Preclinical evidence for the anxiolytic activity of 5‐HT₃ receptor antagonists: A review

Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines

1980 • 1,340 citations

Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine

1986 • 1,255 citations

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

1984 • 951 citations

Identification and distribution of 5-HT3 receptors in rat brain using radioligand binding

1987 • 866 citations

Identification of serotonin M-receptor subtypes and their specific blockade by a new class of drugs

1985 • 845 citations

Ethologically-based animal models of anxiety disorders

1990 • 841 citations

TWO KINDS OF TRYPTAMINE RECEPTOR

1957 • 838 citations

A simple and reliable conflict procedure for testing anti-anxiety agents

1971 • 832 citations

The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs

1980 • 813 citations

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat

1960 • 785 citations

5-HT3 receptors are membrane ion channels

1989 • 630 citations

Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines

1981 • 509 citations

Animal models for the study of anti-anxiety agents: A review

1985 • 457 citations

MDL 72222: a potent and highly selective antagonist at neuronal 5-hydroxytryptamine receptors

1984 • 437 citations

The comparative efficacy of buspirone and diazepam in the treatment of anxiety

1979 • 426 citations

Conditioned defensive burying: A new paradigm for the study of anxiolytic agents

1981 • 425 citations

Efficacy of Ondansetron (Gr 38032F) and the Role of Serotonin in Cisplatin-Induced Nausea and Vomiting

1990 • 417 citations

Comparison of the 5-Hydroxytryptamine₃(Serotonin) Antagonist Ondansetron (Gr 38032F) with High-Dose Metoclopramide in the Control of Cisplatin-Induced Emesis

1990 • 409 citations

Pharmacological properties of GR38032F, a novel antagonist at 5‐HT₃ receptors

1988 • 378 citations

Burying as a defensive response in rats.

1978 • 358 citations

Effects of the 5‐HT₃ receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain

1987 • 354 citations

Burying as a defensive response in rats

1978 • 353 citations

The potential anxiolytic activity of GR38032F, a 5‐HT₃‐receptor antagonist

1988 • 332 citations

Buspirone

1986 • 330 citations

Pharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigm.

1986 • 309 citations

Major tranquillizers can be distinguished from minor tranquillizers on the basis of effects on marble burying and swim-induced grooming in mice

1986 • 287 citations

Functional aspects of ultrasound production by infant albino rats (Rattus norvegicus)

1972 • 284 citations

Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release

1989 • 277 citations

Neuropharmacology of Serotonin

1989 • 268 citations

Diazepam and flurazepam: Effects on conditioned fear as measured with the potentiated startle paradigm

1979 • 267 citations

Noradrenergic agonists and antagonists: Effects on conditioned fear as measured by the potentiated startle paradigm

1979 • 263 citations

Pharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigm.

1986 • 261 citations

Neuropharmacology of Serotonin

1986 • 251 citations

Release of endogenous dopamine by stimulation of 5-hydroxytryptamine3 receptors in rat striatum.

1989 • 238 citations

Serotonin receptor subtypes : basic and clinical aspects

1991 • 217 citations

5‐HT₃ receptors

1990 • 205 citations

Behavioural Pharmacology of 5-HT

1990 • 203 citations

Pharmacological characterization of 5-hydroxytryptamine4(5-HT4) receptors positively coupled to adenylate cyclase in adult guinea pig hippocampal membranes: effect of substituted benzamide derivatives.

1990 • 196 citations

5-Ht1a Agonists, 5-Ht3 Antagonists and Benzodiazepines: Their Comparative Behavioural Pharmacology

1991 • 194 citations

An evaluation of the elevated plus-maze test using the novel anxiolytic buspirone

1989 • 192 citations

A test of anxiety that distinguishes between the actions of benzodiazepines and those of other minor tranquilisers and of stimulants

1979 • 191 citations

The effects of ondansetron, a 5-HT3 receptor antagonist, on cognition in rodents and primates

1990 • 190 citations

5-hydroxytryptamine m-receptor antagonism to prevent cisplatin-induced emesis

1986 • 190 citations

Effects of 5‐HT uptake inhibitors, agonists and antagonists on the burying of harmless objects by mice; a putative test for anxiolytic agents

1991 • 179 citations

Benzodiazepines as appetite-enhancing compounds

1980 • 178 citations

5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward

1989 • 176 citations

Animal Models in Psychopharmacology

1991 • 175 citations

Zacopride: anxiolytic profile in rodent and primate models of anxiety

1988 • 170 citations

8-OH-DPAT-induced hyperphagia: Its neural basis and possible therapeutic relevance

1986 • 167 citations

5-Hydroxytryptamine3 receptors in the human brain: Autoradiographic visualization using [3H]ICS 205-930

1989 • 158 citations

Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors

1987 • 157 citations

Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat

1987 • 156 citations

A model to measure anticipatory anxiety in mice?

