

Changes in sensitivity to intrathecal norepinephrine and serotonin after 6-hydroxydopamine (6-OHDA), 5,6-dihydroxytryptamine (5,6-DHT) or repeated monoamine administration.

1982 • 108 citations

Intracerebroventricular administration of 5,7-dihydroxytryptamine to mice increases both head-twitch response and the number of cortical 5-HT2 receptors

1985 • 107 citations

Differential roles of 5-hydroxytryptamine1A and 5-hydroxytryptamine1B receptor subtypes in modulating spinal nociceptive transmission in mice.

1993 • 101 citations

Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord

1991 • 96 citations

Effects of 5-HT receptor agonists and antagonists on a reflex response to radiant heat in normal and spinally transected rats

1982 • 78 citations

Identification of 5-HT3 binding sites in rat spinal cord synaptosomal membranes

1988 • 69 citations

Morphology of Central Serotonin Neurons

1990 • 67 citations

Time course of changes in nociception after 5,6-dihydroxytryptamine lesions of descending 5-HT pathways

1983 • 67 citations

Depletion of brain serotonin differently affects behaviors induced by 5HT1A, 5HT1C, and 5HT2 receptor activation in rats

1991 • 65 citations

Evidence that RU 24969‐induced locomotor activity in C57/B1/6 mice is specifically mediated by the 5‐HT_1B receptor

1993 • 61 citations

Identification of 5-hydroxytryptamine1 binding site subtypes in rat spinal cord

1987 • 53 citations

Selective serotonin1A/1B agonists differentially affect spinal nociceptive reflexes

1990 • 53 citations

5-HT depletion with 5,7-DHT, PCA and PCPA in mice: differential effects on the sensitivity to 5-MeODMT, 8-OH-DPAT and 5-HTP as measured by two nociceptive tests

1988 • 53 citations

Intravenous administration of the serotonin agonist m-chlorophenylpiperazine (mCPP) increases extracellular serotonin in the diencephalon of awake rats

1993 • 51 citations

Paradoxical increase of 5-hydroxytryptamine2 receptors and 5-hydroxytryptamine2 receptor mRNA in cerebellar granule cells after persistent 5-hydroxytryptamine2 receptor stimulation.

1993 • 47 citations

Increase of central 5-HT1B binding sites following 5,7-dihydroxytryptamine axotomy in the adult rat

1993 • 46 citations

Evidence for hyperdensity of 5HT1B binding sites in the substantia nigra of the rat after 5,7-dihydroxytryptamine intraventricular injection

1986 • 41 citations

The 5-HT transporter is an additional site of action for the 5-HT agonists RU 24969 and TFMPP

1991 • 41 citations

Changes in nociception after intrathecal administration of 5,6-dihydroxytryptamine in mice

1983 • 39 citations

Alterations in serotonin binding sites after 5,7-dihydroxytryptamine treatment in the rat spinal cord

1989 • 32 citations

Characterization of 5-hydroxytryptamine1B receptors in rat spinal cord via [125I]iodocyanopindolol binding and inhibition of [3H]-5-hydroxytryptamine release.

1992 • 30 citations

Noradrenergic mediation of spinal antinociception by 5-hydroxytryptamine: characterization of receptor subtypes

1992 • 29 citations

Effect of 5,7-dihydroxytryptamine lesion on mianserin-induced conditioned place aversion and on 5-hydroxytryptamine1C receptors in the rat brain

1993 • 26 citations

Selective Neurotoxic Lesions of Descending Serotonergic and Noradrenergic Pathways in the Rat

1985 • 25 citations

The induction of serotonin3-like receptor supersensitivity and dopamine receptor subsensitivity in the rat medial prefrontal cortex after the intraventricular administration of the neurotoxin 5,7-dihydroxytryptamine: A microiontophoretic study

1994 • 25 citations

Identification of a novel 5-HT1 binding site in rat spinal cord

1990 • 20 citations

Characterization of a Novel Serotonin Receptor Subtype (5‐HT_ls) in Rat CNS: Interaction with a GTP Binding Protein

1991 • 20 citations

A pharmacological analysis of the rat spinal cord serotonin (5-HT) autoreceptor

1988 • 19 citations

Regional central serotonin-2 receptor binding and phosphoinositide turnover in rats with 5,7-dihydroxytryptamine lesions

1990 • 19 citations

Supersensitivity to intrathecal 5-hydroxytryptamine, but not noradrenaline, following depletion of spinal 5-hydroxytryptamine by 5,7-dihydroxytryptamine administered into various sites

1990 • 18 citations

Noradrenergic and purinergic involvement in spinal antinociception by 5-hydroxytryptamine and 2-methyl-5-hydroxytryptamine

1991 • 17 citations

Neonatal 5,7-DHT lesions upregulate [3H]mesulergine-labelled spinal 5-HT1C binding sites in the rat

1990 • 16 citations

Intrathecal 5-methoxy-N, N-dimethyltryptamine in mice modulates 5-HT1 and 5-HT3 receptors

1993 • 15 citations

The effect of intracerebroventricular 5,7-dihydroxytryptamine on morphine analgesia is time-dependent

1986 • 13 citations

Role of ascending and descending serotonergic pathways in the antinociceptive effect of baclofen

1988 • 12 citations

Opioid and Nonopioid Antinociception as Revealed by Lesion Studies

1991 • 2 citations