1989 • 152 citations

Identification of serotonin 5-HT3 recognition sites in membranes of N1E-115 neuroblastoma cells by radioligand binding.

1988 • 149 citations

Blockade of neuronal tryptamine receptors by metoclopramide

1978 • 148 citations

Animal Models for Predicting Clinical Efficacy of Anxiolytic Drugs: Social Behaviour

1985 • 142 citations

Neuropharmacological and physiological validation of a computer-controlled two-compartment black and white box for the assessment of anxiety

1989 • 136 citations

Animal Models for Anxiety and Response to Serotonergic Drugs

1989 • 135 citations

The distribution of specific binding of the 5-HT3 receptor ligand [3H]GR65630 in rat brain using quantitative autoradiography

1988 • 129 citations

Characterisation and autoradiographic localisation of 5-HT3 receptor recognition sites identified with [3H]-(S)-zacopride in the forebrain of the rat

1990 • 128 citations

NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations

1991 • 127 citations

Antiemetic properties of the 5HT3-receptor antagonist, gr38032f

1987 • 123 citations

Pharmacological validation of a novel animal model of anticipatory anxiety in mice

1990 • 120 citations

Effect of 5‐HT₃ receptor antagonists on responses to selective activation of mesolimbic dopaminergic pathways in the rat

1990 • 109 citations

Lack of effects of 5HT3 receptor antagonists in the social interaction and elevated plus-maze tests of anxiety in the rat

1989 • 109 citations

Ondansetron inhibits a behavioural consequence of withdrawing from drugs of abuse

1990 • 108 citations

Characterization of nitric oxide synthases in non‐adrenergic non‐cholinergic nerve containing tissue from the rat anococcygeus muscle

1991 • 107 citations

Blockade of the discriminative stimulus effects of ethanol with 5-HT3 receptor antagonists

1991 • 103 citations

Blockade of serotonin receptors on autonomic neurones by (−)-cocaine and some related compounds

1979 • 103 citations

The infant rat separation paradigm: a novel test for novel anxiolytics

1991 • 103 citations

Behavioral studies with anxiolytic drugs. VI. Effects on punished responding of drugs interacting with serotonin receptor subtypes.

1989 • 99 citations

5-HT3 receptor antagonists block morphine- and nicotine-induced place-preference conditioning

1988 • 98 citations

Sites of action of ondansetron to inhibit withdrawal from drugs of abuse

1990 • 96 citations

Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone

1988 • 95 citations

Effects of anxiolytic and anxiogenic drugs on exploratory activity in a simple model of anxiety in mice

1989 • 94 citations

Anxiolytic effects of buspirone and gepirone in the fear-potentiated startle paradigm

1988 • 93 citations

Identification and Characterisation of 5‐Hydroxytryptamine₃ Recognition Sites in Human Brain Tissue

1989 • 92 citations

Core temperature: Some shortcomings of rectal temperature measurements

1977 • 88 citations

Evidence that the amygdala is involved in the disinhibitory effects of 5-HT3 receptor antagonists

1991 • 84 citations

Benzodiazepine ligands, nociception and ?defeat? analgesia in male mice

1987 • 82 citations

Behavioral studies with anxiolytic drugs. III. Antipunishment actions of buspirone in the pigeon do not involve benzodiazepine receptor mechanisms.

1986 • 81 citations

Evidence that central 5‐hydroxytryptaminergic neurones are involved in the anxiolytic activity of buspirone

1989 • 79 citations

One-trial learning in the domestic rat.

1950 • 78 citations

Modulation of the brain aversive system by gabaregic and serotonergic mechanisms

1986 • 76 citations

Effects of serotonin receptor antagonists on PAG stimulation induced aversion: different contributions of 5HT1, 5HT2 and 5HT3 receptors

1989 • 74 citations

Indazoles as indole bioisosteres: synthesis and evaluation of the tropanyl ester and amide of indazole-3-carboxylate as antagonists at the serotonin 5HT3 receptor

1987 • 73 citations

The (S)-isomer of [3H]zacopride labels 5-HT3 receptors with high affinity in rat brain

1990 • 73 citations

Enhancing GABAergic transmission reverses the aversive state in rats induced by electrical stimulation of the periaqueductal grey region

1982 • 69 citations

Acute non-opioid analgesia in defeated male mice

1986 • 69 citations

Actions of Buspirone in a Putative Model of Anxiety in the Mouse

1988 • 68 citations

Characterization of [³H]Quipazine Binding to 5‐Hydroxytryptamine₃ Receptors in Rat Brain Membranes

1989 • 68 citations

Modulation of baseline behavior in rats by putative serotonergic agents in three ethoexperimental paradigms

1990 • 67 citations

Characterization of the Discriminative Stimulus Properties Induced by 5‐HT₁ and 5‐HT₂ Agonists in Rats

1989 • 61 citations

The anti-aversive action of minor tranquillizers

1984 • 60 citations

Resident's scent: A critical factor in acute analgesic reaction to defeat experience in male mice

1986 • 59 citations

The effects of compounds acting at the benzodiazepine receptor complex on the ultrasonic calling of mouse pups.

1991 • 59 citations

The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepam

1989 • 59 citations

MDL72222, a serotonin 5-HT3 receptor antagonist, blocks MDMA's ability to establish a conditioned place preference

1991 • 58 citations

Effects of agents which interact with central benzodiazepine binding sites on stress-induced ultrasounds in rat pups

1987 • 56 citations

Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice

1990 • 56 citations

The differential activities of R(+)- and S(−)-zacopride as 5-HT3 receptor antagonists

1990 • 55 citations

Serotonin 5-HT3 antagonists do not alter the discriminative stimulus properties of cocaine

1991 • 55 citations

Opposite control mediated by central 5-HT1A and non-5-HT1A (5-HT1B or 5-HT1C) receptors on periaqueductal gray aversion

1989 • 54 citations

5-HT1C receptors in the serotonergic control of periaqueductal gray induced aversion in rats

1990 • 53 citations

Prevention of the analgesic consequences of social defeat in male mice by 5-HT1A anxiolytics, buspirone, gepirone and ipsapirone

1989 • 51 citations

Cadaverine and putrescine initiate the burial of dead conspecifics by rats

1981 • 51 citations

Effects of the 5-HT3 antagonist GR38032F (ondansetron) on benzodiazepine withdrawal in rats

1990 • 51 citations

8-OH-DPAT-induced place preference and place aversion: effects of PCPA and dopamine antagonists

1991 • 49 citations

Current and future trends in anticonvulsant, anxiety and stroke therapy

1989 • 49 citations

Evidence that the unilateral activation of 5‐HT_1D receptors in the substantia nigra of the guinea‐pig elicits contralateral rotation

1991 • 47 citations

Modulation of the brain aversive system by GABAergic and serotonergic mechanisms

1986 • 47 citations

Behavioural studies on WAY100289, a novel 5-HT3 receptor antagonist, in two animal models of anxiety

1992 • 45 citations

Learned anticipatory rise in body temperature due to handling

1986 • 44 citations

Preclinical anxiolytic versus antipsychotic profiles of the 5‐HT₃ antagonists ondansetron, zacopride, 3α‐tropanyl‐1H‐indole‐3‐carboxylic acid ester, and 1αH, 3α, 5αH‐tropan‐3‐yl‐3,5‐dichlorobenzoate

1991 • 44 citations

Blockade of acquisition of drug-conditioned place aversion by 5HT3 antagonists

1990 • 44 citations

5-HT3 RECEPTOR ANTAGONISTS

1989 • 41 citations

Animal Behavior Models in the Analysis and Understanding of Anxiolytic Drugs Acting at Serotonin Receptors

1991 • 39 citations

The ontogeny of defensive reactions in the rat: Influence of the monoamine transmission systems

1982 • 38 citations

Are the analgesic effects of social defeat mediated by benzodiazepine receptors?

1987 • 37 citations

Antagonism of [3H]zacopride binding to 5-HT3 recognition sites by its (R) and (S) enantiomers

1990 • 36 citations

Stimulus control of defensive burying in the rat

1980 • 36 citations

5‐HT₃ Receptors

1990 • 34 citations

8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition

1990 • 32 citations

Highly potent inhibitory effects of 5-HT3 receptor antagonist, GR38032F, on non-opioid defeat analgesia in male mice

1990 • 30 citations

GABA-B receptor activation and conflict behaviour

1988 • 29 citations

Effects of 8-OH-DPAT, buspirone and ICS 205-930 on feeding in a novel environment: comparisons with chlordiazepoxide and FG 7142

1990 • 29 citations

Behavioural and neuropharmacological aspects of maternal aggression in rodents

1990 • 29 citations

An ethological study of the effects of buspirone and the 5-HT3 receptor antagonist, BRL 43694 (granisetron) on behaviour during social interactions in female and male mice

1991 • 28 citations

Topographical distribution of 5-HT3 receptor recognition sites in the ferret brain stem

1990 • 28 citations

Anxiolytic-like activity of R(+)- and S(−)-zacopride in mice

1991 • 27 citations

Similar effects of diazepam and the 5-HT3 receptor antagonist ICS 205-930 on place aversion conditioning

1988 • 26 citations

Neuroanatomical structures involved in the action of the 5-HT3 antagonist ondansetron: A 2-deoxyglucose autoradiographic study in the rat

1991 • 26 citations

Behavioural effects in gerbils of the 5-HT3 receptor antagonists, BRL 43694 and ICS 205-930, under circumstances of high and low light intensity

1990 • 25 citations

Anxiolytic profile of GR 38032F in the potentiated startle paradigm

1989 • 24 citations

Blockade of non-opioid analgesia in intruder mice by selective neuronal and non-neuronal benzodiazepine recognition site ligands

1988 • 23 citations

Chronic administration of the 5-HT3 receptor antagonist BRL 43694; effects on reflex epilepsy and social behaviour of the Mongolian gerbil

1990 • 23 citations

5‐HT₃ receptor agonism may be responsible for the emetic effects of zacopride in the ferret

1991 • 22 citations

Blockade by nifedipine of responses to intravenous bolus injection or infusion of α₁‐and α₂‐adrenoceptor agonists in the pithed rat

1987 • 22 citations

Discriminative stimulus properties of the serotonergic compound eltoprazine.

1992 • 20 citations

Behavioural and Hormonal Indices of Anxiolytic and Anxiogenic Drug Action in the Shock Prod Defensive Burying/Avoidance Paradigm

1991 • 19 citations

A New Animal Model for Anticipatory Anxiety?

1991 • 19 citations

Further characterization of the discriminative stimulus effects of buspirone using monoamine agonists and antagonists in the pigeon

1989 • 16 citations

Defensive burying in the Mongolian gerbil (Meriones unguiculatus) as a function of size and shape of the test chamber

1982 • 16 citations

Effects of granisetron and lorazepam, alone and in combination, on psychometric performance.

1991 • 16 citations

The Electrophysiology of 5-HT

1991 • 14 citations

Drug Discrimination and Animal Models

1991 • 12 citations

Cross-species responses in the defensive burying paradigm: A comparison between Long-Evans rats (Rattus norvegicus), Richardson's ground squirrels (Spermophilus richardsonii), and thirteen-lined ground squirrels (Catellus tridecemlineatus).

1989 • 12 citations

Classification of opioid and 5-hydroxytryptamine receptors by means of discriminative drug effects

1987 • 10 citations

Cross-species responses in the defensive burying paradigm: A comparison between Long-Evans rats (Rattus norvegicus), Richardson's ground squirrels (Spermophilus richardsonii), and thirteen-lined ground squirrels (Catellus tridecemlineatus).

1989 • 9 citations

Pharmacological Models in the Development of Antipsychotic Drugs — New Strategies

1991 • 9 citations

Defensive burying of aversive fluids in rats: The possible role of odor

1984 • 8 citations

Characterization of 5-HT3-like Receptors in the Rat Cortex: Electrophysiological and Biochemical Studies

1991 • 8 citations

Effects of triazolam on heart rate level and on phasic cardiac response to noise during sleep

1988 • 7 citations

Behavioural Correlates of the Activation of 5-HT Receptors

1989 • 6 citations

Free Communications 2 Psychopharmacology of Anxiety

1989 • 5 citations

Molecular Mechanisms of Action Induced by 5-HT3 Receptors in a Neuronal Cell Line and by 5-HT2 Receptors in a Glial Cell Line

1991 • 3 citations

Extinction of Conflict Behaviour

1991 • 2 citations

Antiemetic and emetic effects of 5-HT3 antagonists in the pigeon: Relevance of serotonergic neurotransmission

1990 • 1 citations